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The Breast ◽  
2022 ◽  
Vol 61 ◽  
pp. 22-28
Author(s):  
Marianne J. Heins ◽  
Kelly M. de Ligt ◽  
Janneke Verloop ◽  
Sabine Siesling ◽  
Joke C. Korevaar ◽  
...  

2022 ◽  
Vol 44 (1) ◽  
Author(s):  
Wan-Qi Chen ◽  
Xin-Yu Zhang

Abstract1,3-Butadiene (BD) is a petrochemical manufactured in high volumes. It is a human carcinogen and can induce lymphohematopoietic cancers, particularly leukemia, in occupationally-exposed workers. BD is an air pollutant with the major environmental sources being automobile exhaust and tobacco smoke. It is one of the major constituents and is considered the most carcinogenic compound in cigarette smoke. The BD concentrations in urban areas usually vary between 0.01 and 3.3 μg/m3 but can be significantly higher in some microenvironments. For BD exposure of the general population, microenvironments, particularly indoor microenvironments, are the primary determinant and environmental tobacco smoke is the main contributor. BD has high cancer risk and has been ranked the second or the third in the environmental pollutants monitored in most urban areas, with the cancer risks exceeding 10-5. Mutagenicity/carcinogenicity of BD is mediated by its genotoxic metabolites but the specific metabolite(s) responsible for the effects in humans have not been determined. BD can be bioactivated to yield three mutagenic epoxide metabolites by cytochrome P450 enzymes, or potentially be biotransformed into a mutagenic chlorohydrin by myeloperoxidase, a peroxidase almost specifically present in neutrophils and monocytes. Several urinary BD biomarkers have been developed, among which N-acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine is the most sensitive and is suitable for biomonitoring BD exposure in the general population. Exposure to BD has been associated with leukemia, cardiovascular disease, and possibly reproductive effects, and may be associated with several cancers, autism, and asthma in children. Collectively, BD is a ubiquitous pollutant that has been associated with a range of adverse health effects and diseases with children being a subpopulation with potentially greater susceptibility. Its adverse effects on human health may have been underestimated and more studies are needed.


2022 ◽  
Author(s):  
Cary A. Presant ◽  
Jonjon Macalintal ◽  
Kimlin Tam Ashing ◽  
Sophia Yeung ◽  
Brian Tiep ◽  
...  

Tobacco smoke is a well-known carcinogen associated with multiple malignancies. Patients with cancer, as well as survivors, who continue to smoke are at a greater risk for poor cancer treatment outcomes. With the emergence of the COVID-19 pandemic, there is increased frequency and severity of the infection in patients with cancer. Furthermore, smoking and/or vaping increases incidence or likelihood of progression of COVID-19. Cigarette smoking, cancer, and COVID-19 each impose disproportionate burden of illness and death among racial and ethnic minorities. Geographic and population-specific analyses reveal that neighborhoods with lower income and higher minority populations have more tobacco/vape shops and face increased risk associated with tobacco marketing. Referral to tobacco cessation has been reduced during the pandemic. To reduce the adverse health effects of tobacco dependence among patients with cancer during the pandemic, urgent evidence-based solutions are described for health systems and professionals to prioritize tobacco cessation for patients with cancer in the midst of the COVID-19 pandemic, on the basis of cessation implementation at City of Hope Medical Center.


Water ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 121
Author(s):  
Raymond S. Malikula ◽  
Chikumbusko C. Kaonga ◽  
Harold W. T. Mapoma ◽  
Fabiano G. D. Thulu ◽  
Petra Chiipa

