Health Effects of Airborne Particulate Matter: Do We Know Enough to Consider Regulating Specific Particle Types or Sources?

2007 ◽  
Vol 19 (6-7) ◽  
pp. 457-481 ◽  
Author(s):  
Thomas J. Grahame ◽  
Richard B. Schlesinger
1981 ◽  
Vol 15 (4) ◽  
pp. 431-482 ◽  
Author(s):  
James P. Lodge ◽  
Alan P. Waggonerc ◽  
Donald T. Klodt ◽  
Clark N. Crain

1983 ◽  
Vol 17 (4) ◽  
pp. 899-900 ◽  
Author(s):  
Robert K. Stevens ◽  
Thomas G. Dzubay ◽  
Charles W. Lewis ◽  
Aubrey P. Altshuller

2019 ◽  
Vol 47 (8) ◽  
pp. 954-961 ◽  
Author(s):  
Kent E. Pinkerton ◽  
Chao-Yin Chen ◽  
Savannah M. Mack ◽  
Priya Upadhyay ◽  
Ching-Wen Wu ◽  
...  

The effects of particulate matter (PM) on cardiopulmonary health have been studied extensively over the past three decades. Particulate matter is the primary criteria air pollutant most commonly associated with adverse health effects on the cardiovascular and respiratory systems. The mechanisms by which PM exerts its effects are thought to be due to a variety of factors which may include, but are not limited to, concentration, duration of exposure, and age of exposed persons. Adverse effects of PM are strongly driven by their physicochemical properties, sites of deposition, and interactions with cells of the respiratory and cardiovascular systems. The direct translocation of particles, as well as neural and local inflammatory events, are primary drivers for the observed cardiopulmonary health effects. In this review, toxicological studies in animals, and clinical and epidemiological studies in humans are examined to demonstrate the importance of using all three approaches to better define potential mechanisms driving health outcomes upon exposure to airborne PM of diverse physicochemical compositions.


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