Demographic and Multimodal Imaging Features of Macular Telangiectasia Type 2: Korean Macular Telangiectasia Type 2 Study – Report No. 2

Purpose: To describe a case of macular telangiectasia type 2 (MacTel) presenting with decreased vision due to intraretinal/sub-internal limiting membrane (ILM) hemorrhage in the absence of neovascularization. Method: Clinical examination and multimodal imaging were performed. Results: A 65-year-old female presented with blurred left vision, recording 20/160 in that eye. There was intraretinal hemorrhage at the left macula centrally, with sub-ILM hemorrhage superiorly and inferiorly. Optical coherence tomography (OCT) showed no evidence of subretinal neovascularization. Imaging of the right macula was consistent with MacTel. The blood spontaneously cleared and the left visual acuity gradually improved to 20/25 by 4 months. Fluorescein angiography confirmed MacTel, and once the hemorrhage resolved, both inner and outer retinal cavitation was identified on OCT of the left macula. The left best-corrected visual acuity remained at 20/25 at 2-year follow-up. Conclusion: Spontaneous resorption of hemorrhage was accompanied by visual improvement.

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Choroidal thickness and vascular density in macular telangiectasia type 2 using enface swept-source optical coherence tomography

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-313414 ◽

2019 ◽

Vol 103 (11) ◽

pp. 1584-1589 ◽

Cited By ~ 1

Author(s):

Jay C Wang ◽

Inês Laíns ◽

Patrick Oellers ◽

Ivana K Kim ◽

Joan W Miller ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Thickness ◽

Fundus Photography ◽

Imaging Features ◽

Optical Coherence ◽

Swept Source ◽

Macular Telangiectasia ◽

Macular Telangiectasia Type 2 ◽

And Control

PurposeTo investigate the choroidal thickness (CT) and choroidal vascular densities (CVD) of patients with macular telangiectasia type 2 (MacTel2) and their association with other multimodal imaging features, using swept-source optical coherence tomography (SS-OCT).MethodsProspective, cross-sectional study. Consecutive patients with MacTel2 along with controls without any macular disease were included. Fundus photography, confocal blue reflectance, near-infrared reflectance, autofluorescence, fluorescein angiography, spectral domain OCT and SS-OCT were performed. Images were independently analysed by two graders, and CVD was calculated from binarised en face SS-OCT images. CT was obtained from the SS-OCT platform via built-in automated segmentation. Multilevel mixed-effects models were used for statistical analysis.ResultsThirty-nine eyes of 20 patients with MacTel2 and 29 eyes of 15 control patients were included. Average CT and perifoveal temporal CT did not differ significantly between eyes with MacTel2 and control eyes (p≥0.350), when accounting for confounding factors. Overall and temporal CVD also did not significantly differ between the two groups (p≥0.490).ConclusionCT and CVD did not significantly differ between MacTel2 and control eyes in this study using SS-OCT. Even though MacTel2 may include abnormalities involving the choroid, these are likely minor in comparison to the predominant retinal changes.

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Idiopathic macular telangiectasia type 2, stage V or proliferative stage: Multimodal imaging

Journal Français d Ophtalmologie ◽

10.1016/j.jfo.2021.02.020 ◽

2021 ◽

Author(s):

J.L. Sánchez-Vicente ◽

J. de las Morenas-Iglesias ◽

B. González-Jáuregui-López ◽

T. Rueda-Rueda ◽

Á. Espiñeira-Periñán ◽

...

Keyword(s):

Multimodal Imaging ◽

Macular Telangiectasia ◽

Proliferative Stage ◽

Macular Telangiectasia Type 2 ◽

Idiopathic Macular Telangiectasia

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Multimodal imaging of macular telangiectasia type 2 in a pediatric patient

American Journal of Ophthalmology Case Reports ◽

10.1016/j.ajoc.2021.101082 ◽

2021 ◽

pp. 101082

Author(s):

Magdy Moussa ◽

Mahmoud Leila ◽

Omar Moussa

Keyword(s):

Pediatric Patient ◽

Multimodal Imaging ◽

Macular Telangiectasia ◽

Macular Telangiectasia Type 2

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Multimodal characterization of macular telangiectasia type 2 and correlation with multifocal electroretinogram

10.21203/rs.3.rs-178402/v1 ◽

2021 ◽

Author(s):

Apoorva Ayachit ◽

Lakshmipriya Uday Reddy ◽

Shrinivas Joshi ◽

Guruprasad Ayachit

Keyword(s):

Multimodal Imaging ◽

Multifocal Electroretinogram ◽

Imaging Systems ◽

Control Group ◽

Macular Telangiectasia ◽

Macular Telangiectasia Type 2 ◽

Stage 1 ◽

Sd Oct

Abstract 1. Purpose: To study the correlation of multimodal imaging in macular telangiectasia (Mac Tel) with foveal function on multifocal electroretinogram (mfERG)2. Methods: Eyes with non- proliferative Mac Tel diagnosed based on clinical examination, optical coherence tomography (OCT), autofluorescence (AF), fluorescein angiography (FA), OCT angiography (OCTA). Control group with normal eye exam included for multifocal electroretinogram.Staging of OCT, OCTA, AF and FA done in Mac Tel subjects. mfERG done in study subjects and controls. Correlation of imaging modalities and P1 amplitudes at fovea (ring 1) studied in terms of correlation co-efficient.3. Results: Twenty nine eyes of 16 patients of Mac Tel and 25 eyes of 19 controls were included. BCVA was 0.38 ± 0.266 in study eyes and 0 in control eyes. On OCT it was observed that 41.4% Mac Tel eyes (n = 12) belonged to stage 3, 37.9%(n = 11)) eyes belonged to stage 2 and 20.7% (n = 6) eyes belonged to stage 1. AF- Stage 3 comprised of 75.9% eyes (n = 22); 4 eyes belonged to stage 2 and 3 eyes to stage 1. On FA, 18 eyes belonged to stage 3 (62.1%); stage 2 was seen in 1 (3.4%) eye and stage 1 was seen in 10 (34.5%) eyes. There was decrease in P1 amplitudes from R1(p < 0.001), R2( 0.001), R3 (< 0.001) and R4 (0.001) in Mac Tel eyes compared to control eyes but not in R5 (p 0.785). SD- OCT had positive correlation with FAF (CC 0.747,p < 0.001) FFA (CC 0.775, p < 0.001) and R1P1 (CC 0.682, p < 0.001). With OCTA there was no significant correlation (CC 0.318, p 0.093). There was positive and significant correlation of OCT (0.682,<0.001), OCTA (0.379,p 0.042) AF ( 0.635, p < 0.001) and FA (0.495, p < 0.006) with R1P1.4. Conclusions: Existing multimodal imaging systems can be reliable indicators of foveal function as on mfERG.

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