Heavy metals may cause acute and chronic toxic effects to humans and other organisms, hence the need to treat wastewater properly, as it contains these toxicants. This work aimed at assessing zinc, copper, cadmium, and chromium in water, soil, and plants that are irrigated with effluent from Manase and Soche Wastewater Treatment Plants (WWTPs) in Blantyre, Malawi. Atomic Absorption Spectrophotometry (AAS) was used to assess the heavy metals. Heavy Metal Health Risk Assessment (HMHRA) on plants (vegetables) around both WWTPs was also conducted. Average daily dose (ADD) and target hazard quotients (THQ) were used to assess HMHRA. Physicochemical parameters were determined using standard methods from American Public Health Association (APHA). The heavy metal ranges were below detection limit (BDL) to 6.94 mg/L in water, 0.0003 to 4.48 mg/kg in soil, and 3 to 32 mg/L in plants. The results revealed that plants irrigated with effluent from WWTP had high values of aforementioned metals exceeding the Malawi Standards and WHO permissible limits. Furthermore, the health risk assessment values showed that vegetables consumed for a long period of time from Manase WWTP were likely to cause adverse health effects as compared to those from Soche WWTP.


2022 ◽  
Vol 8 ◽  
Author(s):  
Martin Grootveld

In this manuscript, a series of research reports focused on dietary lipid oxidation products (LOPs), their toxicities and adverse health effects are critically reviewed in order to present a challenge to the mindset supporting, or strongly supporting, the notion that polyunsaturated fatty acid-laden frying oils are “safe” to use for high-temperature frying practises. The generation, physiological fates, and toxicities of less commonly known or documented LOPs, such as epoxy-fatty acids, are also considered. Primarily, an introduction to the sequential autocatalytic peroxidative degradation of unsaturated fatty acids (UFAs) occurring during frying episodes is described, as are the potential adverse health effects posed by the dietary consumption of aldehydic and other LOP toxins formed. In continuance, statistics on the dietary consumption of fried foods by humans are reviewed, with a special consideration of French fries. Subsequently, estimates of human dietary aldehyde intake are critically explored, which unfortunately are limited to acrolein and other lower homologues such as acetaldehyde and formaldehyde. However, a full update on estimates of quantities derived from fried food sources is provided here. Further items reviewed include the biochemical reactivities, metabolism and volatilities of aldehydic LOPs (the latter of which is of critical importance regarding the adverse health effects mediated by the inhalation of cooking/frying oil fumes); their toxicological actions, including sections focussed on governmental health authority tolerable daily intakes, delivery methods and routes employed for assessing such effects in animal model systems, along with problems encountered with the Cramer classification of such toxins. The mutagenicities, genotoxicities, and carcinogenic potential of aldehydes are then reviewed in some detail, and following this the physiological concentrations of aldehydes and their likely dietary sources are considered. Finally, conclusions from this study are drawn, with special reference to requirements for (1) the establishment of tolerable daily intake (TDI) values for a much wider range of aldehydic LOPs, and (2) the performance of future nutritional and epidemiological trials to explore associations between their dietary intake and the incidence and severity of non-communicable chronic diseases (NCDs).


Author(s):  
Andrea Soltysova ◽  
Patricia Begerova ◽  
Kristina Jakic ◽  
Katarina Kozics ◽  
Monika Sramkova ◽  
...  

AbstractThe unique physicochemical properties make inorganic nanoparticles (INPs) an exciting tool in diagnosis and disease management. However, as INPs are relatively difficult to fully degrade and excrete, their unintended accumulation in the tissue might result in adverse health effects. Herein, we provide a methylome–transcriptome framework for chronic effects of INPs, commonly used in biomedical applications, in human kidney TH-1 cells. Renal clearance is one of the most important routes of nanoparticle excretion; therefore, a detailed evaluation of nanoparticle-mediated nephrotoxicity is an important task. Integrated analysis of methylome and transcriptome changes induced by INPs (PEG-AuNPs, Fe3O4NPs, SiO2NPs, and TiO2NPs) revealed significantly deregulated genes with functional classification in immune response, DNA damage, and cancer-related pathways. Although most deregulated genes were unique to individual INPs, a relatively high proportion of them encoded the transcription factors. Interestingly, FOS hypermethylation inversely correlating with gene expression was associated with all INPs exposures. Our study emphasizes the need for a more comprehensive investigation of INPs’ biological safety, especially after chronic exposure. Graphical abstract


2022 ◽  
Vol 131 ◽  
pp. 01006
Author(s):  
Linda Matisane ◽  
Linda Paegle ◽  
Ivars Vanadzins ◽  
Asnate Anna Linde

