Effects of Gly71Arg mutation in UGT1A1 gene on neonatal hyperbilirubinemia: a systematic review and meta-analysis

2017 ◽  
Vol 32 (10) ◽  
pp. 1575-1585 ◽  
Author(s):  
Hassan Mehrad-Majd ◽  
Monir Sadat Haerian ◽  
Javad Akhtari ◽  
Yalda Ravanshad ◽  
Anoush Azarfar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Neonatal Hyperbilirubinemia ◽  
Ugt1a1 Gene

scholarly journals Association of Neonatal Hyperbilirubinemia with UGT1A1 Gene Polymorphisms: A Meta-Analysis

2015 ◽  
Vol 21 ◽  
pp. 3104-3114 ◽  
Author(s):  
Zibi Yu ◽  
Kaichang Zhu ◽  
Li Wang ◽  
Ying Liu ◽  
Jianmei Sun
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Neonatal Hyperbilirubinemia ◽  
Ugt1a1 Gene

scholarly journals The role of UGT1A1 (c.-3279 T > G) gene polymorphisms in neonatal hyperbilirubinemia susceptibility

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Zijin Li ◽  
Li Song ◽  
Lihong Hao
Keyword(s):  
Meta Analysis ◽  
Neonatal Hyperbilirubinemia ◽  
Cochrane Library ◽  
Common Disease ◽  
Homozygous State ◽  
Ugt1a1 Gene ◽  
The Cochrane Library ◽  
Allele Model ◽  
Increased Susceptibility

Abstract Background Neonatal hyperbilirubinemia (NNH) is a common disease in newborns. This research study aimed to assess the associations between uridine diphospho-glucuronate-glucuronosyltransferase 1A1 (UGT1A1, c.-3279 T > G) polymorphisms and NNH risk. Methods We searched PubMed, the Cochrane Library, and the Embase electronic databases. All published eligible studies before July 1, 2019, were searched for this meta-analysis. Results We identified 7 independent studies including 1560 cases. The data showed that in the general population, compared with the GT + GG vs TT and GG vs TT, c.-3279 T > G (rs4124874) was significantly related to a higher NNH risk (GG vs TT: OR = 1.865, 95% CI: 1.031–3.373, P = 0.039; GT + GG vs TT: OR = 1.331, 95% CI: 1.055–1.679, P = 0.016). Although not statistically significant, the data showed that c.3279 T > G had a tendency to be associated with NNH under the allele model and GG vs GT + TT in the overall population (G vs T: OR = 1.288, 95% CI: 0.982–1.689, P = 0.067; GG vs TT + GT: OR = 1.583, 95% CI: 0.947–2.647, P = 0.080). Conclusion The UGT1A1 gene c.-3279 T > G (rs4124874) polymorphism increased susceptibility to NNH, especially for the comparison of GT + GG vs TT and GG vs TT. In the future, we can use homozygous state of the UGT1A1 gene c.-3279 T > G (rs4124874) polymorphism for the diagnosis and screening of molecular biomarkers in NNH patients.

scholarly journals GP237 The use of massage therapy for treatment of neonatal hyperbilirubinemia: a systematic review and network meta-analysis

2019 ◽  
Author(s):  
Mohammed Abdelrahman ◽  
Nguyen Lam Vuong ◽  
Gehad Tawfik ◽  
Do Phuc Nhu Nguyen ◽  
Le Van Thanh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Massage Therapy ◽  
Neonatal Hyperbilirubinemia

scholarly journals The impact of SLCO1B1 genetic polymorphisms on neonatal hyperbilirubinemia: a systematic review with meta-analysis

2013 ◽  
Vol 89 (5) ◽  
pp. 434-443 ◽  
Author(s):  
Jiebo Liu ◽  
Jun Long ◽  
Shaofang Zhang ◽  
Xiaoyan Fang ◽  
Yuyuan Luo
Keyword(s):  
Systematic Review ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Neonatal Hyperbilirubinemia ◽  
The Impact

scholarly journals Prevalence of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Yared Asmare Aynalem ◽  
Getaneh Baye Mulu1 ◽  
Tadesse Yirga Akalu ◽  
Wondimeneh Shibabaw Shiferaw
Keyword(s):  
Systematic Review ◽  
G6pd Deficiency ◽  
Meta Analysis ◽  
Cochrane Review ◽  
Neonatal Hyperbilirubinemia ◽  
Blood Type ◽  
Sub Saharan Africa ◽  
Inconsistency Index ◽  
Sub Saharan ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract Background: Severe indirect hyperbilirubinemia is a silent cause of newborn disease and death worldwide. However, studies of the disease in sub-Saharan Africa are highly variable with respect to its prevalence. Hence, this study aimed to estimate the overall magnitude of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase (GP6D) deficiency and blood type incompatibility in sub-Saharan Africa.Methods: PubMed, Scopus, Google Scholar, and the Cochrane Review were systematically searched online to retrieve hyperbilirubinemia-related articles. All observational studies reported the prevalence of hyperbilirubinemia in sub-Saharan Africa were included for analysis and excluded if the study failed to determine the desired outcome. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed. Heterogeneity across the included studies was evaluated using the inconsistency index (I2). Publication bias was examined by funnel plot and the Egger’s regression test. The random-effect model was fitted to estimate the pooled prevalence of neonatal hyperbilirubinemia among patients in Sub Saharan Africa. The meta-analysis was performed using the STATA™ version 14 software.Results: A total of 30,486 studies were collected from the different databases and 10 articles were included for the final analysis. The overall magnitude of neonatal hyperbilirubinemia was 28.08 % (95% CI: (20.23, 35.94)) in sub-Saharan Africa. Neonates with G6PD deficiency were 2.42 times (95% CI: 1.64, 3.56) more likely to develop hyperbilirubinemia as compared to infants with normal G6PD levels. Moreover, the risk of developing hyperbilirubinemia was 3.3 times (95% CI: 1.96, 5.72) higher among neonates that had a blood type that was incompatible with their mother’s.Conclusion: The failure to prevent and screen G6PD deficiency and blood type incompatibility with their mother’s results in high burden of neonatal hyperbilirubinemia in sub-Saharan Africa. Therefore, early identification and care strategies should be developed to the affected neonates with G6PD deficiency and blood type incompatibility with their mother’s to address long-term medical and scholastic damages among those exposed to severe hyperbilirubinemia

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