A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge

2019 ◽  
pp. 1-4
Author(s):  
Peng Zhao ◽  
Li-Li Lou ◽  
Hao Zhang ◽  
Rui Guo ◽  
Xiao-Bo Wang ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Crataegus Pinnatifida ◽  
Β Amyloid ◽  
Aggregation Activity

Synthesis of derivatives of cleistopholine and their anti-acetylcholinesterase and anti-β-amyloid aggregation activity

2018 ◽  
Vol 76 ◽  
pp. 228-236 ◽  
Author(s):  
Zhenhua Wu ◽  
Wenxia Liao ◽  
Kelin Chen ◽  
Jingfang Qin ◽  
Huang Tang
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Activity ◽  
Derivatives Of

Anti-β-amyloid aggregation activity of enantiomeric furolactone-type lignans from Archidendron clypearia (Jack) I.C.N.

2018 ◽  
Vol 34 (4) ◽  
pp. 456-463 ◽  
Author(s):  
Yu-Xi Wang ◽  
Bin Lin ◽  
Le Zhou ◽  
Zhi-Yang Yan ◽  
Han Zhang ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Activity

Triterpenes from Archidendron clypearia (Jack) I.C.N. with anti-β-amyloid aggregation activity

2019 ◽  
pp. 1-4
Author(s):  
Yu-Xi Wang ◽  
Zhi-Kang Duan ◽  
Ye Chang ◽  
Zhi-Yang Yan ◽  
Xiao-Bo Wang ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Activity

Two new sesquineolignans from the seeds of Crataegus pinnatifida and their β-amyloid aggregation inhibitory activitiy

2018 ◽  
Vol 33 (17) ◽  
pp. 2446-2452 ◽  
Author(s):  
Rui Guo ◽  
Le Zhou ◽  
Peng Zhao ◽  
Xiao-Bo Wang ◽  
Xiao-Xiao Huang ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Crataegus Pinnatifida ◽  
Β Amyloid

Lignans from the seeds of Chinese hawthorn (Crataegus pinnatifida var. major N.E.Br.) against β-amyloid aggregation

2017 ◽  
Vol 32 (14) ◽  
pp. 1706-1713 ◽  
Author(s):  
Xiao-Xiao Huang ◽  
Yang Xu ◽  
Ming Bai ◽  
Le Zhou ◽  
Shao-Jiang Song ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Crataegus Pinnatifida ◽  
Β Amyloid

Enantiomeric lignans with anti-β-amyloid aggregation activity from the twigs and leaves of Pithecellobium clypearia Benth

2018 ◽  
Vol 77 ◽  
pp. 579-585 ◽  
Author(s):  
Yu-Xi Wang ◽  
Le Zhou ◽  
Jie Wang ◽  
Bin Lin ◽  
Xiao-Bo Wang ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Activity

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines

2012 ◽  
Vol 33 (3) ◽  
pp. 482-490 ◽  
Author(s):  
Shao-wei Wang ◽  
Yu-Jiong Wang ◽  
Ya-jing Su ◽  
Wei-wei Zhou ◽  
Shi-gao Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Proinflammatory Cytokines ◽  
Amyloid Aggregation ◽  
Β Amyloid
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