scholarly journals MMP-9-mediated regulation of hypoxia-reperfusion injury-related neutrophil inflammation in an in vitro proximal tubular cell model

Renal Failure ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 900-910
Author(s):  
Yan Dong ◽  
Hong Zhao ◽  
Jiangwei Man ◽  
Shengjun Fu ◽  
Li Yang
Keyword(s):  
Reperfusion Injury ◽  
Cell Model ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Proximal Tubular

scholarly journals Ischemic postconditioning inhibits apoptosis in an in vitro proximal tubular cell model

2015 ◽  
Vol 12 (1) ◽  
pp. 99-104 ◽  
Author(s):  
XIAODONG WENG ◽  
LEI WANG ◽  
HUI CHEN ◽  
XIUHENG LIU ◽  
TAO QIU ◽  
...  
Keyword(s):  
Cell Model ◽  
Proximal Tubular Cell ◽  
Ischemic Postconditioning ◽  
Tubular Cell ◽  
Proximal Tubular

Irbesartan Inhibits Albumin-Elicited Proximal Tubular Cell Apoptosis and Injury In Vitro

2010 ◽  
Vol 17 (1) ◽  
pp. 74-77 ◽  
Author(s):  
Takanori Matsui ◽  
Sho-ichi Yamagishi ◽  
Seiji Ueda ◽  
Kei Fukami ◽  
Seiya Okuda
Keyword(s):  
Cell Apoptosis ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Proximal Tubular

Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity

2010 ◽  
Vol 88 (4) ◽  
pp. 448-455 ◽  
Author(s):  
Patrina Gunness ◽  
Katarina Aleksa ◽  
Kazuhiro Kosuge ◽  
Shinya Ito ◽  
Gideon Koren
Keyword(s):  
Cell Line ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
In Vitro Toxicity ◽  
Drug Induced ◽  
Toxicity Studies ◽  
Renal Proximal Tubular Cell ◽  
Proximal Tubular ◽  
Renal Proximal Tubular

Established cell lines are widely used as in vitro models in toxicology studies. The choice of an appropriate cell line is critical when performing studies to elucidate drug-induced toxicity in humans. The porcine renal proximal tubular cell line LLC-PK1 is routinely used to study the nephrotoxic effects of drugs in humans. However, there are significant interspecies differences in drug pharmacokinetics and pharmacodynamics. The objective of this study was to determine whether the human renal proximal tubular cell line HK-2 is an acceptable model to use when performing in vitro toxicity studies to predict effects in humans. We examined 2 nephrotoxic agents, ifosfamide (IFO) and acyclovir, that exhibit different clinical nephrotoxic patterns. HK-2 cells metabolized IFO to its nephrotoxic metabolite, chloroacetaldehyde (CAA). Acyclovir induced a concentration-dependent decrease in HK-2 cell viability, suggesting that acyclovir may induce direct insult to renal proximal tubular cells. The results support clinical pathology data in humans and suggest that HK-2 cells are a suitable model to use in in vitro toxicity studies to determine drug-induced nephrotoxicity in humans.

scholarly journals G46 Developing a Human Proximal Tubular Cell Model For Cystinuria

2013 ◽  
Vol 98 (Suppl 1) ◽  
pp. A25-A26
Author(s):  
H. Rhodes ◽  
M. Woodward ◽  
G. Welsh ◽  
R. Coward
Keyword(s):  
Cell Model ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Proximal Tubular

scholarly journals Overexpressed cyclophilin B suppresses aldosterone-induced proximal tubular cell injury both in vitro and in vivo

Oncotarget ◽  
2016 ◽  
Vol 7 (43) ◽  
pp. 69309-69320 ◽  
Author(s):  
Bin Wang ◽  
Lilu Lin ◽  
Haidong Wang ◽  
Honglei Guo ◽  
Yong Gu ◽  
...  
Keyword(s):  
Cell Injury ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Cyclophilin B ◽  
Proximal Tubular

scholarly journals Sex Differences in Renal Proximal Tubular Cell Homeostasis

2016 ◽  
Vol 27 (10) ◽  
pp. 3051-3062 ◽  
Author(s):  
Thomas Seppi ◽  
Sinikka Prajczer ◽  
Maria-Magdalena Dörler ◽  
Oliver Eiter ◽  
Daniel Hekl ◽  
...  
Keyword(s):  
Sex Differences ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Cell Homeostasis ◽  
Renal Proximal Tubular Cell ◽  
Proximal Tubular ◽  
Renal Proximal Tubular

scholarly journals Proximal Tubular Cell Alkalinization Induced by Na+-Glucose Cotransport.

1995 ◽  
Vol 45 (5) ◽  
pp. 785-799 ◽  
Author(s):  
Nobuko HAGIWARA ◽  
Takahiro KUBOTA ◽  
Manabu KUBOKAWA ◽  
Mamoru FUJIMOTO
Keyword(s):  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Proximal Tubular
Sign in / Sign up

Export Citation Format

Share Document