Prevalence and clinical association with calcinosis cutis in early systemic sclerosis

2021 ◽  
pp. 1-11
Author(s):  
Chawiporn Muktabhant ◽  
Punthip Thammaroj ◽  
Prathana Chowchuen ◽  
Chingching Foocharoen
Keyword(s):  
Systemic Sclerosis ◽  
Calcinosis Cutis ◽  
Early Systemic Sclerosis

Tocilizumab Prevents Progression of Early Systemic Sclerosis Associated Interstitial Lung Disease

2021 ◽  
Author(s):  
David Roofeh ◽  
Celia J F Lin ◽  
Jonathan Goldin ◽  
Grace Hyun Kim ◽  
Daniel E Furst ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Early Systemic Sclerosis

scholarly journals Early systemic sclerosis: assessment of clinical and pre-clinical organ involvement in patients with different disease features

Rheumatology ◽  
2010 ◽  
Vol 50 (2) ◽  
pp. 317-323 ◽  
Author(s):  
G. Valentini ◽  
G. Cuomo ◽  
G. Abignano ◽  
A. Petrillo ◽  
S. Vettori ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Organ Involvement ◽  
Early Systemic Sclerosis

Limited cutaneous systemic sclerosis: Total rehabilitation with fixed prosthesis on dental implants

2021 ◽  
pp. 239719832110043
Author(s):  
Miguel Angel Garcés Villalá ◽  
Carolina Zorrilla Albert
Keyword(s):  
Systemic Sclerosis ◽  
Bone Loss ◽  
Dental Implants ◽  
Social Life ◽  
Connective Tissue Diseases ◽  
The Body ◽  
Calcinosis Cutis ◽  
Complex Disorders ◽  
Standardized Parameters

Introduction: Limited cutaneous systemic sclerosis with special manifestations (calcinosis cutis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) is part of the group of connective tissue diseases, these rare autoimmune systemic pathologies cause thickening and hardening of tissues in different parts of the body and can lead to complex disorders. Oral manifestations of systemic sclerosis may include limited ability to open the mouth, xerostomia, periodontal disease, enlarged periodontal ligament, and bone resorption of the jaw. Case Description: A 54-year-old Caucasian patient presented with oral pain, swallowing, phonation and chewing difficulties associated with dental instability, hygiene/handling difficulties and her main problem with microstomia, which prevented her from removing the skeletal prosthesis for 4 years, depriving her of social life. Gradual treatment with dental implants was diagnosed and planned to support a fixed total denture adapted to the ridge with self-cleaning characteristics. After implant insertion, panoramic radiographs with standardized parameters were taken to compare crestal bone levels at the time of prosthesis placement and with 10 years of follow-up. Conclusion: The average crestal bone loss of the 12 implants after the 10 years of follow-up was 1.26 mm for the maxilla and 1.17 mm for the mandible. The survival of the 12 support implants of two total fixed prostheses in a clinical/radiographic follow-up of 10 years was 100%. After 10 years of follow-up, the 12 implants inserted had a bone loss similar to that of healthy patients and no pathologies were registered, recovering function, aesthetics, and self-esteem. This therapy must be implemented before the interincisal distance decreases to 30 mm to allow intraoral surgical/prosthetic access. Implant-supported total fixed rehabilitation is a viable, predictable, and recommended therapy in patients with limited cutaneous systemic sclerosis.

FRI0249 Pulmonary arterial hypertension in very early systemic sclerosis:

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 398.2-398
Author(s):  
J. Sanchez ◽  
S. Jordan ◽  
J. Distler ◽  
B. Maurer ◽  
D. Huscher ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pulmonary Arterial ◽  
Early Systemic Sclerosis

scholarly journals New Autoantibody Specificities in Systemic Sclerosis and Very Early Systemic Sclerosis

Antibodies ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 12
Author(s):  
Roberto Lande ◽  
Raffaella Palazzo ◽  
Anna Mennella ◽  
Immacolata Pietraforte ◽  
Marius Cadar ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Early Diagnosis ◽  
Antibody Response ◽  
Allelic Variant ◽  
The Other ◽  
Autoantibody Response ◽  
Autoimmune Condition ◽  
Early Systemic Sclerosis ◽  
Systemic Sclerosis Patient

