Effect of the nasal vestibule on particle deposition in a model of a human nasal airway

Hysteresis of the nasal airway pressure-flow relationship (PFR) is seen during hyperpnea, with lower nasal resistance during increasing inspiratory flow than during decreasing flow. We hypothesized that the nasal PFR hysteresis arose in the nasal vestibule airway because of progressive collapse during the inspiration. We measured the inspiratory transnasal and transvestibular PFR for one nasal passage in five normal subjects breathing via a nasal mask during voluntary hyperventilation, both with voluntary nostril flaring and without flaring. The inspiratory hysteresis (IH) was quantified as the ratio of the areas under the descending and ascending pressure-flow curves. Flaring reduced the vestibular IH from 1.96 ± 0.06 to 1.15 ± 0.06 and the nasal IH from 2.05 ± 0.13 to 1.28 ± 0.06 (both P < 0.01). Our results demonstrate that hysteresis arises in the compliant vestibule segment of the nasal airway, likely because of progressive collapse of the nasal vestibule during inspiration. The findings suggest that hysteresis is prevented by voluntary nostril flaring maintained throughout inspiration.

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Numerical simulation of airflow and micro-particle deposition in human nasal airway pre- and post-virtual sphenoidotomy surgery

Computers in Biology and Medicine ◽

10.1016/j.compbiomed.2015.03.015 ◽

2015 ◽

Vol 61 ◽

pp. 8-18 ◽

Cited By ~ 28

Author(s):

Hojat Bahmanzadeh ◽

Omid Abouali ◽

Mohammad Faramarzi ◽

Goodarz Ahmadi

Keyword(s):

Numerical Simulation ◽

Particle Deposition ◽

Nasal Airway

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Sinonasal Distribution of Topically Applied Particles: Computerized Tomographic Detection and the Effects of Topical Decongestion

Otolaryngology ◽

10.1016/j.otohns.2005.08.024 ◽

2005 ◽

Vol 133 (6) ◽

pp. 944-948 ◽

Cited By ~ 11

Author(s):

Dogan Senocak ◽

Mustafa Senocak ◽

Serkan Bozan

Keyword(s):

Particle Deposition ◽

Particle Distribution ◽

Middle Turbinate ◽

Inferior Turbinate ◽

Ct Imaging ◽

Middle Meatus ◽

Particle Detection ◽

Nasal Vestibule ◽

Positive Effects ◽

Osteomeatal Complex

OBJECTIVE: Determine the efficacy of computerized tomography (CT) in detecting the intranasal distribution of sprayed radio-enhanced particles and the effects of topical decongestion on particle distribution. STUDY DESIGN: Sinonasal distribution of a radio-enhanced spray solution was studied using CT imaging in 14 adults with no sinonasal symptoms. One nostril was sprayed with oximetazoline 5 minutes prior to particle application. Serial CT imaging of the sinonasal cavity in approximately 11 minutes was carried out to detect particle distribution into the nasal vestibule, turbinate surfaces, middle meatus and osteomeatal complex area, and the nasopharynx. RESULTS: Particle detection within the nasal vestibule was possible in all cases while distribution into the anterior nasal chamber was visible in 22 cases. Particles could be detected on the inferior turbinate in 7 nasal cavities (25%) and in only 2 cases on the middle turbinate (7.5%). Particles were detected in the middle meatus in 1 case and in no instances in the osteomeatal complex area. Oximetazoline application reduced the amount of particle deposition on the inferior turbinate but did not enhance distribution on the middle turbinate or into the middle meatus. CONCLUSION: Detection of radio-enhanced sprayed particles within the sinonasal cavity using CT imaging can be a reliable method to study the principles of intranasal particle distribution. Our study failed to show particle distribution into OMC, or any positive effects of nasal decongestion on particle distribution. EBM RATING: C

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