scholarly journals Polar Alkaloids from the Caribbean Marine Sponge Niphates Digitalis

2010 ◽  
Vol 5 (8) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Erik L. Regalado ◽  
Judith Mendiola ◽  
Abilio Laguna ◽  
Clara Nogueiras ◽  
Olivier P. Thomas
Keyword(s):  
Marine Sponge ◽  
Spectroscopic Data ◽  
Natural Source ◽  
Flash Chromatography ◽  
First Report ◽  
Data Analyses ◽  
Rp Hplc ◽  
The Caribbean

A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7-ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.

scholarly journals Chemical Constituents of Egyptian Withania Somnifera Leaves and Fruits and their Anticholinesterase Activity

2019 ◽  
Vol 63 (4) ◽  
Author(s):  
Rahma S. Mahrous ◽  
Hoda M. Fathy ◽  
RASHA M. ABU EL-KHAIR ◽  
ABDALLAH A. OMAR
Keyword(s):  
Spectroscopic Data ◽  
Withania Somnifera ◽  
Vaccenic Acid ◽  
Chemical Constituents ◽  
Light Petroleum ◽  
Natural Source ◽  
Petroleum Fraction ◽  
Anticholinesterase Activity ◽  
First Report ◽  
First Time

Seven compounds were isolated from the leaves and fruits of Egyptian Withania somnifera dunal, (Family: Solanaceae). The identity of the compounds based on their spectroscopic data were as follows: two withanolides; withaperuvin C (1), phyperunolideF (2) and four lipids;1,2-di-O-palmitoyl-3-O-(6´´´-sulfo-α-D-quinovopyranosyl)-glycerol (3), vaccenic acid (5), 1,3 dicaproyl,2-vaccenoyl-glycerol (6), vaccenolymonoglyceride (7) and β-sitosterol glucoside (4). All the isolated metabolites except (4) were reported for the first time from this plant. Besides, this is the first report for isolation of compounds (6, 7) in a pure form from a natural source. Different fractions of the fruits of the Egyptian plant were investigated for their anticholinesterase activities where the most potent ones found to be the aqueous, the light petroleum fraction in addition to a mixture of lipids.

5α, 8α-Epidioxysterol from the marine sponge Biemna Triraphis Topsent

2008 ◽  
Vol 3 (5) ◽  
pp. 1934578X0800300
Author(s):  
Julia Bensemhouna ◽  
Isabelle Bombardaa ◽  
Maurice Aknin ◽  
Jean Vacelet ◽  
Emile M. Gaydou
Keyword(s):  
Indian Ocean ◽  
Marine Sponge ◽  
West Coast ◽  
Spectroscopic Data ◽  
First Report

5α, 8α-Epidioxy-24( S)-ethylcholest-6-en-3β-ol (1) was isolated from the marine sponge Biemna triraphis Topsent collected at Andavadoaka, near Toliary (west coast of Madagascar-Indian Ocean). The structure was elucidated from NMR spectroscopic data. This is the first report of this compound in a marine sponge belonging to the Biemna genus.

scholarly journals Organic aerosols in the Caribbean trade winds: A natural source?

1997 ◽  
Vol 102 (D17) ◽  
pp. 21307-21313 ◽  
Author(s):  
T. Novakov ◽  
C. E. Corrigan ◽  
J. E. Penner ◽  
C. C. Chuang ◽  
O. Rosario ◽  
...  
Keyword(s):  
Organic Aerosols ◽  
Natural Source ◽  
Trade Winds ◽  
The Caribbean

Antidiabetic and Antioxidant Activities of Major Flavonoids of Cynanchum acutum L. (Asclepiadaceae) Growing in Egypt

2008 ◽  
Vol 63 (9-10) ◽  
pp. 658-662 ◽  
Author(s):  
Ghada A. Fawzy ◽  
Hossam M. Abdallah ◽  
Mohamed S. A. Marzouk ◽  
Fathy M. Soliman ◽  
Amany A. Sleem
Keyword(s):  
Blood Glucose ◽  
Spectroscopic Data ◽  
Methanolic Extract ◽  
Antioxidant Activities ◽  
First Report ◽  
Insulin Levels ◽  
Butanol Fraction ◽  
Aerial Parts ◽  
First Time

Seven flavonoids were isolated from the butanol fraction of the methanolic extract of the aerial parts of Cynanchum acutum L. (Asclepiadaceae). All of which have been isolated for the first time from the genus Cynanchum. Their structures were established as quercetin 3-O-β-galacturonopyranoside (1), quercetin 7-O-β-glucopyranoside (2), tamarixtin 3-O-β-galacturonopyranoside (3), kaempferol 3-O-β-galacturonopyranoside (4), 8-hydroxyquercetin 3-O-β-galactopyranoside (5), tamarixtin 3-O-α-rhamnopyranoside (6), and tamarixtin 7-O-α-arabinopyranoside (7) on the basis of their chromatographic properties, chemical and spectroscopic data. The major isolated flavonoids 1, 2 and 3 were found to exhibit significant antioxidant and antidiabetic activities (by measuring blood glucose and insulin levels). This is the first report about the antioxidant and antidiabetic activities of compounds 1 - 3.