Chemokine (C-X-C motif) ligand 4 (CXCL4) is a biomarker of unfavorable prognosis in Systemic Sclerosis (SSc), a potentially severe autoimmune condition, characterized by vasculitis, fibrosis and interferon (IFN)-I-signature. We recently reported that autoantibodies to CXCL4 circulate in SSc patients and correlate with IFN-α. Here, we used shorter versions of CXCL4 and CXCL4-L1, the CXCL4 non-allelic variant, to search for autoantibodies exclusively reacting to one or the other CXCL4 form. Moreover, to address whether anti-CXCL4/CXCL4-L1 antibodies were present before SSc onset and predicted SSc-progression, we longitudinally studied two VEDOSS (Very Early Diagnosis of Systemic Sclerosis) patient cohorts, separating SSc-progressors from SSc-non-progressors. We found that anti-CXCL4-specific autoantibodies were present in both SSc and VEDOSS patients (both SSc-progressors and SSc-non-progressors). Anti-CXCL4-L1-specific autoantibodies were especially detected in long-standing SSc (lsSSc). Anti-CXCL4/CXCL4-L1 antibodies correlated with IFN-α and with specific SSc-skin features but only in lsSSc and not in early SSc (eaSSc) or VEDOSS. Thus, a broader antibody response, with reactivity spreading to CXCL4-L1, is characteristic of lsSSc. The early anti-CXCL4 autoantibody response seems qualitatively different from, and likely less pathogenic than, that observed in advanced SSc. Lastly, we confirm that anti-CXCL4 autoantibodies are SSc-biomarkers and uncover that also CXCL4-L1 becomes an autoantigen in lsSSc.

scholarly journals Early systemic sclerosis: short-term disease evolution and factors predicting the development of new manifestations of organ involvement

2012 ◽  
Vol 14 (4) ◽  
pp. R188 ◽  
Author(s):  
Gabriele Valentini ◽  
Serena Vettori ◽  
Giovanna Cuomo ◽  
Michele Iudici ◽  
Virginia D'Abrosca ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Organ Involvement ◽  
Short Term ◽  
Disease Evolution ◽  
Early Systemic Sclerosis

Classification of Japanese patients with mild/early systemic sclerosis (SSc) by the 2013 ACR/EULAR classification criteria for SSc

2016 ◽  
Vol 27 (4) ◽  
pp. 614-617 ◽  
Author(s):  
Yuka Ikawa ◽  
Yasuhito Hamaguchi ◽  
Naoki Mugii ◽  
Takashi Matsushita ◽  
Kazuhiko Takehara
Keyword(s):  
Systemic Sclerosis ◽  
Japanese Patients ◽  
Classification Criteria ◽  
Early Systemic Sclerosis

scholarly journals Knee myopericytoma-case report and literature review

2020 ◽  
Vol 12 (6) ◽  
pp. 127-128
Author(s):  
Susana Rodrigues ◽  
Catrine Ferreira ◽  
Tiago Coelho ◽  
Diogo Gaspar ◽  
Jean Fallah ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Systemic Sclerosis ◽  
Middle Age ◽  
Subcutaneous Tissue ◽  
Connective Tissue Diseases ◽  
Systemic Lupus Erythematous ◽  
Systemic Lupus ◽  
Calcinosis Cutis ◽  
Substantial Morbidity

Calcinosis cutis is a rare disorder characterized by of deposition of insoluble calcium salts in the skin and subcutaneous tissue. Five subtypes of calcinosis cutis are described: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis.1 Of these subtypes, dystrophic calcinosis (DC) is the most common, and it is the most frequently seen in association with underlying autoimmune connective tissue diseases.2 Dermatomyositis, systemic sclerosis and less commonly systemic lupus erythematous were described to be complicated by DC. However, DC associated with rheumatoid arthritis (RA) is extremely rare.2 The condition causes substantial morbidity and is associated with pain and limitation of movement when the process involves areas close to joints or when ulceration occurs.2 We report a middle age Sudanese woman with good controlled RA who developed dystrophic calcinosis cutis.

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