Workplace risk assessment is one of the key tools for improving occupational safety and health conditions. However, providing risk assessment for teleworkplaces in the COVID-19 pandemic-related restrictions has been a challenge for employers. The objective of this study was to identify the frequency of implementation of workplace risk assessment for teleworkplaces and the association between it and self-reported health complaints among teleworkers during the 1st emergency state of the COVID-19 pandemic in Latvia. Teleworkers were recruited using a non-probability sampling (snowball sampling) method and social media advertisements. To obtain data that is representative of the demographic profile of the working population in Latvia, the sample was weighed based on gender and age. Out of 447 teleworking respondents included in our analysis, only 20.3% have mentioned that their employer had assessed the teleworking conditions (additional 8.1% reported partial assessment). Workers who have reported lack of risk assessment more often have health related complaints – e.g., pain longer than three days (26.9% with risk assessment versus 73.1% with no risk assessment), sore eyes (24.4% versus 75.6%) and anxiety (21.8% versus 78.2%) (p < 0.001 in all cases, except for pain). Increased incidence of occupational musculoskeletal diseases and burnout can be predicted in coming years in Latvia. Good practise examples should be gathered and promoted; guidelines for labour inspection should be developed in order to cover supervision of teleworking workplaces.


2021 ◽  
Vol 21 (8) ◽  
pp. 524-530
Author(s):  
Linda Palavi ◽  
Vili Nosa

ABSTRACT Introduction Tongan female smokers’ smoking experiences have manifested within a realm of socioeconomic and cultural conditions in New Zealand with cessation service engagement relatively low. Due to the projected tobacco burden attributed to Pacific women, pertinent research proves vital to bettering understandings of smoking and cessation within this group. This study explored the knowledge and experiences of smoking and smoking cessation services among Tongan women aged 16 years and over, living in the Auckland region. Methods This qualitative research design utilised the Kakala model to ensure processes were culturally appropriate and meaningful. Data was collected through eight face-to-face semi-structured interviews transcribed by the researcher and employed the toli, teu and luva process from the Kakala model to form relevant themes. Findings The findings suggest smoking among Tongan females is a social vector that marks independence and maintains friendships, despite known adverse health effects and stigma. It is characterised as stress relief that has habituated into day-to-day routine for most. Their aspirations to live longer for their family is a strong motivator but quitting remains difficult and should be done autonomously by the individual. Tongan female smokers stated smoking cessation services as ineffective and need to be adapted and consulted by and within the community. Stop smoking services should encourage autonomy among Tonga women in order to improve utilisation and engagement. Service delivery for Tongan female smokers needs to be on-going and long-term support reoriented within the community for more Tongan women to become completely smokefree. Conclusions Tongan female smoking in New Zealand is comprised of experiences surrounding friendships, family and culture. This study concludes that although smoking harms are widely known, cessation service delivery can be transformed by utilizing existing Tongan cultural roles such as that of the mehikitanga (paternal aunt) to encourage non-smoking among extended female generations.


2021 ◽  
Vol 1 (2) ◽  
pp. 58-63
Author(s):  
Nurlin Abu Samah

Among the various arsenic sources in the environment, water may pose the greatest threat to human health. Arsenic and its compounds are known to have adverse health effects on humans, including skin cancer, bladder cancer, kidney cancer, and lung cancer, as well as vascular diseases of the legs and feet. There are a few separation methods that have been studied to remove arsenic species from water. Methods to remove arsenic species such as adsorption and ion exchange, coagulation and flocculation and membrane filtration have been developed to remove arsenic species from water. However, certain separation methods require a sophisticated equipment and are too expensive. From the different possible methods, this review is based in adsorption studies using imprinted polymer technology and economic sorbents as a media to remove arsenic from water. The details of adsorption processes for imprinted polymer technology have been discussed briefly and the comparative properties for arsenic species removal using different types of sorbents has been addressed significantly for being a user-friendly, highly extended and inexpensive methodology. However, a few drawbacks for each sorbent have been determined and the details was included in this review.


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