Anti-β-amyloid aggregation activity of enantiomeric furolactone-type lignans from Archidendron clypearia (Jack) I.C.N.

2018 ◽  
Vol 34 (4) ◽  
pp. 456-463 ◽  
Author(s):  
Yu-Xi Wang ◽  
Bin Lin ◽  
Le Zhou ◽  
Zhi-Yang Yan ◽  
Han Zhang ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Activity

Synthesis of derivatives of cleistopholine and their anti-acetylcholinesterase and anti-β-amyloid aggregation activity

2018 ◽  
Vol 76 ◽  
pp. 228-236 ◽  
Author(s):  
Zhenhua Wu ◽  
Wenxia Liao ◽  
Kelin Chen ◽  
Jingfang Qin ◽  
Huang Tang
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Activity ◽  
Derivatives Of

Triterpenes from Archidendron clypearia (Jack) I.C.N. with anti-β-amyloid aggregation activity

2019 ◽  
pp. 1-4
Author(s):  
Yu-Xi Wang ◽  
Zhi-Kang Duan ◽  
Ye Chang ◽  
Zhi-Yang Yan ◽  
Xiao-Bo Wang ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Activity

Enantiomeric lignans with anti-β-amyloid aggregation activity from the twigs and leaves of Pithecellobium clypearia Benth

2018 ◽  
Vol 77 ◽  
pp. 579-585 ◽  
Author(s):  
Yu-Xi Wang ◽  
Le Zhou ◽  
Jie Wang ◽  
Bin Lin ◽  
Xiao-Bo Wang ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Activity

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines

2012 ◽  
Vol 33 (3) ◽  
pp. 482-490 ◽  
Author(s):  
Shao-wei Wang ◽  
Yu-Jiong Wang ◽  
Ya-jing Su ◽  
Wei-wei Zhou ◽  
Shi-gao Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Proinflammatory Cytokines ◽  
Amyloid Aggregation ◽  
Β Amyloid

Role of Acetylcholinesterase in β-Amyloid Aggregation Studied by Accelerated Molecular Dynamics

2016 ◽  
Vol 7 (2) ◽  
pp. 396-402 ◽  
Author(s):  
Sofya V. Lushchekina ◽  
Ekaterina D. Kots ◽  
Dana A. Novichkova ◽  
Konstantin A. Petrov ◽  
Patrick Masson
Keyword(s):  
Molecular Dynamics ◽  
Amyloid Aggregation ◽  
Accelerated Molecular Dynamics ◽  
Β Amyloid
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