subacute toxicity
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2022 ◽  
Hiva Alipanah ◽  
Hashmieh Kabi Doraghi ◽  
Mehran Sayadi ◽  
Amene Nematollahi ◽  
Ava Soltani Hekmat ◽  

Julia Stein ◽  
Bárbara Campos Jorge ◽  
Ana Carolina Casali Reis ◽  
Joyce Alencar Santos Radai ◽  
Suyane da Silva Moreira ◽  

2022 ◽  
Vol 11 (1) ◽  
pp. 01-09
Tuem SR ◽  
Ndomou M ◽  
Manz KJC ◽  
Nsoga JVF ◽  
Bekwankoa FGS ◽  

2022 ◽  
pp. 114919
Muhammad Qamar ◽  
Saeed Akhtar ◽  
Tariq Ismail ◽  
Muqeet Wahid ◽  
Sajed Ali ◽  

2022 ◽  
pp. 112825
Dragana Javorac ◽  
Simona Tatović ◽  
Milena Anđelković ◽  
Aleksandra Repić ◽  
Katarina Baralić ◽  

2022 ◽  
pp. 100224
Ashutosh Kumar ◽  
Brijesh Kumar ◽  
Rajesh Kumar ◽  
Ajay Kumar ◽  
Manish Singh ◽  

2021 ◽  
Vol 20 (10) ◽  
pp. 2117-2125
Chunlan Su ◽  
Xue Zhang ◽  
Peng Du ◽  
Ting Zeng ◽  
Qin Liang ◽  

Purpose: To investigate the acute and subacute toxicity of Aucklandia lappa Decne. seed oil (ALDO) in mice and rats.Methods: A single dose of 10 g ALDO/kg was administered to Kunming mice in an acute oral toxicity experiment. Their weight and feed consumption were recorded for 14 days to observe whether they had symptoms of poisoning and mortality. Sprague-Dawley (SD) rats were administered 0.89, 1.77 and 3.54 g/kg for 28 days, and symptoms of poisoning and mortality were monitored daily. Body weight, feedconsumption, hematology, serum biochemical parameters, relative organ weight, and histopathology of the experimental and control groups were compared.Results: The acute oral toxicity study revealed that there was no significant difference in the macroscopic results, including mortality, feed consumption and weight growth between the group dosed with 10 g ALDO/kg (p > 0.05) and the control group. In the subacute toxicity test, SD rats had a higher weight growth rate and feed utilization after doses of 0.89 g ALDO/kg (p < 0.01). However, compared with the control group (p > 0.05), there was also no significant difference in biochemical and hematological parameters, relative organ weight, or in macroscopic and histological features of both animal types. The electrolyte concentrations of Na and Cl increased at the doses of 1.77 and 3.54 g/kg (p < 0.01).Conclusion: These results suggest that ALDO is relatively safe when administered orally to rats and provide a theoretical basis for the development of new food resources.

2021 ◽  
Vol 11 (6) ◽  
pp. 94-100
Lane Adrien GOH BI ◽  
Noel Kouame TOTO ◽  
Ouga Stanislas ZAHOUI ◽  
Yomalan KASSI ◽  
Semi Anthelme NENE Bi ◽  

The present study is a contribution to the enhancement of Ivorian traditional medicine, by carrying out bio-tolerance tests of an aqueous extract of the aerial parts of Crotalaria retusa (EACr) in mice and rats according to the guidelines of the Organization for Economic Co-operation and Development (OECD) 423 and 407, respectively. The doses of 2000 and 5000 mg/kg of body weight (BW) of the extract were used for acute toxicity. For subacute toxicity which lasted 28 days, doses of 500, 1000, and 2000 mg/kg BW have been used. The administration of the single doses of 2000 and 5000 mg/kg BW of EACr did not provoke death in female mice in the acute toxicity setting. For subacute toxicity in rats (male and female), the administration of repetitive doses of 500, 1000, and 2000 mg/kg BW of EACr over a period of 28 days did not cause death in these animals. In females, these doses caused weight loss and a decrease in platelets. The extract reduced the activity of AST in both sexes of rats. The findings also showed that this extract would possess a nephroprotective property in male and female rats. Keywords: Crotalaria retusa, Acute and subacute toxicities, Wistar rat, Swiss mice

2021 ◽  
Vol 2 (3 2021) ◽  
pp. 1-13
Liana Kuprash ◽  
Tetyana Panteleymonova ◽  
Ludmila Sharabura ◽  
Sergiy Mykhalskiy ◽  
Pavlo Klymenko ◽  

Abstract. The aim of the work was to study toxic properties of the new combined drug which comprise nitrovasodilator molsidomine and adenosine- 5’-triphosphate in a form of coordination compound with histidine, magnesium, and potassium (ATP-LONG). The drug was examined for its acute and subacute toxicity on Balb/c mice and Wistar rats of reproductive age with peroral (p/o) and sublingual (s/l) administrations. It has been established that LD50 of the substance contains over 10000 mg/kg (p/o) and 5010 mg/kg (s/l), which corresponds to the category of Practically non-toxic substances. The repetitive administrations within a 28 day period of the conditionally therapeutic dose of 260 mg/hg (s/l) did not cause any negative impact on physiological, biochemical, histological values in male and female rats. In doses 1300 and 2080 mg/kg, which exceed conditionally therapeutic doses by 5 and 8 times, the combination was not changing clinical laboratory urine and blood values but induced histological changes such as dilation and plethora of capillaries along with edema of smooth muscle cells of the brain, myocardium, liver, spleen, kidneys, and adrenal glands in rats. Additionally, the particular dosages of the combined substance provoked irritation of the mucous membrane of the tongue. Detected effects of the drug do not carry any pathological character and can be viewed as a specific reaction of the organism to high doses of nitrovasodilator. However, the duration and reversibility of unwanted consequences of molsidomine overdose, particularly in its combined form, need further investigation. Keywords: combination of molsidomine and ATP-LONG, acute and subacute toxicity

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