Pilot study of tolerability and safety of opioid receptor antagonists as novel therapies for chronic pain among persons living with HIV with past year heavy drinking: a randomized controlled trial

AIDS Care ◽  
2021 ◽  
pp. 1-10
Author(s):  
Sally Bendiks ◽  
Debbie M. Cheng ◽  
Elena Blokhina ◽  
Marina Vetrova ◽  
Elena Verbitskaya ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Randomized Controlled Trial ◽  
Pilot Study ◽  
Controlled Trial ◽  
Heavy Drinking ◽  
Novel Therapies ◽  
Randomized Controlled ◽  
Opioid Receptor Antagonists ◽  
Persons Living With Hiv ◽  
Living With Hiv

scholarly journals Pilot study evaluating a brief mindfulness intervention for those with chronic pain: study protocol for a randomized controlled trial

Trials ◽  
2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Ana Howarth ◽  
Linda Perkins-Porras ◽  
Jared G. Smith ◽  
Jeevakan Subramaniam ◽  
Claire Copland ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Randomized Controlled Trial ◽  
Pilot Study ◽  
Study Protocol ◽  
Controlled Trial ◽  
Mindfulness Intervention ◽  
Randomized Controlled

Non-linear resistance training reduces inflammatory biomarkers in persons living with HIV: A randomized controlled trial

2016 ◽  
Vol 16 (8) ◽  
pp. 1232-1239 ◽  
Author(s):  
Hugo Ribeiro Zanetti ◽  
Lucas Gonçalves da Cruz ◽  
Camilo Luís Monteiro Lourenço ◽  
Fernando de Freitas Neves ◽  
Mário Leon Silva-Vergara ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Resistance Training ◽  
Controlled Trial ◽  
Inflammatory Biomarkers ◽  
Randomized Controlled ◽  
Linear Resistance ◽  
Persons Living With Hiv ◽  
Non Linear ◽  
Living With Hiv

scholarly journals Nurse-Delivered Cognitive Behavioral Therapy for Adherence and Depression Among People Living With HIV (the Ziphamandla Study): Protocol for a Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
John A Joska ◽  
Lena S Andersen ◽  
Rosana Smith-Alvarez ◽  
Jessica Magidson ◽  
Jasper S Lee ◽  
...  
Keyword(s):  
South Africa ◽  
Randomized Controlled Trial ◽  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Controlled Trial ◽  
Art Adherence ◽  
First Line ◽  
Randomized Controlled ◽  
Persons Living With Hiv ◽  
Living With Hiv

BACKGROUND There is an unmet need to develop effective, feasible, and scalable interventions for poor adherence and depression in persons living with HIV in low- and middle-income countries (LMIC). OBJECTIVE This study aims to investigate the effectiveness of a nurse-delivered cognitive behavioral therapy (CBT) intervention for adherence and depression (CBT-AD) among persons living with HIV who are failing first-line antiretroviral therapy (ART) in Cape Town, South Africa. METHODS This study is a 2-arm randomized controlled trial of CBT-AD integrated into the HIV primary care setting in South Africa. A total of 160 participants who did not achieve viral suppression from their first-line ART and have a unipolar depressive mood disorder will be randomized to receive either 8 sessions of CBT-AD or enhanced treatment as usual. Participants will be assessed for major depressive disorder using the Mini International Neuropsychiatric Interview at baseline and 4, 8, and 12 months. The primary outcomes are depression on the Hamilton Depression Scale (HAM-D; as assessed by a blinded assessor) at the 4-month assessment and changes in ART adherence (assessed via real-time, electronic monitoring with Wisepill) between baseline and the 4-month assessment. Secondary outcomes are HIV viral load and CD4 cell count at the 12-month assessment as well as ART adherence (Wisepill) and depression (HAM-D) over follow-up (4-, 8-, and 12-month assessments). RESULTS The trial commenced in August 2015 and recruitment began in July 2016. Enrollment was completed in June 2019. CONCLUSIONS Results of this study will inform whether an existing intervention (CBT-AD) can be effectively administered in LMIC by nurses with training and ongoing supervision. This will present unique opportunities to further explore the scale-up of a behavioral intervention to enhance ART adherence among persons living with HIV with major depression in a high-prevalence setting, to move toward achieving The Joint United Nations Programme on HIV/AIDS 90-90-90 goals. CLINICALTRIAL ClincialTrials.gov NCT02696824; https://clinicaltrials.gov/ct2/show/NCT02696824 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/14200

A Randomized Controlled Trial of a Rapid Re-housing Intervention for Homeless Persons Living with HIV/AIDS: Impact on Housing and HIV Medical Outcomes

2019 ◽  
Vol 23 (9) ◽  
pp. 2315-2325 ◽  
Author(s):  
Vivian L. Towe ◽  
Ellen Weiss Wiewel ◽  
Yaoyu Zhong ◽  
Sebastian Linnemayr ◽  
Rachel Johnson ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Homeless Persons ◽  
Medical Outcomes ◽  
Randomized Controlled ◽  
Persons Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Nurse-Delivered Cognitive Behavioral Therapy for Adherence and Depression Among People Living With HIV (the Ziphamandla Study): Protocol for a Randomized Controlled Trial

10.2196/14200 ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. e14200 ◽  
Author(s):  
John A Joska ◽  
Lena S Andersen ◽  
Rosana Smith-Alvarez ◽  
Jessica Magidson ◽  
Jasper S Lee ◽  
...  
Keyword(s):  
South Africa ◽  
Randomized Controlled Trial ◽  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Controlled Trial ◽  
Art Adherence ◽  
First Line ◽  
Randomized Controlled ◽  
Persons Living With Hiv ◽  
Living With Hiv

Background There is an unmet need to develop effective, feasible, and scalable interventions for poor adherence and depression in persons living with HIV in low- and middle-income countries (LMIC). Objective This study aims to investigate the effectiveness of a nurse-delivered cognitive behavioral therapy (CBT) intervention for adherence and depression (CBT-AD) among persons living with HIV who are failing first-line antiretroviral therapy (ART) in Cape Town, South Africa. Methods This study is a 2-arm randomized controlled trial of CBT-AD integrated into the HIV primary care setting in South Africa. A total of 160 participants who did not achieve viral suppression from their first-line ART and have a unipolar depressive mood disorder will be randomized to receive either 8 sessions of CBT-AD or enhanced treatment as usual. Participants will be assessed for major depressive disorder using the Mini International Neuropsychiatric Interview at baseline and 4, 8, and 12 months. The primary outcomes are depression on the Hamilton Depression Scale (HAM-D; as assessed by a blinded assessor) at the 4-month assessment and changes in ART adherence (assessed via real-time, electronic monitoring with Wisepill) between baseline and the 4-month assessment. Secondary outcomes are HIV viral load and CD4 cell count at the 12-month assessment as well as ART adherence (Wisepill) and depression (HAM-D) over follow-up (4-, 8-, and 12-month assessments). Results The trial commenced in August 2015 and recruitment began in July 2016. Enrollment was completed in June 2019. Conclusions Results of this study will inform whether an existing intervention (CBT-AD) can be effectively administered in LMIC by nurses with training and ongoing supervision. This will present unique opportunities to further explore the scale-up of a behavioral intervention to enhance ART adherence among persons living with HIV with major depression in a high-prevalence setting, to move toward achieving The Joint United Nations Programme on HIV/AIDS 90-90-90 goals. Trial Registration ClincialTrials.gov NCT02696824; https://clinicaltrials.gov/ct2/show/NCT02696824 International Registered Report Identifier (IRRID) DERR1-10.2196/14200

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