Release Kinetics of a Controlled-Release Multiparticulate Dosage Form Prepared Using a Hot-Melt Fluid Bed Coating Method

Efficiency of kollicoat EMM 30 D and SR 30D as matrix forming material was investigated. It was found that, theophylline loaded granules prepared with these two polymers could not sustain drug release for a significant period of time. However, compression of these granules into tablets retarded drug release for up to 8 hours. Release was faster from EMM 30D polymeric system than that from SR 30D matrix. Effects of fillers and rate modifiers on drug liberation have been assessed. Incorporation of Avicel RC 591 and starch caused substantial release of theophylline from both the polymeric systems. Avicel PH 101 intensified the retardation effect of both EMM 30D and SR 30D on theophylline release. HPMC 50 cps, when added to the matrix, caused the release of theophylline to follow near zero order pattern. Increasing the content of HPMC in both EMM 30D and SR 30D compressed tablets decreased the rate and extent of theophylline release. In the presence of excipients, no significant differences between rate and extent of drug release from EMM 30D and SR 30D systems were found. Biexponential equation was applied to explore and explain drug release kinetics. It was found that drug release followed Fickian or case I kinetics from EMM 30D compressed tablet while anomalous or non-fickian kinetics of drug release was observed for SR 30D system. Key words: Kolliocoat SR 30D, Kollicoat EMM 30D, Theophylline, Matrix system, Controlled release Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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Characterization and mapping of the multi-component release kinetics of a Traditional Chinese Medicine dosage form using a modified LC/MS/MS method and chemomic release kinetic theory

Acta Pharmaceutica Sinica B ◽

10.1016/j.apsb.2011.06.007 ◽

2011 ◽

Vol 1 (2) ◽

pp. 106-114 ◽

Cited By ~ 3

Author(s):

Hai-yan Li ◽

Xiang-yong Cui ◽

Feng Gao ◽

Peter York ◽

Qun Shao ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Kinetic Theory ◽

Dosage Form ◽

Release Kinetics ◽

Release Kinetic ◽

Kinetics Of

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Mathematical Modeling of Controlled-Release Kinetics of Herbicides in a Dynamic-Water-Bath System

Applied Biochemistry and Biotechnology ◽

10.1385/abab:91-93:1-9:563 ◽

2001 ◽

Vol 91-93 (1-9) ◽

pp. 563-574 ◽

Cited By ~ 2

Author(s):

Félix M. Pereira ◽

Adilson R. Gonçalves ◽

André Ferraz ◽

Flávio T. Silva ◽

Samuel C. Oliveira

Keyword(s):

Mathematical Modeling ◽

Controlled Release ◽

Release Kinetics ◽

Water Bath ◽

Kinetics Of

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Synthesis and controlled release kinetics of pH-sensitive hollow polyaniline microspheres encapsuled with the corrosion inhibitor

Journal of Molecular Liquids ◽

10.1016/j.molliq.2021.117497 ◽

2021 ◽

pp. 117497

Author(s):

Yang Cao ◽

Xuwen Yuan ◽

Xuan Wang ◽

Wentao Li ◽

Huaiyu Yang

Keyword(s):

Controlled Release ◽

Corrosion Inhibitor ◽

Release Kinetics ◽

Ph Sensitive ◽

Kinetics Of

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Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling

Pharmaceutics ◽

10.3390/pharmaceutics12010077 ◽

2020 ◽

Vol 12 (1) ◽

pp. 77 ◽

Cited By ~ 10

Author(s):

Bhupendra Giri ◽

Eon Song ◽

Jaewook Kwon ◽

Ju-Hyun Lee ◽

Jun-Bom Park ◽

...

Keyword(s):

Controlled Release ◽

Drug Release ◽

Shell Thickness ◽

Fused Deposition Modeling ◽

Release Kinetics ◽

Hot Melt Extrusion ◽

Fickian Diffusion ◽

Melt Extrusion ◽

Fused Deposition ◽

Hot Melt

This work presents a novel approach for producing gastro-retentive floating tablets (GRFT) by coupling hot-melt extrusion (HME) and fused deposition three-dimensional printing (3DP). Filaments containing theophylline (THEO) within a hydroxypropyl cellulose (HPC) matrix were prepared using HME. 3DP tablets with different infill percentages and shell thickness were developed and evaluated to determine their drug content, floating behavior, dissolution, and physicochemical properties. The dissolution studies revealed a relationship between the infill percentage/shell thickness and the drug release behavior of the 3DP tablets. All the developed GRFTs possessed the ability to float for 10 h and exhibited zero-order release kinetics. The drug release could be described by the Peppas–Sahlin model, as a combination of Fickian diffusion and swelling mechanism. Drug crystallinity was found unaltered throughout the process. 3DP coupled with HME, could be an effective blueprint to produce controlled-release GRFTs, providing the advantage of simplicity and versatility compared to the conventional methods.

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