scholarly journals Chemical Constituents of Egyptian Withania Somnifera Leaves and Fruits and their Anticholinesterase Activity

2019 ◽  
Vol 63 (4) ◽  
Author(s):  
Rahma S. Mahrous ◽  
Hoda M. Fathy ◽  
RASHA M. ABU EL-KHAIR ◽  
ABDALLAH A. OMAR
Keyword(s):  
Spectroscopic Data ◽  
Withania Somnifera ◽  
Vaccenic Acid ◽  
Chemical Constituents ◽  
Light Petroleum ◽  
Natural Source ◽  
Petroleum Fraction ◽  
Anticholinesterase Activity ◽  
First Report ◽  
First Time

Seven compounds were isolated from the leaves and fruits of Egyptian Withania somnifera dunal, (Family: Solanaceae). The identity of the compounds based on their spectroscopic data were as follows: two withanolides; withaperuvin C (1), phyperunolideF (2) and four lipids;1,2-di-O-palmitoyl-3-O-(6´´´-sulfo-α-D-quinovopyranosyl)-glycerol (3), vaccenic acid (5), 1,3 dicaproyl,2-vaccenoyl-glycerol (6), vaccenolymonoglyceride (7) and β-sitosterol glucoside (4). All the isolated metabolites except (4) were reported for the first time from this plant. Besides, this is the first report for isolation of compounds (6, 7) in a pure form from a natural source. Different fractions of the fruits of the Egyptian plant were investigated for their anticholinesterase activities where the most potent ones found to be the aqueous, the light petroleum fraction in addition to a mixture of lipids.

Antidiabetic and Antioxidant Activities of Major Flavonoids of Cynanchum acutum L. (Asclepiadaceae) Growing in Egypt

2008 ◽  
Vol 63 (9-10) ◽  
pp. 658-662 ◽  
Author(s):  
Ghada A. Fawzy ◽  
Hossam M. Abdallah ◽  
Mohamed S. A. Marzouk ◽  
Fathy M. Soliman ◽  
Amany A. Sleem
Keyword(s):  
Blood Glucose ◽  
Spectroscopic Data ◽  
Methanolic Extract ◽  
Antioxidant Activities ◽  
First Report ◽  
Insulin Levels ◽  
Butanol Fraction ◽  
Aerial Parts ◽  
First Time

Seven flavonoids were isolated from the butanol fraction of the methanolic extract of the aerial parts of Cynanchum acutum L. (Asclepiadaceae). All of which have been isolated for the first time from the genus Cynanchum. Their structures were established as quercetin 3-O-β-galacturonopyranoside (1), quercetin 7-O-β-glucopyranoside (2), tamarixtin 3-O-β-galacturonopyranoside (3), kaempferol 3-O-β-galacturonopyranoside (4), 8-hydroxyquercetin 3-O-β-galactopyranoside (5), tamarixtin 3-O-α-rhamnopyranoside (6), and tamarixtin 7-O-α-arabinopyranoside (7) on the basis of their chromatographic properties, chemical and spectroscopic data. The major isolated flavonoids 1, 2 and 3 were found to exhibit significant antioxidant and antidiabetic activities (by measuring blood glucose and insulin levels). This is the first report about the antioxidant and antidiabetic activities of compounds 1 - 3.

scholarly journals Chemical Constituents and Derivatization of Melodorinol from the Roots of Melodorum fruticosum

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000
Author(s):  
Siriwat Hongnak ◽  
Jongkolnee Jongaramruong ◽  
Suttira Khumkratok ◽  
Pongpun Siriphong ◽  
Santi Tip-pyang
Keyword(s):  
Cell Lines ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Chemical Investigation ◽  
Crude Extracts ◽  
First Time ◽  
Mcf 7

Chemical investigation of the CH2Cl2 and MeOH crude extracts of the roots of Melodorum fruticosum Lour. led to the isolation of 15 known compounds, of which 5, 10, and 12-15 are reported for the first time from this plant. In addition, melodorinol (7) was derivatized to afford six new (7a-7d and 7f-7g) analogues and one known compound (7e). Their structures were identified on the basic of spectroscopic data. Most of them were evaluated for their cytotoxicity against KB, HeLa, MCF-7 and HepG-2 cell lines. Compounds 4 and 7b were the most potent to all cell lines.

scholarly journals Chemical Constituents of the Insecticidal Active Extract of Tinospora crispa

