Short-term outcomes comparison between preterm infants with and without acute hypoxic respiratory failure attributable to presumed pulmonary hypoplasia after prolonged preterm premature rupture of membranes before 25 gestational weeks

AbstractPreterm premature rupture of membranes (PPROM) occurs in up to 3% of all pregnancies. Only few comparative studies have investigated potential risks and benefits between different tocolytic substances in women with PPROM. The aim of this study was to compare the neonatal short term outcome after tocolysis with Atosiban or Hexoprenaline in women with PPROM. This is a retrospective observational cohort study of women with PPROM between 24 and 32 weeks of gestation comparing neonatal and maternal outcome after tocolysis with atosiban or hexoprenaline. Outcome parameters were short term neonatal outcome, maternal tocolytic efficacy, effectiveness and tolerability and neonatal neurodevelopmental long-term outcome. Continuous variables were compared using t-Test or Mann–Whitney U test, as appropriate. For categorical variables Chi-square after Pearson and Fisher exact-test were used to compare the two groups. 93 women were included into this study with 42 women receiving hexoprenaline and 51 women receiving atosiban as primary tocolytic treatment. Mean gestational age was 29 weeks in both groups at the time PPROM. No differences were found for any short term neonatal outcome parameters, tocolytic efficacy, effectiveness and tolerability and neonatal neurodevelopmental long-term outcome. Both hexoprenaline and atosiban do not affect the short and long term neonatal outcome in women with PPROM for the time of lung maturation.

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Is There a Role for Placental Cultures in Cases of Clinical Chorioamnionitis Complicating Preterm Premature Rupture of Membranes?

American Journal of Perinatology ◽

10.1055/s-0037-1600128 ◽

2017 ◽

Vol 34 (09) ◽

pp. 867-873 ◽

Cited By ~ 1

Author(s):

Ariel Many ◽

Rotem Orbach ◽

Udi Shapira ◽

Sharon Amit ◽

Galia Grisaru-Soen ◽

...

Keyword(s):

Neonatal Outcome ◽

Negative Group ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Short Term ◽

Preterm Premature Rupture ◽

Group A ◽

Group B ◽

Culture Positive ◽

Culture Negative

Objective To assess the role of placental cultures in cases of preterm premature rupture of membranes (PPROM) complicated by chorioamnionitis and to determine the effect of positive cultures on short-term neonatal outcomes. Design A retrospective single-center study. The medical records of all women with PPROM between January 1, 2011, and December 31, 2015, were reviewed. Cases were divided into placental culture positive (group A) and placental culture negative (group B) groups. Maternal and pregnancy characteristics as well as short-term neonatal outcomes were compared between groups. Results During the 5-year study period, 61 cases of clinical chorioamnionitis complicating PPROM were diagnosed: 25 cases were culture positive (group A) and 36 were culture negative (group B). Neonatal outcome measures, including Apgar score at 5 minutes (p = 0.028; odds ratio [OR]: 5.27; confidence interval [CI]: 1.19–23.34), respiratory distress syndrome (p = 0.026; OR: 4.11; CI: 1.18–14.25), and neonatal infection (p < 0.0001; OR: 11.59; CI: 3.37–39.87) were significantly more common in group A newborns, regardless of gestational age at delivery as was the composite neonatal outcome (p = 0.017; OR: 7.35: CI: 1.42–37.79). Placental isolates were primarily Streptococci and Escherichia coli. Conclusion Placental cultures may be an essential predictor of neonatal morbidity in PPROM and may contribute to the modification of neonatal treatment.

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Temporary Fetoscopic Tracheal Balloon Occlusion Enhanced by Hyperoncotic Lung Distension: Is There a Role in the Treatment of Fetal Pulmonary Hypoplasia from Early Preterm Premature Rupture of Membranes?

Fetal Diagnosis and Therapy ◽

10.1159/000106356 ◽

2007 ◽

Vol 22 (6) ◽

pp. 462-465 ◽

Cited By ~ 10

Author(s):

Thomas Kohl ◽

Andreas Müller ◽

Axel Franz ◽

Axel Heep ◽

Winfried A. Willinek ◽

...

Keyword(s):

Pulmonary Hypoplasia ◽

Balloon Occlusion ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture

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Neonatal Outcomes In Women With Preterm Premature Rupture of Membranes At Periviable Gestational Age

10.21203/rs.3.rs-1165298/v1 ◽

2022 ◽

Author(s):

Jacky Herzlich ◽

Laurence Mangel ◽

Ariel Halperin ◽

Daniel Lubin ◽

Ronella Marom

Keyword(s):

Survival Rate ◽

Preterm Infants ◽

Gestational Age ◽

Neonatal Outcomes ◽

High Survival ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Membrane Rupture ◽

Preterm Premature Rupture ◽

Gestational Week

Abstract Purpose: To examine the outcomes of preterm infants born to women with preterm premature rupture of membranes at periviable gestational age.Methods: This is a retrospective study analyzing data on singleton deliveries complicated by prolonged premature rupture of membranes occurring before 24 weeks of gestation. Neonatal outcomes including birth weight, Apgar score, retinopathy of prematurity, intraventricular hemorrhage, bronchopulmonary dysplasia, necrotizing enterocolitis, hearing impairment and mortality were evaluated.Results: Ninety four preterm infants who were born after a prolonged premature rupture of membranes of at least 7 days were included in the study.Median gestational week at onset of membrane rupture was 27.1 ± 4.2 weeks (range 17 - 33) and median latency period in days was 16 ± 21.8 (range 7 - 105). We found that the survival rate to discharge within neonates born after prolonged rupture of membrane at gestational week less than 24 weeks is 79.2%. These neonates did not show an increased rate of major morbidities compared to neonates born following membrane rupture at gestational week 24 to 27. Conclusion: We described a high survival rate without major morbidities following prolonged preterm membrane rupture before viability.

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