G209(P) Salivary lactate dehydrogenase for early diagnosis of hypoxic-ischemic encephalopathy in neonates

2019 ◽  
Author(s):  
A Mehta ◽  
B Malik ◽  
D Chawla
Keyword(s):  
Lactate Dehydrogenase ◽  
Early Diagnosis ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

scholarly journals VARIABILITY OF SERUM LACTATE DEHYDROGENASE IN FULL – TERM INFANTS WITH MODERATE AND SEVERE HYPOXIC-ISCHEMIC ENCEPHALOPATHY

2020 ◽  
pp. 28-32
Author(s):  
О. Ю. Клєвакіна ◽  
І. О. Анікін
Keyword(s):  
Lactate Dehydrogenase ◽  
Hypoxic Ischemic Encephalopathy ◽  
Serum Lactate Dehydrogenase ◽  
Term Infants ◽  
Early Marker ◽  
Grade Ii ◽  
Group 2 ◽  
Ischemic Encephalopathy ◽  
Grade Iii ◽  
Severe Grade

Objective: to analyze changes in the level of lactate dehydrogenase (LDH) as an early marker of degree of central nervous system lesions in newborns with hypoxic-ischemic encephalopathy (HIE).Materials and methods. 38 infants with HIE moderate (grade II) and severe (grade III) according to the criteria described by Sarnat (in the period ≤72 hours after delivery) undergoing treatment in the neonatal intensive care unit at Zaporizhzhia Regional State Children’s Hospital were examined. Patients were randomly assigned to the groups. The average gestation age was 38.70 ± 1.56 weeks, and the average postconceptional age was 1.10 ± 0.46 days.Group 1 consisted of patients with moderate (grade II) HIE (n = 30), group 2 consisted of patients with severe (grade III) HIE (n = 8).Patients in both groups received traditional mechanical ventilation.On the 3rd and 7th day of life, the concentration of serum LDH in both groups was determined. A comparative analysis of serum LDH level was carried out and the diagnostic value of determining the LDH level as an early marker of CNS damage in newborns with HIE was analyzed.Results and discussion. Analysis of the LDH content in blood serum indicates that in both groups a significant increased of LDH level is observed on the 3rd day of life. In group 1, this indicator was 1151.6 ± 123.1 U / l, in group 2 - 3568.4 ± 212.4 U / l at p <0.01.On the 7th day of life, newborns of the 1st group had significant lower value of LDH (611.7 ± 86.1 U / L) compared with the 2nd group - 4946.4 ± 263.4 U / L, p <0.0003.There is a clear tendency of decreasing LDH on the 7th day of life in babies with moderate HIE - 611.7 ± 86.1 U / l at p <0.01. In newborns with severe HIE, level of LDH on day 7 compared to 3 does significantly not decrease.

scholarly journals The Use of Fuzzy BackPropagation Neural Networks for the Early Diagnosis of Hypoxic Ischemic Encephalopathy in Newborns

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Liu Li ◽  
Huo Liqing ◽  
Lu Hongru ◽  
Zhang Feng ◽  
Zheng Chongxun ◽  
...  
Keyword(s):  
Neural Networks ◽  
Artificial Neural Networks ◽  
Early Diagnosis ◽  
Recognition Rate ◽  
Hypoxic Ischemic Encephalopathy ◽  
Correct Recognition ◽  
Backpropagation Neural Networks ◽  
Artificial Neural ◽  
Correct Recognition Rate ◽  
Ischemic Encephalopathy

Objective. To establish an early diagnostic system for hypoxic ischemic encephalopathy (HIE) in newborns based on artificial neural networks and to determine its feasibility.Methods. Based on published research as well as preliminary studies in our laboratory, multiple noninvasive indicators with high sensitivity and specificity were selected for the early diagnosis of HIE and employed in the present study, which incorporates fuzzy logic with artificial neural networks.Results. The analysis of the diagnostic results from the fuzzy neural network experiments with 140 cases of HIE showed a correct recognition rate of 100% in all training samples and a correct recognition rate of 95% in all the test samples, indicating a misdiagnosis rate of 5%.Conclusion. A preliminary model using fuzzy backpropagation neural networks based on a composite index of clinical indicators was established and its accuracy for the early diagnosis of HIE was validated. Therefore, this method provides a convenient tool for the early clinical diagnosis of HIE.