2019 ◽  
Vol 10 (1) ◽  
pp. 23
Author(s):  
Nor Aziyah Bakhari ◽  
Siti Nur Amirah Diana Fadzillah ◽  
Norain Isa
Keyword(s):  
Blood Pressure ◽  
Petroleum Ether ◽  
Silica Gel ◽  
1H Nmr ◽  
Column Chromatography ◽  
Mobile Phase ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Ethanol Extract ◽  
First Time

Tinospora crispa Miers (Menispermaceae) is a climbing vine with stems rich in warts. The plant is called Akar Seruntum or Patawali in Malaysia and is widely used for treating skin complaints, malaria, bacterial abscess, high blood pressure and diabetes. In the present study, the stems of T. crispa were collected from the locality and succesively extracted with petroleum ether, followed by chloroform and ethanol. The insecticidal active extract (ethanol extract) was  subjected to column chromatography of silica gel eluted with a gradient mobile phase containing hexane, chloroform and ethanol. Among the chemical constituents isolated are n-tetracosyl trans-ferulate and n-octacosyl alcohol, along with three known aporphine alkaloids; N-formylnornuciferine, N-acetylnornuciferine and lysicamine. All compounds were identified by comparing their spectroscopic data (UV, IR, 1H NMR, MS) with data from corresponding values in the literature. Isolation of n-tetracosyl trans-ferulate and n-octacosyl alcohol is reported the first time for T. crispa.

scholarly journals Polar Alkaloids from the Caribbean Marine Sponge Niphates Digitalis

2010 ◽  
Vol 5 (8) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Erik L. Regalado ◽  
Judith Mendiola ◽  
Abilio Laguna ◽  
Clara Nogueiras ◽  
Olivier P. Thomas
Keyword(s):  
Marine Sponge ◽  
Spectroscopic Data ◽  
Natural Source ◽  
Flash Chromatography ◽  
First Report ◽  
Data Analyses ◽  
Rp Hplc ◽  
The Caribbean

A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7-ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.

Chemical constituents from the bark of Anisopus mannii

2009 ◽  
Vol 87 (2) ◽  
pp. 397-400 ◽  
Author(s):  
Apollinaire Tsopmo ◽  
Pierre Kamnaing ◽  
Jean Watchueng ◽  
Jin-Ming Gao ◽  
Yasuo Konishi ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Acetone Extract ◽  
A Minor ◽  
First Time

A minor novel 1,7-naphthyridine alkaloid with an unprecedented skeleton, named anisopusine (1), was isolated from the CH2Cl2 soluble materials of an acetone extract of the bark of Anisopus mannii (Asclepiadaceae) together with four known compounds 5α-hydroxy-lup-20(29)-en-3β-yl eicosanoate (2), [6]-gingerdione (3), [6]-dehydrogingerdione (4), and ferulic acid (5). Their structures were determined on the basis of spectroscopic data, including 1D and 2D NMR, HR-EI-MS. Compounds (2–5) were characterized for the first time from this genus.

Identification of Biflavones in Ethyl Acetate Fraction from Ethanol Extract of Selaginella doederleinii Hieron

2012 ◽  
Vol 550-553 ◽  
pp. 1862-1865
Author(s):  
Yan Zhang ◽  
Li Yang ◽  
Lin Wang
Keyword(s):  
Physicochemical Properties ◽  
Ethyl Acetate ◽  
Dimethyl Ether ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Chemical Structures ◽  
Trimethyl Ether ◽  
First Time

The chemical constituents were isolated from the ethyl acetate fraction from ethanol extract of Selaginella doederleinii Hieron by column chromatography on silica gel and Sephadex LH-20. The chemical structures of six biflavones were elucidated on the basis of physicochemical properties and spectroscopic data as amentoflavone (1), robustaflavone 7,4',7''-o-trimethyl ether (2), heveaflavone (3), podocarpusflavone A (4), robustaflavone 4',4'''-o-dimethyl ether (5) and robustaflavone 4'-o-methyl ether (6). Biflavones 2, 4 and 5 were obtained from Selaginella doederleinii Hieron for the first time.

scholarly journals INITIAL RESEARCH ON CHEMICAL CONSTITUENTS OF CURCUMA SINGULARIS RHIZOMES

2018 ◽  
Vol 54 (2C) ◽  
pp. 402
Author(s):  
Nguyen Manh Cuong
Keyword(s):  
Benzoic Acid ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
2D Nmr ◽  
First Time ◽  
Initial Research

From the rhizomes of Curcuma singularis Gagnep (Zingiberaceae family), six compounds,including three terpenoids, p-menthane-1,2,4-triol (1), amoxantin A (2), rugosic acid B (3); twodiols, 2,3-butanediol (4) [2R,3R-butanediol (4a) and 2S,3S-butanediol (4b)], and meso-2,3-butanediol (5), along with 3-hydroxy-4-methoxy benzoic acid (6) were isolated. All of sixcompounds were obtained for the first time from the Curcuma genus. The structures of thosecompounds were determined by 1D and 2D-NMR spectroscopic data.

