Comparison of risk profiles between survivors and victims of sudden cardiac death from an acute coronary event

2009 ◽  
Vol 41 (2) ◽  
pp. 120-127 ◽  
Author(s):  
Kari S. Kaikkonen ◽  
Marja-Leena Kortelainen ◽  
Heikki V. Huikuri
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Coronary Event ◽  
Acute Coronary Event ◽  
Risk Profiles

Abstract 3667: Comparison of Risk Profiles between Survivors and Victims of Sudden Cardiac Death of an Acute Coronary Event

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Kari S Kaikkonen ◽  
Marja-Leena Kortelainen ◽  
Heikki V Huikuri
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Sudden Cardiac Death ◽  
Cardiac Hypertrophy ◽  
Odds Ratio ◽  
Cardiac Death ◽  
Coronary Event ◽  
Acute Coronary Event ◽  
Risk Profiles ◽  
History Of

Introduction. There is little information on the specific risk factors leading to sudden cardiac death (SCD) during an acute coronary event, because the risk variables may overlap with those of non-fatal coronary event. This study was designed to compare the risk profiles of SCD victims and survivors of an acute coronary event. Methods and Results. A case-control study included consecutive victims of SCD (n=425, mean age 64±11 years) verified to be due to an acute coronary event at medicolegal autopsy and consecutive patients surviving an acute myocardial infarction (AMI, n=644, mean age 62±10 years). Common cardiovascular risk factors, cardiac hypertrophy, and severity of coronary artery disease (CAD) were assessed in both groups. Family history of SCD (odds ratio 1.5, 95% CI 1.0 to 2.2, p=0.03), male gender (odds ratio 1.8, 95% CI 1.3 to 2.4, p<0.001), current smoking (odds ratio 2.0, 95% CI 1.5 to 2.6, p<0.001), cardiac hypertrophy (odds ratio 3.0, 95% CI 2.3 to 3.9, p<0.001) and 3-vessel CAD (odds ratio 5.4, 95% CI 3.6 to 8.2, p<0.001) were more common among the victims of SCD as compared to survivors of AMI. On the contrary, history of hypercholesterolemia (p<0.001) was less common among the SCD victims. There was a cumulative increase of risk of being a SCD victim vs. AMI survivor when more than one risk factor was present, the odds ratio being 44.3 (95% CI 8.0 to 246.7) in a current male smoker with a family history of SCD and cardiac hypertrophy. When 3-vessel CAD was added to the combined risk score, all subjects (7% of the SCD victims) were in the group of SCD giving a 100% sensitivity and specificity, respectively, in differentiating between the SCD victims and AMI survivors. Conclusions. There are specific features that differentiate the victims of SCD from survivors of an acute coronary event. Clustering of several variables, such as family history of SCD, smoking, cardiac hypertrophy, and 3-vessel CAD indicate a very high risk of SCD.

Antiepileptic medications and the risk for sudden cardiac death caused by an acute coronary event: a prospective case-control study

2016 ◽  
Vol 48 (1-2) ◽  
pp. 111-117 ◽  
Author(s):  
Eeva Hookana ◽  
Hanna Ansakorpi ◽  
Marja-Leena Kortelainen ◽  
M. Juhani Junttila ◽  
Kari S Kaikkonen ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Case Control Study ◽  
Coronary Event ◽  
Case Control ◽  
Acute Coronary Event ◽  
Antiepileptic Medications ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Association of Early Repolarization and Sudden Cardiac Death During an Acute Coronary Event

2012 ◽  
Vol 5 (4) ◽  
pp. 714-718 ◽  
Author(s):  
Jani T. Tikkanen ◽  
Viktor Wichmann ◽  
M. Juhani Junttila ◽  
Meri Rainio ◽  
Eeva Hookana ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Coronary Event ◽  
Acute Coronary Event ◽  
Early Repolarization

scholarly journals Family History and the Risk of Sudden Cardiac Death as a Manifestation of an Acute Coronary Event

Circulation ◽  
2006 ◽  
Vol 114 (14) ◽  
pp. 1462-1467 ◽  
Author(s):  
Kari S. Kaikkonen ◽  
Marja-Leena Kortelainen ◽  
Eeva Linna ◽  
Heikki V. Huikuri
Keyword(s):  
Family History ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Coronary Event ◽  
Acute Coronary Event

scholarly journals Psychotropic medications and the risk of sudden cardiac death during an acute coronary event

2011 ◽  
Vol 33 (6) ◽  
pp. 745-751 ◽  
Author(s):  
J. Honkola ◽  
E. Hookana ◽  
S. Malinen ◽  
K. S. Kaikkonen ◽  
M. J. Junttila ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Coronary Event ◽  
Psychotropic Medications ◽  
Acute Coronary Event

scholarly journals Low lung function, sudden cardiac death and non-fatal coronary events in the general population

2021 ◽  
Vol 8 (1) ◽  
pp. e001043
Author(s):  
Suneela Zaigham ◽  
Karl-Fredrik Eriksson ◽  
Per Wollmer ◽  
Gunnar Engström
Keyword(s):  
Sudden Cardiac Death ◽  
Lung Function ◽  
Cardiac Death ◽  
Cox Regression ◽  
Strong Predictor ◽  
Previous History ◽  
Coronary Event ◽  
Forced Expiratory Volume ◽  
P Value ◽  
Cardiac Events

BackgroundMany of those who suffer from a first acute coronary event (CE) die suddenly during the day of the event, most of them die outside hospital. Poor lung function is a strong predictor of future cardiac events; however, it is unknown whether the pattern of lung function impairment differs for the prediction of sudden cardiac death (SCD) versus non-fatal CEs. We examined measures of lung function in relation to future SCD and non-fatal CE in a population-based study.MethodsBaseline spirometry was assessed in 28 584 middle-aged subjects, without previous history of CE, from the Malmö Preventive Project. The cohort was followed prospectively for incidence of SCD (death on the day of a first CE, inside or outside hospital) or non-fatal CE (survived the first day). A modified version of the Lunn McNeil’s competing risk method for Cox regression was used to run models for both SCD and non-fatal CE simultaneously.ResultsA 1-SD reduction in forced expiratory volume in 1 s (FEV1) was more strongly associated with SCD than non-fatal CE even after full adjustment (FEV1: HR for SCD: 1.23 (1.15 to 1.31), HR for non-fatal CE 1.08 (1.04 to 1.13), p value for equal associations=0.002). Similar associations were found for forced vital capacity (FVC) but not FEV1/FVC. The results remained significant even in life-long never smokers (FEV1: HR for SCD: 1.34 (1.15 to 1.55), HR for non-fatal CE: 1.11 (1.02 to 1.21), p value for equal associations=0.038). Similar associations were seen when % predicted values of lung function measures were used.ConclusionsLow FEV1 is associated with both SCD and non-fatal CE, but consistently more strongly associated with future SCD. Measurement with spirometry in early life could aid in the risk stratification of future SCD. The results support the use of spirometry for a global assessment of cardiovascular risk.

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