Release kinetics of controlled release formulations of thiamethoxam employing nano-ranged amphiphilic PEG and diacid based block polymers in soil

Efficiency of kollicoat EMM 30 D and SR 30D as matrix forming material was investigated. It was found that, theophylline loaded granules prepared with these two polymers could not sustain drug release for a significant period of time. However, compression of these granules into tablets retarded drug release for up to 8 hours. Release was faster from EMM 30D polymeric system than that from SR 30D matrix. Effects of fillers and rate modifiers on drug liberation have been assessed. Incorporation of Avicel RC 591 and starch caused substantial release of theophylline from both the polymeric systems. Avicel PH 101 intensified the retardation effect of both EMM 30D and SR 30D on theophylline release. HPMC 50 cps, when added to the matrix, caused the release of theophylline to follow near zero order pattern. Increasing the content of HPMC in both EMM 30D and SR 30D compressed tablets decreased the rate and extent of theophylline release. In the presence of excipients, no significant differences between rate and extent of drug release from EMM 30D and SR 30D systems were found. Biexponential equation was applied to explore and explain drug release kinetics. It was found that drug release followed Fickian or case I kinetics from EMM 30D compressed tablet while anomalous or non-fickian kinetics of drug release was observed for SR 30D system. Key words: Kolliocoat SR 30D, Kollicoat EMM 30D, Theophylline, Matrix system, Controlled release Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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Mathematical Modeling of Controlled-Release Kinetics of Herbicides in a Dynamic-Water-Bath System

Applied Biochemistry and Biotechnology ◽

10.1385/abab:91-93:1-9:563 ◽

2001 ◽

Vol 91-93 (1-9) ◽

pp. 563-574 ◽

Cited By ~ 2

Author(s):

Félix M. Pereira ◽

Adilson R. Gonçalves ◽

André Ferraz ◽

Flávio T. Silva ◽

Samuel C. Oliveira

Keyword(s):

Mathematical Modeling ◽

Controlled Release ◽

Release Kinetics ◽

Water Bath ◽

Kinetics Of

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Synthesis and controlled release kinetics of pH-sensitive hollow polyaniline microspheres encapsuled with the corrosion inhibitor

Journal of Molecular Liquids ◽

10.1016/j.molliq.2021.117497 ◽

2021 ◽

pp. 117497

Author(s):

Yang Cao ◽

Xuwen Yuan ◽

Xuan Wang ◽

Wentao Li ◽

Huaiyu Yang

Keyword(s):

Controlled Release ◽

Corrosion Inhibitor ◽

Release Kinetics ◽

Ph Sensitive ◽

Kinetics Of

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Ordered mesoporous silicates as matrices for controlled release of drugs

Acta Pharmaceutica ◽

10.2478/v1007-010-0037-4 ◽

2010 ◽

Vol 60 (4) ◽

pp. 373-385 ◽

Cited By ~ 37

Author(s):

Tina Ukmar ◽

Odon Planinšek

Keyword(s):

Controlled Release ◽

Uv Light ◽

Release Kinetics ◽

Stimuli Responsive ◽

Mesoporous Silicates ◽

Ordered Mesoporous ◽

Poorly Soluble ◽

Model Drug ◽

Kinetics Of

Ordered mesoporous silicates as matrices for controlled release of drugs Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established in vitro.

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