scholarly journals In-silico investigation of airflow and micro-particle deposition in human nasal airway pre- and post-virtual transnasal sphenoidotomy surgery

2021 ◽  
pp. 1-15
Author(s):  
Khashayar Moshksayan ◽  
Hojat Bahmanzadeh ◽  
Mohammad Faramarzi ◽  
Sasan Sadrizadeh ◽  
Goodarz Ahmadi ◽  
...  
Keyword(s):  
In Silico ◽  
Particle Deposition ◽  
Nasal Airway

scholarly journals Replacement Strategies for Animal Studies in Inhalation Testing

Sci ◽  
2021 ◽  
Vol 3 (4) ◽  
pp. 45
Author(s):  
Eleonore Fröhlich
Keyword(s):  
Animal Models ◽  
In Silico ◽  
Particle Deposition ◽  
Drug Testing ◽  
Animal Studies ◽  
Inhalation Exposure ◽  
Animal Testing ◽  
The Future

Animal testing is mandatory in drug testing and is the gold standard for toxicity and efficacy evaluations. This situation is expected to change in the future as the 3Rs principle, which stands for the replacement, reduction, and refinement of the use of animals in science, is reinforced by many countries. On the other hand, technologies for alternatives to animal testing have increased. The need to develop and use alternatives depends on the complexity of the research topic and also on the extent to which the currently used animal models can mimic human physiology and/or exposure. The lung morphology and physiology of commonly used animal species differs from that of human lungs, and the realistic inhalation exposure of animals is challenging. In vitro and in silico methods can assess important aspects of the in vivo effects, namely particle deposition, dissolution, action at, and permeation through, the respiratory barrier, and pharmacokinetics. This review discusses the limitations of animal models and exposure systems and proposes in vitro and in silico techniques that could, when used together, reduce or even replace animal testing in inhalation testing in the future.

scholarly journals Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part I: Inertial Regime Particles

2004 ◽  
Vol 38 (11) ◽  
pp. 1063-1071 ◽  
Author(s):  
James T. Kelly ◽  
Bahman Asgharian ◽  
Julia S. Kimbell ◽  
Brian A. Wong
Keyword(s):  
Particle Deposition ◽  
Nasal Airway ◽  
Inertial Regime

scholarly journals Estimation of Particle Deposition in the Airways from Different Inhaler Formulations Using an In Silico Model

2011 ◽  
Vol 29 (0) ◽  
pp. 107-117 ◽  
Author(s):  
Hugh D.C. Smyth ◽  
Ted B. Martonen ◽  
Kristin K. Isaacs ◽  
Anthony J. Hickey
Keyword(s):  
In Silico ◽  
Particle Deposition ◽  
In Silico Model

scholarly journals Airflow and Particle Deposition Simulations in Health and Emphysema: From In Vivo to In Silico Animal Experiments

2013 ◽  
Vol 42 (4) ◽  
pp. 899-914 ◽  
Author(s):  
Jessica M. Oakes ◽  
Alison L. Marsden ◽  
Celine Grandmont ◽  
Shawn C. Shadden ◽  
Chantal Darquenne ◽  
...  
Keyword(s):  
In Silico ◽  
Particle Deposition ◽  
Animal Experiments

Fibrous particle deposition in human nasal passage: The influence of particle length, flow rate, and geometry of nasal airway

2008 ◽  
Vol 39 (12) ◽  
pp. 1040-1054 ◽  
Author(s):  
Zuocheng Wang ◽  
Philip K. Hopke ◽  
Goodarz Ahmadi ◽  
Yung-Sung Cheng ◽  
Paul A. Baron
Keyword(s):  
Flow Rate ◽  
Particle Deposition ◽  
Nasal Passage ◽  
Nasal Airway ◽  
Particle Length

scholarly journals Replacement Strategies for Animal Studies in Inhalation Testing

2021 ◽  
Author(s):  
Eleonore Fröhlich
Keyword(s):  
Animal Models ◽  
In Silico ◽  
Particle Deposition ◽  
Drug Testing ◽  
Animal Studies ◽  
Inhalation Exposure ◽  
The Future ◽  
In Silico Models

Testing in animals is mandatory in drug testing and the gold standard for evaluation of toxicity. This situation is expected to change in the future because the 3Rs principle, which stands for replacement, reduction and refinement of the use of animals in science, is reinforced by many countries. On the other hand, technologies for alternatives to animals experiments have increased. The necessity to develop and use of alternatives is influenced by the complexity of the research topic and also by the fact, to which extent the currently used animal models can mimic human physiology and/or exposure. Rodent lung morphology and physiology differs markedly for that of humans and inhalation exposure of the animals are challenging. In vitro and in silico methods can assess important aspects of the in vivo action, namely particle deposition, dissolution, action at and permeation across the respiratory barrier and pharmacokinetics. Out of the numerous homemade in vitro and in silico models some are available commercially or open access. This review discusses limitations of animal models and exposure systems and proposes a panel of in vitro and in silico techniques that, in the future, may replace animal experimentation in inhalation testing.

Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part II: Ultrafine Particles

2004 ◽  
Vol 38 (11) ◽  
pp. 1072-1079 ◽  
Author(s):  
James T. Kelly ◽  
Bahman Asgharian ◽  
Julia S. Kimbell ◽  
Brian A. Wong
Keyword(s):  
Ultrafine Particles ◽  
Particle Deposition ◽  
Nasal Airway

In silico prototype of a human lung with a single airway to predict particle deposition

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Ana Fernández‐Tena ◽  
Raúl Barrio‐Perotti ◽  
Eduardo Blanco‐Marigorta ◽  
Adrián Pandal‐Blanco
Keyword(s):  
In Silico ◽  
Particle Deposition ◽  
Human Lung
Sign in / Sign up

Export Citation Format

Share Document