scholarly journals Fusarisolins A–E, Polyketides from the Marine-Derived Fungus Fusarium solani H918

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 125 ◽  
Author(s):  
Siwen Niu ◽  
Xi-Xiang Tang ◽  
Zuowang Fan ◽  
Jin-Mei Xia ◽  
Chun-Lan Xie ◽  
...  
Keyword(s):  
Gene Expression ◽  
Antifungal Activity ◽  
Fusarium Solani ◽  
Spectroscopic Data ◽  
Coenzyme A ◽  
Pathogenic Fungus ◽  
Chemical Conversion ◽  
Inhibitory Effects ◽  
Data Analyses ◽  
Naturally Occurring

Five new (fusarisolins A–E, 1 to 5) and three known (6 to 8) polyketides were isolated from the marine-derived fungus Fusarium solani H918, along with six known phenolics (9 to 14). Their structures were established by comprehensive spectroscopic data analyses, methoxyphenylacetic acid (MPA) method, chemical conversion, and by comparison with data reported in the literature. Compounds 1 and 2 are the first two naturally occurring 21 carbons polyketides featuring a rare β- and γ-lactone unit, respectively. All isolates (1 to 14) were evaluated for their inhibitory effects against tea pathogenic fungus Pestalotiopsis theae and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase gene expression. Compound 8 showed potent antifungal activity with an ED50 value of 55 μM, while 1, 8, 13, and 14 significantly inhibited HMG-CoA synthase gene expression.

scholarly journals Saturated Ceramides from the Sponge Dysidea Robusta

2009 ◽  
Vol 4 (7) ◽  
pp. 1934578X0900400
Author(s):  
Suzi O. Marques ◽  
Katyuscya Veloso ◽  
Antonio G. Ferreira ◽  
Eduardo Hajdu ◽  
Solange Peixinho ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Crude Extract ◽  
Spectroscopic Data ◽  
Chemical Investigation ◽  
Ms Analysis

Chemical investigation of the crude extract of a marine sponge Dysidea robusta led to the isolation of an inseparable mixture of saturated ceramides. These were identified from spectroscopic data as well as by hydrolysis followed by LC-MS analysis of the sphingosine moieties.

scholarly journals Three New Spongian Diterpenes from the Fijian Marine Sponge Spongia sp

2009 ◽  
Vol 4 (3) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Harald Gross ◽  
Anthony D. Wright ◽  
Uwe Reinscheid ◽  
Gabriele M. König
Keyword(s):  
Molecular Modeling ◽  
Marine Sponge ◽  
Spectroscopic Data ◽  
Chemical Investigation ◽  
Complete Analysis ◽  
Quantum Mechanical ◽  
Quantum Mechanical Calculations ◽  
Fiji Islands ◽  
Combined Strategy ◽  
Spongian Diterpene

Chemical investigation of the marine sponge Spongia sp., collected from the Fiji Islands resulted in the isolation of three new furanoditerpenoids 1-3, along with the known compounds epispongiatriol (4) and 17,19-dihydroxyspongia-13(16),14-dien-2,3-dione (5) While 1 is a new spongian diterpene with a modified oxidation pattern, compounds 2 and 3 represent two new ring A-contracted spongians, displaying a novel and unprecedented nor-spongian carbon skeleton. Despite their labile nature the structures could be established through a combined strategy including complete analysis of spectroscopic data (NMR, MS), molecular modeling and quantum-mechanical calculations.

scholarly journals Two Ring-A-Aromatized Bile Acids from the Marine Sponge Sollasella Moretonensis

2010 ◽  
Vol 5 (10) ◽  
pp. 1934578X1000501 ◽  
Author(s):  
Zhenyu Lu ◽  
Ryan M. Van Wagoner ◽  
Mary Kay Harper ◽  
John N. A. Hooper ◽  
Chris M. Ireland
Keyword(s):  
Bile Acids ◽  
Marine Sponge ◽  
2D Nmr ◽  
Natural Source ◽  
Nmr Studies

Two ring-A-aromatized bile acids, 1 and 2, were isolated from the sponge Sollasella moretonensis, collected from the seabed of northern Queensland. Structures were assigned on the basis of extensive 1D and 2D NMR studies, as well as analysis by HRESIMS. Compound 2 has previously been produced synthetically, though this marks its first isolation from a natural source.

scholarly journals Pubinernoid A and Apo-9′-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp

2016 ◽  
Vol 11 (6) ◽  
pp. 1934578X1601100
Author(s):  
Hsin-Huan Chang ◽  
Yu-Chia Chang ◽  
Wu-Fu Chen ◽  
Tsong-Long Hwang ◽  
Lee-Shing Fang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Spectroscopic Data ◽  
Spectroscopic Analysis ◽  
Inhibitory Effect ◽  
Human Neutrophils ◽  
Gorgonian Coral ◽  
First Report ◽  
Significant Inhibitory Effect ◽  
Animal Source

The structures of pubinernoid A (1) and apo-9′-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9′-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 μM.

Sign in / Sign up

Export Citation Format

Share Document