Lactate Dehydrogenase, Aspartate Aminotransferase, and Alanine Aminotransferase Cord Serum Levels as Early Markers of Hypoxic–Ischemic Encephalopathy in Babies with Severe Perinatal Asphyxia

2018 ◽  
Vol 17 (03) ◽  
pp. 105-110
Author(s):  
Tolulope Ogundele ◽  
Saheed Babajide A. Oseni ◽  
Joshua A. Owa ◽  
Olorunfemi Ogundele
Keyword(s):  
Lactate Dehydrogenase ◽  
Apgar Score ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Perinatal Asphyxia ◽  
Serum Levels ◽  
Hypoxic Ischemic Encephalopathy ◽  
Apgar Scores ◽  
Cord Serum ◽  
Ischemic Encephalopathy

AbstractPerinatal asphyxia is a major cause of morbidity and mortality among newborn babies. Severe perinatal asphyxia can be associated with multiple organ dysfunctions resulting in the release of a variety of intracellular enzymes. A major concern is how to identify newborns in need of prompt and aggressive management to minimize the risk of early severe neurological sequelae such as hypoxic–ischemic encephalopathy. The present study was performed to determine the relationship between cord serum levels of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and severity of perinatal asphyxia among Nigerian newborn babies. This was a prospective, comparative case–control study at the Obafemi Awolowo University Teaching Hospital, Ile-Ife. Cord blood was collected at delivery for serum levels of lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase. Each baby was evaluated for the severity of perinatal asphyxia at 1 minute of life using Apgar scores. Apgar score less than 7 at 1 minute was regarded as perinatal asphyxia. The Apgar scores were related to cord serum levels of the enzymes. The data were analyzed using Statistical Package for the Social Sciences for Windows, version 17.0. One hundred and forty babies, comprising 70 babies with and 70 babies without perinatal asphyxia were studied. Thirty-six (51.4%) of the neonates had severe perinatal asphyxia with Apgar score of 3 and below; 15 (41.7%) of the 36 had hypoxic–ischemic encephalopathy. The mean of values of each of the three enzymes was statistically significantly higher in babies with perinatal asphyxia compared with controls (p < 0.001 for each enzyme) and in babies with hypoxic–ischemic encephalopathy than in babies with severe perinatal asphyxia but without hypoxic–ischemic encephalopathy (p < 0.001). A very high proportion of babies with severe perinatal asphyxia developed hypoxic–ischemic encephalopathy. Based on the cord serum enzyme levels, almost all the babies who had hypoxic–ischemic encephalopathy would have been identified at delivery. Routine estimation of the cord serum levels of these enzymes among babies with severe perinatal may be used to identify babies who may develop acute serious neurological complications for anticipatory management.

scholarly journals Salivary Lactate Dehydrogenase in Relationship to the Severity of Hypoxic-Ischemic Encephalopathy among Newborn Infants

Scientifica ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hend Elmoursi ◽  
Mohamed Abdalla ◽  
Bader Eldin Mesbah ◽  
Abdelmoneim Khashana
Keyword(s):  
Lactate Dehydrogenase ◽  
Perinatal Asphyxia ◽  
Neurological Complication ◽  
Newborn Infants ◽  
Positive Association ◽  
Lactate Dehydrogenase Level ◽  
Hypoxic Ischemic Encephalopathy ◽  
Discriminative Ability ◽  
Frequent Seizure ◽  
Ischemic Encephalopathy

Introduction. Hypoxic-ischemic encephalopathy (HIE) is defined as a neurological complication that results from perinatal asphyxia. Previous studies had investigated various markers to early detect HIE; however, these markers appeared to have several drawbacks, especially in resource-limited settings. Aim. This study aimed at evaluating the predictive value of the salivary lactate dehydrogenase level as a potential predictor of hypoxic-ischemic encephalopathy for newborns. Materials and Methods. We included 30 neonates with HIE due to perinatal asphyxia and 30 healthy newborns that serve as controls, admitted at the intensive care unit for neonates and maternity ward at Ismailia area Clinics and Hospitals. We measured the LDH levels by using saliva samples that were collected for neonates maximum by 12 h after birth. Results. It was found that patients with HIE had a statistically significant higher salivary LDH level (1927 ± 390.3 IU/L) than patients without HIE (523.6 ± 142.8 IU/L) ( p < 0.001 ). Moreover, salivary LDH showed a good discriminative ability where the AUC was 0.966 regarding salivary LDH (95% CI: 0.917–1.0) ( p < 0.001 ). The best cutoff value was 1420 IU/L or more which showed the best results in predicting the occurrence of HIE with 98.3% and 97.6% sensitivity and specificity, respectively. Conclusion. Salivary LDH can be considered as a useful noninvasive laboratory marker that can accurately predict HIE incidence among neonates with asphyxia within 12 hours from birth. The cases in the HIE group were assigned into three stages according to the Sarnat and Sarnat staging system: stage I: mild (irritable, normal, or hypertonia and poor feeding); stage II: moderate (lethargy, hypotonia, and frequent seizure); stage III: severe (coma, flaccid, absent reflexes, and frequent seizure). There is a positive association between LDH levels and the severity of HIE.

