First report of isolation of maleamic acid from natural source Polygonatum cirrhifolium—A potential chemical marker for identification

Seven compounds were isolated from the leaves and fruits of Egyptian Withania somnifera dunal, (Family: Solanaceae). The identity of the compounds based on their spectroscopic data were as follows: two withanolides; withaperuvin C (1), phyperunolideF (2) and four lipids;1,2-di-O-palmitoyl-3-O-(6´´´-sulfo-α-D-quinovopyranosyl)-glycerol (3), vaccenic acid (5), 1,3 dicaproyl,2-vaccenoyl-glycerol (6), vaccenolymonoglyceride (7) and β-sitosterol glucoside (4). All the isolated metabolites except (4) were reported for the first time from this plant. Besides, this is the first report for isolation of compounds (6, 7) in a pure form from a natural source. Different fractions of the fruits of the Egyptian plant were investigated for their anticholinesterase activities where the most potent ones found to be the aqueous, the light petroleum fraction in addition to a mixture of lipids.

Download Full-text

Polar Alkaloids from the Caribbean Marine Sponge Niphates Digitalis

Natural Product Communications ◽

10.1177/1934578x1000500807 ◽

2010 ◽

Vol 5 (8) ◽

pp. 1934578X1000500 ◽

Cited By ~ 1

Author(s):

Erik L. Regalado ◽

Judith Mendiola ◽

Abilio Laguna ◽

Clara Nogueiras ◽

Olivier P. Thomas

Keyword(s):

Marine Sponge ◽

Spectroscopic Data ◽

Natural Source ◽

Flash Chromatography ◽

First Report ◽

Data Analyses ◽

Rp Hplc ◽

The Caribbean

A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7-ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.

Download Full-text

Isolation of Chemical Marker from Fritillaria roylei: First Report

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.03.198 ◽

2020 ◽

Vol 12 (03) ◽

Keyword(s):

Chemical Marker ◽

First Report

Download Full-text

Isolation and Quantification of Chemical Marker of Polygonatum verticillatum: First Report

Current Traditional Medicine ◽

10.2174/2215083803666161209145620 ◽

2017 ◽

Vol 2 (3) ◽

pp. 216-224 ◽

Cited By ~ 2

Author(s):

Jaswinder Kaur Virk ◽

Parveen Bansal ◽

Sanjiv Kumar ◽

Ranjit Singh ◽

Ravindra Rawal

Keyword(s):

Chemical Marker ◽

First Report ◽

Polygonatum Verticillatum

Download Full-text

Xanthones from aerial parts of Hypericum laricifolium Juss

Natural Product Communications ◽

10.1177/1934578x1300801218 ◽

2013 ◽

Vol 8 (12) ◽

pp. 1934578X1300801 ◽

Cited By ~ 1

Author(s):

Irama Ramírez-González ◽

Juan Manuel Amaro-Luis ◽

Alí Bahsas

Keyword(s):

Vanillic Acid ◽

Betulinic Acid ◽

Mass Spectrometric ◽

Natural Source ◽

First Report ◽

Aerial Parts

From the aerial parts of Hypericum laricifolium Juss., twelve compounds were isolated and identified. They were the xanthones: 1-hydroxy-7-methoxy-xanthone (1), 1,7-dihydroxy-xanthone (2), 2-hydroxy-xanthone (3), 6-deoxyisojacareubin (4), 1,3-dihydroxy-6-methoxy-xanthone (6), and 1,5,6-trihydroxy-7-methoxy-xanthone (7), together with β-sitosterol, betulinic acid, vanillic acid, isoquercitrin and a mixture of quercetin and isorhamnetin. All the compounds were characterized by spectroscopic and mass spectrometric methods, and by comparison with literature data. Thisis the first report on the presence of xanthones in H.laricifolium. 1,3-Dihydroxy-6-methoxy-xanthone has been previously synthesized, but this is the first report of its isolation from a natural source.

Download Full-text

Dolabellane Diterpenes from Cleome Droserifolia

Natural Product Communications ◽

10.1177/1934578x0800300915 ◽

2008 ◽

Vol 3 (9) ◽

pp. 1934578X0800300 ◽

Cited By ~ 2

Author(s):

Hoda M. Fathy ◽

Mohamed I. Aboushoer ◽

Fathallah M. Harraz ◽

Abdallah A. Omar ◽

Gilles Goetz ◽

...

Keyword(s):

Methyl Ester ◽

Glutaric Acid ◽

Natural Source ◽

Compound I ◽

Chemical Methods ◽

First Report ◽

Chemical Structures ◽

Flavone Derivatives ◽

Derivatives Of

Three diterpenoid dolabellane esters were isolated from Cleome droserifolia. The chemical structures of the isolated compounds were determined by spectral as well as chemical methods. These dolabellanes (I, II and III) are ester derivatives of 3-hydroxy-3-methyl glutaric acid (3-HMGA). Compounds I and II have the second (3HMGA) carboxyl function free, while compound III is the methyl ester of compound I. This is the first report of the isolation of this class of compounds from the genus Cleome and is the first report of the isolation of compound III from a natural source. In addition, eight flavone derivatives were isolated.

Download Full-text

A fossil Aspergillus from Eocene Dominican amber

Journal of Paleontology ◽

10.1017/s0022336000058996 ◽

1988 ◽

Vol 62 (01) ◽

pp. 141-143 ◽

Cited By ~ 15

Author(s):

Gerard M. Thomas ◽

George O. Poinar

Keyword(s):

Dominican Republic ◽

Fossil Species ◽

First Report ◽

Dominican Amber ◽

Eocene Amber

A sporulating Aspergillus is described from a piece of Eocene amber originating from the Dominican Republic. The Aspergillus most closely resembles a form of the white spored phase of Aspergillus janus Raper and Thom. This is the first report of a fossil species of Aspergillus.

Download Full-text