Objective: to analyze changes in the level of lactate dehydrogenase (LDH) as an early marker of degree of central nervous system lesions in newborns with hypoxic-ischemic encephalopathy (HIE).Materials and methods. 38 infants with HIE moderate (grade II) and severe (grade III) according to the criteria described by Sarnat (in the period ≤72 hours after delivery) undergoing treatment in the neonatal intensive care unit at Zaporizhzhia Regional State Children’s Hospital were examined. Patients were randomly assigned to the groups. The average gestation age was 38.70 ± 1.56 weeks, and the average postconceptional age was 1.10 ± 0.46 days.Group 1 consisted of patients with moderate (grade II) HIE (n = 30), group 2 consisted of patients with severe (grade III) HIE (n = 8).Patients in both groups received traditional mechanical ventilation.On the 3rd and 7th day of life, the concentration of serum LDH in both groups was determined. A comparative analysis of serum LDH level was carried out and the diagnostic value of determining the LDH level as an early marker of CNS damage in newborns with HIE was analyzed.Results and discussion. Analysis of the LDH content in blood serum indicates that in both groups a significant increased of LDH level is observed on the 3rd day of life. In group 1, this indicator was 1151.6 ± 123.1 U / l, in group 2 - 3568.4 ± 212.4 U / l at p <0.01.On the 7th day of life, newborns of the 1st group had significant lower value of LDH (611.7 ± 86.1 U / L) compared with the 2nd group - 4946.4 ± 263.4 U / L, p <0.0003.There is a clear tendency of decreasing LDH on the 7th day of life in babies with moderate HIE - 611.7 ± 86.1 U / l at p <0.01. In newborns with severe HIE, level of LDH on day 7 compared to 3 does significantly not decrease.
VARIABILITY OF SERUM LACTATE DEHYDROGENASE IN FULL – TERM INFANTS WITH MODERATE AND SEVERE HYPOXIC-ISCHEMIC ENCEPHALOPATHY
