Association between the risk of coronary artery disease in South Asians and a deletion polymorphism in glutathioneS-transferase M1

Biomarkers ◽  
2003 ◽  
Vol 8 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Michael H. Wilson ◽  
Peter J. Grant ◽  
Kirti Kain ◽  
Darren P. Warner ◽  
Christopher P. wild
2011 ◽  
Vol 162 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Kevin R. Bainey ◽  
Colleen M. Norris ◽  
Milan Gupta ◽  
Danielle Southern ◽  
Diane Galbraith ◽  
...  

2006 ◽  
Vol 14 (2) ◽  
pp. 74-80 ◽  
Author(s):  
Updesh Singh Bedi ◽  
Sarabjeet Singh ◽  
Asmir Syed ◽  
Hamed Aryafar ◽  
Rohit Arora

ESC CardioMed ◽  
2018 ◽  
pp. 2887-2892
Author(s):  
Nizal Sarrafzadegan ◽  
Farzad Masoudkabir

Significant variation is evident among different ethnicities regarding the prevalence, awareness, severity, treatment, and complications of major cardiovascular disease (CVD) risk factors. Relative to white Europeans, stroke mortality is almost doubled in South Asians and Afro-Caribbeans; however, when coronary artery disease mortality is considered, it is high in South Asians and low in Afro-Caribbeans. Hypertension is more common, severe, and is associated with higher rates of morbidity and mortality in black people than white people. Diabetes is more prevalent and less controlled in South Asians which leads to a nearly fourfold higher cardiovascular mortality in South Asians than other ethnic groups. Furthermore, South Asians suffer from a highly atherogenic lipid profile. In contrast, black people are generally known for their higher high-density lipoprotein and lower triglyceride levels than white people which seem to play a major role in protecting them from coronary artery disease. For a given waist circumference, Asian, black, and Caucasian people show different levels of intra-abdominal adiposity and CVD risk. Hence, the joint definition from five major organizations in 2009 of the metabolic syndrome set ethnic-specific values of waist circumference to define central obesity. Black Caribbean men have the highest rates of current smoking among all ethnic groups in the United Kingdom while nearly all South Asian and black African women are never-smokers. Varied genetic and lifestyle-related risk factors and their interactions seem to be responsible for the ethnic differences in CVD risk factors. There is a clear need for ethnic-specific guidelines for diagnosis and treatment of major CVD risk factors to maximize the outcomes of preventive strategies.


2020 ◽  
Vol 76 (6) ◽  
pp. 703-714 ◽  
Author(s):  
Minxian Wang ◽  
Ramesh Menon ◽  
Sanghamitra Mishra ◽  
Aniruddh P. Patel ◽  
Mark Chaffin ◽  
...  

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Powell O Jose ◽  
Kristin M Azar ◽  
Jennifer Kang ◽  
Marshall Baek ◽  
Latha P Palaniappan ◽  
...  

Background: Health coaching programs, delivered by trained non-medical and medical personnel, and focused on diet and lifestyle counseling, have proven beneficial in both primary and secondary prevention of cardiovascular disease. These coaching programs, however, have not been tested or validated in South Asians, who have unique dietary and lifestyle habits, and greatly increased risk of coronary artery disease. Methods: We examined lipid values in participants who were invited to enroll in the Heart Health Coaching Program at the South Asian Heart Center at El Camino Hospital in Mountain View, California. Trained volunteer coaches contacted interested participants throughout the year by phone and email to deliver culturally-competent health education on diet, physical activity, and stress reduction. Participants were categorized, based on their level of participation, into three groups: those who did not enroll in the coaching program (non-coached, N=33), those who received some coaching (partially coached, N=145), and those who completed one full year of the program (fully coached, N=558). Fasting lipid measurements were obtained with mean differences being calculated from their baseline and last available follow-up lab test. Paired t-test was used for comparison of baseline and follow-up lab tests within each group. Multivariate age-adjusted analyses incorporated MANOVA to detect for differences between groups. Results: There were no significant differences in mean age(43, 42 and 43), mean BMI(25.8, 26.5 and 26.2), or baseline lipid values across the three groups (fully-coached, partially coached, and non-coached respectively). There were significant improvements in total cholesterol(TC) (-5.5±28.4mg/dl), LDL(-4.1±24.3), HDL (1.9±6.4), triglycerides(-16.1±67.3), and TC/HDL ratio(-0.31±0.83) in the fully coached group (p<0.001 for all). The partially coached group demonstrated reductions in total cholesterol(-5.2±27.8, p=0.03), LDL(-8.1±28.0mg/dl, p<0.001), and TC/HDL ratio (-0.42±1.01, p<0.001) with a trend towards increased HDL (4.9±31.3, p=0.06). Non-coached participants did not have any statistically significant differences for any lipid measurement. Coached participants were more likely to improve lipid values than partially coached and non-coached participants (p<0.001). Conclusions: Our results suggest the benefit of a volunteer culturally-competent coaching program for South Asians in improving their lipid profile. Benefit was obtained even for partially coached participants. Non-medically trained health coaches may be an effective method to deliver culturally appropriate cardiovascular health messages for South Asians at risk for developing coronary artery disease.


2002 ◽  
Vol 20 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Oliviero Olivieri ◽  
Silvia Grazioli ◽  
Francesca Pizzolo ◽  
Chiara Stranieri ◽  
Elisabetta Trabetti ◽  
...  

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