Label-free detection of ApoE4-mediated β-amyloid aggregation on single nanoparticle uncovering Alzheimer's disease

2015 ◽  
Vol 72 ◽  
pp. 197-204 ◽  
Author(s):  
Min Kyung Kang ◽  
Jeewon Lee ◽  
Anh H. Nguyen ◽  
Sang Jun Sim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Label Free ◽  
Amyloid Aggregation ◽  
Single Nanoparticle ◽  
Label Free Detection ◽  
Β Amyloid

Label-free detection of β-amyloid peptides (Aβ40 and Aβ42): a colorimetric sensor array for plasma monitoring of Alzheimer's disease

Nanoscale ◽  
2018 ◽  
Vol 10 (14) ◽  
pp. 6361-6368 ◽  
Author(s):  
Forough Ghasemi ◽  
M. Reza Hormozi-Nezhad ◽  
Morteza Mahmoudi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sensor Array ◽  
Colorimetric Sensor ◽  
Label Free ◽  
Aβ Peptides ◽  
Amyloid Peptides ◽  
Colorimetric Sensor Array ◽  
Label Free Detection ◽  
Β Amyloid

A nanoparticle-based colorimetric sensor array for identification of structurally similar Aβ peptides (Aβ40 and Aβ42) for monitoring of Alzheimer's disease at early stages.

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

Lipophilic ferulic acid derivatives protect PC12 cells against oxidative damage via modulating β-amyloid aggregation and activating Nrf2 enzymes

2020 ◽  
Vol 11 (5) ◽  
pp. 4707-4718 ◽  
Author(s):  
Yu Wu ◽  
Yu-gang Shi ◽  
Xiao-liang Zheng ◽  
Ya-li Dang ◽  
Chen-min Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Damage ◽  
Ferulic Acid ◽  
Pc12 Cells ◽  
Amyloid Beta ◽  
Neuroprotective Effect ◽  
Amyloid Aggregation ◽  
Β Amyloid

Ferulic acid (FA) has been shown to have a neuroprotective effect on Alzheimer's disease induced by amyloid-beta (Aβ) neurotoxicity.

Inhibition of Alzheimer's disease β‐amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy

2001 ◽  
Vol 15 (7) ◽  
pp. 1297-1299 ◽  
Author(s):  
Fernanda G. Felice ◽  
Jean-Christophe Houzel ◽  
José Garcia-Abreu ◽  
Paulo Roberto F. Louzada ◽  
Rosenilde C. Afonso ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Aggregation ◽  
Β Amyloid
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