scholarly journals FLAVONOIDS ISOLATED FROM THE FLOWERS OF CAMELLIA CHRYSANTHA

2019 ◽  
Vol 57 (3) ◽  
pp. 287
Author(s):  
Hong Van Thi Nguyen ◽  
Bach Cao Pham ◽  
Inh Thi Cam ◽  
Phuong Lan Doan ◽  
Thanh Tat Le ◽  
...  
Keyword(s):  
Data Analysis ◽  
Methyl Ether ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Health Benefits ◽  
Small Tree ◽  
Evergreen Shrub ◽  
Chemical Structures ◽  
The Family ◽  
First Time

Camellia chrysantha (the golden camellia, golden tea) is a species of evergreen shrub or small tree belonging to the family Theaceae. The flowers and the leaves of this plant are used as tea and drank for its health benefits. The aim of this study was to investigate the chemical constituents of the flowers of Camellia chrysantha. Five flavonoids were isolated from the flowers of Camellia chrysantha (Theaceae), including (+)-catechin (1), (-)-epicatechin (2), quercetin (3), quercetin-3-O-methyl ether (4) and kaempferol (5). Their chemical structures were elucidated by spectroscopic data analysis and by comparison with those reported in the literature. Among five compounds, compounds 4 was isolated for the first time from this species.

Chemical Constituents of Ajuga parviflora

2000 ◽  
Vol 55 (1) ◽  
pp. 100-103 ◽  
Author(s):  
Hafiz Rub Nawaz ◽  
Abdul Malik ◽  
Pir Muhammad ◽  
Saeed Ahmed ◽  
Muhammad Riaz
Keyword(s):  
Spectroscopic Data ◽  
Pyrrolizidine Alkaloids ◽  
Methanolic Extract ◽  
Chemical Constituents ◽  
Two Dimensional ◽  
First Time

Two new antifungal withanolides, (1) and (2) have been isolated from the defatted methanolic extract of Ajuga parviflora. Their structures were established as 3β,17β,20-trihydroxy-1-oxo-(20R, 22R)-witha-5,14,24-trienolide (1), 28-hydroxy-14,20-epoxy-1-oxo-(22R)-witha-2,5,24-trienolide (2) on the basis of spectroscopic data including two dimensional NMR tech­niques. The pyrrolizidine alkaloids senecionine (3) and integerrimine (4) are also reported for the first time from A. parviflora

scholarly journals A New Ajmaline-type Alkaloid from the Roots of Rauvolfia serpentina

2017 ◽  
Vol 12 (4) ◽  
pp. 1934578X1701200
Author(s):  
Thitima Rukachaisirikul ◽  
Suwadee Chokchaisiri ◽  
Parichat Suebsakwong ◽  
Apichart Suksamrarn ◽  
Chainarong Tocharus
Keyword(s):  
Data Analysis ◽  
Spectroscopic Data ◽  
Anticholinesterase Activity ◽  
Rauvolfia Serpentina ◽  
Vasorelaxant Activity ◽  
First Time

A new ajmaline-type alkaloid, 21- O-methylisoajmaline (1), together with twenty-one known compounds, a mixture ofβ-sitosterol (2) and stigmasterol (3), reserpinine (4), tetrahydroalstonine (5), reserpine (6), venoterpine (7), yohimbine (8), 6'- O-(3,4,5-trimethoxybenzoyl)glomeratose A (9), isoajmaline (10), 3- epi-α-yohimbine (11), methyl 3,4,5-trimethoxy- trans-cinnamate (12), a mixture of β-sitosterol 3- O-β-D-glucopyranoside (13) and stigmasterol 3- O-β-D-glucopyranoside (14), rescidine (15), 7-deoxyloganic acid (16), ajmaline (17), suaveoline (18), (+)-tetraphyllicine (19), loganic acid (20), 3-hydroxysarpagine (21), and sarpagine (22), were isolated from the roots of Rauvolfia serpentina. Their structures were elucidated by spectroscopic data analysis and comparison with literature data. Compounds 11, 12 and 15 were for the first time identified from the genus Rauvolfia and 5, 7, 11, 12, 15, 18 and 22 were found from R. serpentina for the first time. Compound 11 showed moderate anticholinesterase activity with IC50 value of 15.58 μM, whereas 6 exhibited strong vasorelaxant activity with the EC50 value of 0.05 μM.

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