scholarly journals Static mechanical allodynia (SMA) is a paradoxical painful hypo-aesthesia: Observations derived from neuropathic pain patients treated with somatosensory rehabilitation

2008 ◽  
Vol 25 (1) ◽  
pp. 77-92 ◽  
Author(s):  
C. J. Spicher ◽  
F. Mathis ◽  
B. Degrange ◽  
P. Freund ◽  
E. M. Rouiller
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Static Mechanical ◽  
Pain Patients

scholarly journals Static mechanical allodynia in post-surgical neuropathic pain after breast cancer treatments

2020 ◽  
Vol 20 (4) ◽  
pp. 683-691
Author(s):  
Laura Mustonen ◽  
Tommi Aho ◽  
Hanna Harno ◽  
Eija Kalso
Keyword(s):  
Breast Cancer ◽  
Neuropathic Pain ◽  
Psychological Factors ◽  
Mechanical Allodynia ◽  
Cold Pressor Test ◽  
Pain Tolerance ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Cold Pain ◽  
Static Mechanical

AbstractObjectivesStatic mechanical allodynia (SMA), i. e., pain caused by normally non-painful static pressure, is a prevalent manifestation of neuropathic pain (NP). Although SMA may significantly affect the patient’s daily life, it is less well studied in the clinical context. We aimed to characterize SMA in women with chronic post-surgical NP (CPSNP) after breast cancer surgery. Our objective was to improve understanding of the clinical picture of this prevalent pain condition. This is a substudy of a previously published larger cohort of patients with intercostobrachial nerve injury after breast cancer surgery (Mustonen et al. Pain. 2019;160:246–56).MethodsWe studied SMA in 132 patients with CPSNP after breast cancer surgery. The presence, location, and intensity of SMA were assessed at clinical sensory examination. The patients gave self-reports of pain with the Brief Pain Inventory (BPI). We studied the association of SMA to type of surgery, oncological treatments, BMI, other pains, and psychological factors. General pain sensitivity was assessed by the cold pressor test.ResultsSMA was prevalent (84%) in this cohort whereas other forms of allodynia were scarce (6%). Moderate-to-severe SMA was frequently observed even in patients who reported mild pain in BPI. Breast and the side of chest were the most common locations of SMA. SMA was associated with breast surgery type, but not with psychological factors. Severe SMA, but not self-reported pain, was associated with lower cold pain tolerance.ConclusionsSMA is prevalent in post-surgical NP after breast cancer surgery and it may represent a distinct NP phenotype. High intensities of SMA may signal the presence of central sensitization.ImplicationsSMA should be considered when examining and treating patients with post-surgical NP after breast cancer surgery.

The perception threshold counterpart to dynamic and static mechanical allodynia assessed using von Frey filaments in peripheral neuropathic pain patients

2011 ◽  
Vol 2 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Åsa H. Landerholm ◽  
Per T. Hansson
Keyword(s):  
Neuropathic Pain ◽  
Nerve Block ◽  
Mechanical Allodynia ◽  
Threshold Level ◽  
Mechanical Stimulus ◽  
Perception Threshold ◽  
Static Mechanical ◽  
Continuous Nerve Block ◽  
C Fibre ◽  
Myelinated Fibres

AbstractBackground and aimPain due to a usually non-painful mechanical stimulus, mechanical allodynia, is an oppressive symptom in subgroups of patients with neuropathic pain. Dynamic mechanical allodynia (DMA) is evoked by a normally innocuous light moving mechanical stimulus on the skin and static mechanical allodynia (SMA) by a sustained, normally innocuous pressure against the skin. DMA is claimed to be mediated by myelinated fibres and SMA by C-fibres. Also A-delta fibres have been implicated in the static subtype. A low intensity vertically applied stimulus of 1 second (s) is expected to activate predominantly rapidly adapting A-beta mechanoreceptors thus recruiting the same peripheral substrate as a horizontally moving brush on top of the skin. In patients with SMA we assumed an activation of Cbut also A-delta fibres from a static 10 s von Frey filament stimulus. The aim was to investigate if DMA and SMA could be assessed at perception threshold level using short or longer lasting usually non-painful von Frey filament prodding of the neuropathic skin.Patients and methodsEighteen patients with painful unilateral partial peripheral traumatic nerve injury suffering from SMA (n= 9) and/or DMA (n= 18) in a limb were studied. A compression/ischemia-induced (differential) nerve block in conjunction with repeated quantitative sensory testing of A-delta and C-fibre function using cold and warm stimuli was used to assess which nerve fibre population that contributes to pain at perception threshold level using 1 s (vF1) and 10 s (vF10) von Frey filament stimulation of the skin.ResultsThe main outcome was the finding that elevation of vF1 and vF10 occurred simultaneously and significantly prior to an increase in the perception level to cold or warmth during the continuous nerve block. Single patients demonstrated a slight decrease in cold perception levels at the time of elevation of vF1 or vF10 and a possible contribution to mechanical allodynia from A-delta-fibres can therefore not completely be ruled out although the recorded alterations were minor. None of the patients reported an elevation of the perception level to warmth at the time of elevation of vF1 or vF10 excluding contribution from C-fibres. Further, only patients with clinically established SMA (n= 9) reported continuous pain to a sustained 10 s von Frey filament stimulation (vF10). Patients with only DMA (n= 9) reported pain merely for the initial 1–3 s of the total stimulus duration of 10 s and for a few seconds after the filament was lifted from the skin.ConclusionsThese findings support the role of A-beta fibres as peripheral mediators of both vF1 and vF10 although different receptor organs may be involved, i.e., rapidly (RA) and slowly (SA-I) adapting mechanoreceptors.ImplicationsTechniques to quantify the different allodynias at perception threshold level deserve further attention as possible adjuncts to suprathreshold stimuli in intervention studies aimed at modifying these stimulus-evoked phenomena.