scholarly journals Correlation of serum creatinine kinase muscle-brain fraction and lactate dehydrogenase with severity of hypoxic ischemic encephalopathy in perinatal asphyxia in term neonates

2018 ◽  
Vol 5 (2) ◽  
pp. 405
Author(s):  
Masaraddi Sanjay K. ◽  
Ahamed Roshan P. M. ◽  
Nedunchezhian P. ◽  
Sulekha C.
Keyword(s):  
Lactate Dehydrogenase ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Term Neonate ◽  
Creatinine Kinase ◽  
Hypoxic Ischemic Encephalopathy ◽  
Case Group ◽  
Term Neonates ◽  
Mortality And Morbidity ◽  
Ischemic Encephalopathy

Background: Birth asphyxia in neonates significantly contributes to their mortality and morbidity, as it leads to hypoxic ischemic encephalopathy (HIE) and multi organ dysfunction. The present study was conducted with an objective to ascertain whether serum levels of creatinine kinase muscle-brain fraction (CK-MB) and lactate dehydrogenase (LDH) can distinguish an asphyxiated from a non-asphyxiated term neonate and correlation of these enzymes cut-off levels with severity of HIE in asphyxiated term neonates.Methods: This prospective study was conducted at Sree Mookambika Institute of Medical Sciences, Kulasekharam, Kanyakumari from September 2012 to December 2013. The study included 50 cases (asphyxiated neonates) and 50 controls (non-asphyxiated neonates) after fulfilling the requirements of inclusion criteria. Their blood samples were collected at 8±2 hours and 72±2 hours of age for estimation of CK-MB and LDH respectively and sent for analysis. The values were compared between cases and controls by using descriptive statistics.Results: The mean CK-MB level at 8±2 hours and mean LDH level at 72±2 hours were significantly higher in cases compared to controls with p<0.001. Among the 50 neonates in case group, 19 (38%) had clinical evidence of HIE. Of them 3 (6%) had mild HIE, 12 (24%) had moderate HIE and 4 (8%) had severe HIE during the course in NICU. The correlation of Apgar scores of 0-3 and 4-6 at 1 minute and 5 minutes with the severity of HIE and the correlation of cut-off CK-MB level of 92.6 U/L and cut-off LDH level of 580 U/L with the severity of HIE were not significant (p>0.05).Conclusions: We conclude that estimating the levels CK-MB at 8 hours of life and LDH at 72 hours of life can help to distinguish an asphyxiated from a non-asphyxiated term neonate with reasonable degree of accuracy but the enzyme cut-off levels do not correlate with severity of HIE in asphyxiated term neonates. 

Rare Treatable Cause of Demyelinating Leukoencephalopathy That One Cannot Afford to Miss

2020 ◽  
Author(s):  
Vykuntaraju K. Gowda ◽  
Sukanya Vignesh ◽  
Balamurugan Nagarajan ◽  
Varunvenkat M. Srinivasan ◽  
Manojna Battina ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Biotinidase Deficiency ◽  
Diagnosis And Treatment ◽  
Hypoxic Ischemic Encephalopathy ◽  
First Year ◽  
Diagnostic Challenge ◽  
First Year Of Life ◽  
Biotin Supplementation ◽  
Ischemic Encephalopathy ◽  
Unusual Finding

AbstractBiotinidase deficiency is a treatable neurometabolic disorder. It usually presents during the first year of life with seizures, ataxia, hypotonia, vision and hearing disturbance, alopecia, and skin rashes. It can have various neuroimaging findings but demyelinating leukoencephalopathy is an unusual finding in children with biotinidase deficiency that can cause diagnostic challenge as it can radiologically mimic perinatal hypoxic–ischemic encephalopathy or other leukodystrophies. It reverses with early diagnosis and treatment with biotin supplementation and the outcome is rewarding.

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