The Blood Pressure-Lowering Effect and Safety of Chlorogenic Acid from Green Coffee Bean Extract in Essential Hypertension

2006 ◽  
Vol 28 (5) ◽  
pp. 439-449 ◽  
Author(s):  
Takuya Watanabe ◽  
Yoichi Arai ◽  
Yuki Mitsui ◽  
Tatsuya Kusaura ◽  
Wataru Okawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Chlorogenic Acid ◽  
Coffee Bean ◽  
Green Coffee ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Pressure Lowering ◽  
Green Coffee Bean Extract ◽  
Green Coffee Bean

Effects of Indomethacin Alone and during Diuretic or β-Adrenoreceptor-Blockade Therapy on Blood Pressure and the Renin System in Essential Hypertension

1978 ◽  
Vol 55 (s4) ◽  
pp. 203s-205s ◽  
Author(s):  
J. A. Lopez-Ovejero ◽  
M. A. Weber ◽  
J. I. M. Drayer ◽  
J. E. Sealey ◽  
J. H. Laragh
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Water Retention ◽  
Antihypertensive Effect ◽  
Renin Secretion ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Uncomplicated Hypertension ◽  
Pressure Lowering ◽  
Propranolol Therapy

1. Indomethacin was administered alone or in addition to either diuretic or propranolol therapy to three groups of patients with essential hypertension on a free sodium diet. 2. Indomethacin administration reduced renin secretion by about 30% in untreated uncomplicated hypertensive patients and by about 75% in those whose renin secretion had either been stimulated or suppressed by maintained diuretic or β-adrenoreceptor-blockade therapy. 3. Indomethacin administration produced no net effect on blood pressure in untreated patients with uncomplicated hypertension but it blunted or reversed the antihypertensive effect of either diuretic or propranolol therapy. 4. Salt and water retention may be an important factor in the blood pressure-raising effect of indomethacin during diuretic or propranolol therapy: In addition, prostaglandin synthesis may be important in counteracting increased α-adrenergic tone, which may limit the blood pressure-lowering effect of β-adrenoreceptor-blockade. 5. Because of these interactions and their pressor potential indomethacin should be used with caution when combined with either diuretics or β-adrenoreceptor blockers.

Bioactivity of Fermented Green Coffee Bean Extract Containing High Chlorogenic Acid and Surfactin

2019 ◽  
Vol 22 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Boyong Kim ◽  
Dong Sook Lee ◽  
Hyeong Seok Kim ◽  
Taegun Park ◽  
Jin Kwan Kim ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Coffee Bean ◽  
Green Coffee ◽  
Green Coffee Bean Extract ◽  
Green Coffee Bean
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