The Effect of Blocking of Antidromic Impulses by Capsaicin on Mechanical Allodynia in a Rat Model of Peripheral Neuropathic Pain

2004 ◽  
Vol 17 (1) ◽  
pp. 5 ◽  
Author(s):  
Jin Woo Shin ◽  
Kyung Don Hahm ◽  
Joong Woo Leem ◽  
Chul Hoo Park ◽  
Seung Woo Ku ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Rat Model ◽  
Mechanical Allodynia ◽  
Peripheral Neuropathic Pain

scholarly journals Tongluo Zhitong Prescription Alleviates Allodynia, Hyperalgesia, and Dyskinesia in the Chronic Constriction Injury Model of Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Zhiyong Wang ◽  
Jianwei Wang ◽  
Lihua Qin ◽  
Weiguang Zhang
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Chronic Constriction Injury ◽  
Catgut Suture ◽  
Cold Allodynia ◽  
Injury Model ◽  
Neuropathic Pain Model ◽  
Gait Function ◽  
Chronic Constriction Injury Model ◽  
Heat Hyperalgesia

Neuropathic pain is common in clinical practice. Exploration of new drug therapeutics has always been carried out for more satisfactory effects and fewer side-effects. In the present study, we aimed to investigate effects of Tongluo Zhitong Prescription (TZP), a compounded Chinese medicine description, on neuropathic pain model of rats with chronic constriction injury (CCI). The CCI model was established by loosely ligating sciatic nerve with catgut suture, proximal to its trifurcation. The static and dynamic allodynia, heat hyperalgesia, mechanical allodynia, cold allodynia, and gait were assessed. Our results showed that TZP alleviated CCI-induced static and dynamic allodynia, suppressed heat hyperalgesia and cold and mechanical allodynia, and improved gait function. These results suggest that TZP could alleviate neuropathic pain. Further experiments are needed to explore its mechanisms.

scholarly journals Psychobehavioral and psychosocial aspects of neuropathic pain patients

Revista Dor ◽  
2016 ◽  
Vol 17 ◽  
Author(s):  
Dirce Maria Navas Perissinotti ◽  
Andrea Golfarb Portnoi
Keyword(s):  
Neuropathic Pain ◽  
Psychosocial Aspects ◽  
Pain Patients

Intravenous lidocaine infusions in a multidirectional model of treatment of neuropathic pain patients

2016 ◽  
Vol 68 (5) ◽  
pp. 1069-1075 ◽  
Author(s):  
Anna Przeklasa-Muszyńska ◽  
Magdalena Kocot-Kępska ◽  
Jan Dobrogowski ◽  
Maciej Wiatr ◽  
Joanna Mika
Keyword(s):  
Neuropathic Pain ◽  
Intravenous Lidocaine ◽  
Pain Patients

scholarly journals Plasticity-Related PKMζSignaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jeongsoo Han ◽  
Minjee Kwon ◽  
Myeounghoon Cha ◽  
Motomasa Tanioka ◽  
Seong-Karp Hong ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Nerve Injury ◽  
Neural Plasticity ◽  
Mechanical Allodynia ◽  
Insular Cortex ◽  
Long Term Potentiation ◽  
Inhibitory Peptide ◽  
Term Potentiation ◽  
Potential Applications

The insular cortex (IC) is associated with important functions linked with pain and emotions. According to recent reports, neural plasticity in the brain including the IC can be induced by nerve injury and may contribute to chronic pain. Continuous active kinase, protein kinase Mζ(PKMζ), has been known to maintain the long-term potentiation. This study was conducted to determine the role of PKMζin the IC, which may be involved in the modulation of neuropathic pain. Mechanical allodynia test and immunohistochemistry (IHC) of zif268, an activity-dependent transcription factor required for neuronal plasticity, were performed after nerve injury. Afterζ-pseudosubstrate inhibitory peptide (ZIP, a selective inhibitor of PKMζ) injection, mechanical allodynia test and immunoblotting of PKMζ, phospho-PKMζ(p-PKMζ), and GluR1 and GluR2 were observed. IHC demonstrated that zif268 expression significantly increased in the IC after nerve injury. Mechanical allodynia was significantly decreased by ZIP microinjection into the IC. The analgesic effect lasted for 12 hours. Moreover, the levels of GluR1, GluR2, and p-PKMζwere decreased after ZIP microinjection. These results suggest that peripheral nerve injury induces neural plasticity related to PKMζand that ZIP has potential applications for relieving chronic pain.

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