Bioavailability Enhancement of Poorly Water Soluble and Weakly Acidic New Chemical Entity with 2-Hydroxy Propyl-β-Cyclodextrin: Selection of Meglumine, a Polyhydroxy Base, as a Novel Ternary Component

2006 ◽  
Vol 11 (4) ◽  
pp. 443-451 ◽  
Author(s):  
S. Basavaraj ◽  
Vaibhav Sihorkar ◽  
T.R. Shantha Kumar ◽  
Prakash Sundaramurthi ◽  
Nuggehally R. Srinivas ◽  
...  
Keyword(s):  
Chemical Entity ◽  
Water Soluble ◽  
Bioavailability Enhancement ◽  
Poorly Water Soluble ◽  
Ternary Component ◽  
New Chemical Entity ◽  
Selection Of

Clay-based Formulations for Bioavailability Enhancement of Poorly Water-soluble Drugs

2021 ◽  
Vol 22 ◽  
Author(s):  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
High Surface ◽  
High Surface Area ◽  
Delivery Systems ◽  
Water Soluble ◽  
Limited Information ◽  
Bioavailability Enhancement ◽  
Poorly Water Soluble Drugs ◽  
Ideal System ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

: Clays have been used in various health care products, including drug delivery systems. Advanced formulations have been investigated to take full advantage of clays or clay-based materials. The remarkable properties of clays, such as high adsorption, high surface area, and high ion exchange capacities, provide an ideal system for the delivery of poorly water-soluble drugs. There is currently limited information on the classification and discussion of clay-based formulations for poorly water-soluble drugs. This review aims to describe efficient delivery systems that use clay as the main excipient in formulations. More details about the strategies of using clays in formulations as well as fabrication methods will be discussed. Moreover, combinations with other excipients in hybrid formulations will also be mentioned in evaluating the efficacy of these systems. The highlighted recent studies on clay-based formulations for poorly water-soluble drugs could provide fundamental approaches and prospects to apply them in drug development.

Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs

2012 ◽  
Vol 9 (5) ◽  
pp. 585-598 ◽  
Author(s):  
Sabna Kotta ◽  
Abdul Wadood Khan ◽  
Kannissery Pramod ◽  
Shahid H Ansari ◽  
Rakesh Kumar Sharma ◽  
...  
Keyword(s):  
Water Soluble ◽  
Bioavailability Enhancement ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

scholarly journals An Overview on Recent Patents and Technologies on Solid Dispersion

2020 ◽  
Vol 14 (1) ◽  
pp. 63-74 ◽  
Author(s):  
Ritu Kaushik ◽  
Vikas Budhwar ◽  
Deepak Kaushik
Keyword(s):  
Solid Dispersion ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Formulation Development ◽  
Bioavailability Enhancement ◽  
Molecular Arrangement ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Cryogenic Processing

The oral bioavailability enhancement of poorly water-soluble medicaments is still one of the most complicated aspects of the formulation development. Various approaches are currently available for solubility and rate of dissolution enhancement such as salt formation, solubilization and reduction of particle size, each with its own limitations and advantages. Solid dispersion is one of the most suitable approaches for the formulation development of poorly water-soluble drugs. The popularity of solid dispersion is evident from the increasing number of patent applications and patents granted in this field during recent years. This article reviews the various approaches for the preparation of solid dispersion such as a solvent melting, hot-melt extrusion method, solvent evaporation method, cryogenic processing approaches etc. from the perspective of patents filed or granted for these techniques. Some of the aspects taken into account before the preparation of solid dispersions are carrier selection and physicchemical testing along with an insight into the molecular arrangement of medicaments in solid dispersion. The manuscript further highlights various commercial patented technology platforms such as Solumertm, Hovione and Kinetisol which are based on the concept of solid dispersions.

Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol–polysorbate 80 mixture

2004 ◽  
Vol 269 (1) ◽  
pp. 251-258 ◽  
Author(s):  
Hemant N Joshi ◽  
Ravindra W Tejwani ◽  
Martha Davidovich ◽  
Vaishali P Sahasrabudhe ◽  
Mohammed Jemal ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersion ◽  
Water Soluble ◽  
Polysorbate 80 ◽  
Bioavailability Enhancement ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug
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