Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells

Yan Zhang; Qin Wang; Luolan Li; Yi Le; Li Liu; Jing Yang; Yongliang Li; Guochen Bao; Longjia Yan

doi:10.1080/14756366.2021.1933466

Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/14756366.2021.1933466 ◽

2021 ◽

Vol 36 (1) ◽

pp. 1205-1216

Author(s):

Yan Zhang ◽

Qin Wang ◽

Luolan Li ◽

Yi Le ◽

Li Liu ◽

...

Keyword(s):

Structure Activity Relationship ◽

Tumour Cells ◽

Egfr Inhibitors ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study ◽

Antiproliferative Activities

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Synthesis and Structure-Activity Relationship Study of 2-Substituted- 5-(5-nitro-2-thienyl)-1,3,4-thiadiazoles as Anti-Helicobacter pylori Agents

Letters in Drug Design & Discovery ◽

10.2174/157018009789057599 ◽

2009 ◽

Vol 6 (6) ◽

pp. 468-474 ◽

Cited By ~ 1

Author(s):

Alireza Foroumadi ◽

Somayeh Sedaghat ◽

Saeed Emami ◽

Maryam Yazdanian ◽

Mohammad Moshafi ◽

...

Keyword(s):

Helicobacter Pylori ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

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Structure-activity relationship study on the bioreduction of AZO dyes byClostridium paraputrificum

Environmental Toxicology and Chemistry ◽

10.1002/etc.5620200304 ◽

2001 ◽

Vol 20 (3) ◽

pp. 479-484

Author(s):

David Moir ◽

Sheila Masson ◽

Ih Chu

Keyword(s):

Azo Dyes ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

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Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113291 ◽

2021 ◽

pp. 113291

Author(s):

Peng Li ◽

Ying Liu ◽

Hua Yang ◽

Hong-Min Liu

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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Structure–Activity Relationship Study and Biological Evaluation of 2-(Disubstituted phenyl)-indole-5-propanoic Acid Derivatives as GPR40 Full Agonists

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00031 ◽

2021 ◽

Vol 64 (7) ◽

pp. 4130-4149

Author(s):

Xiaodi Zhao ◽

Dong-Oh Yoon ◽

Jaeho Yoo ◽

Hyun-Ju Park

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Propanoic Acid ◽

Structure Activity ◽

Relationship Study

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Strategic structure-activity relationship study on a follistatin-derived myostatin inhibitory peptide

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2021.128163 ◽

2021 ◽

pp. 128163

Author(s):

Mariko Saitoh ◽

Kentaro Takayama ◽

Yoshimi Roppongi ◽

Takahiro Shimada ◽

Akihiro Taguchi ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Inhibitory Peptide ◽

Structure Activity ◽

Relationship Study

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Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.03.081 ◽

2017 ◽

Vol 134 ◽

pp. 86-96 ◽

Cited By ~ 3

Author(s):

Anna Y. Belorusova ◽

Andrea Martínez ◽

Zoila Gándara ◽

Generosa Gómez ◽

Yagamare Fall ◽

...

Keyword(s):

Vitamin D ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Side Chain ◽

Vitamin D Analogs ◽

Structure Activity ◽

Relationship Study

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Structure–activity relationship study at the 3′-N-position of paclitaxel: synthesis and biological evaluation of 3′-N-acyl-paclitaxel analogues

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(02)00218-3 ◽

2002 ◽

Vol 10 (10) ◽

pp. 3145-3151 ◽

Cited By ~ 17

Author(s):

E Roh

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study ◽

Synthesis And Biological Evaluation

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Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease

Bioorganic Chemistry ◽

10.1016/j.bioorg.2018.01.017 ◽

2018 ◽

Vol 77 ◽

pp. 223-235 ◽

Cited By ~ 18

Author(s):

Aida Iraji ◽

Omidreza Firuzi ◽

Mehdi Khoshneviszadeh ◽

Hamid Nadri ◽

Najmeh Edraki ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Triazine Derivatives ◽

Relationship Study

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Design, Synthesis and Quantitative Structure-Activity Relationship Study of N-(3-Oxo-3,4-dihydro-2H-benzo(1,4)oxazine-7-carbonyl)guanidine Derivatives as Potent Na/H Exchange Inhibitors.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.45.1975 ◽

1997 ◽

Vol 45 (12) ◽

pp. 1975-1983 ◽

Cited By ~ 3

Author(s):

Takeshi YAMAMOTO ◽

Manabu HORI ◽

Ikuo WATANABE ◽

Hisayoshi TSUTSUI ◽

Kengo HARADA ◽

...

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Guanidine Derivatives ◽

Structure Activity ◽

Relationship Study

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Agropyrenol, a Phytotoxic Fungal Metabolite, and Its Derivatives: A Structure–Activity Relationship Study

Journal of Agricultural and Food Chemistry ◽

10.1021/jf304933z ◽

2013 ◽

Vol 61 (8) ◽

pp. 1779-1783 ◽

Cited By ~ 19

Author(s):

Alessio Cimmino ◽

Maria Chiara Zonno ◽

Anna Andolfi ◽

Ciro Troise ◽

Andrea Motta ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Fungal Metabolite ◽

Structure Activity ◽

Relationship Study

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