Role of Ribavirin in the Era of Direct–Acting Antiviral Therapies of Chronic Hepatitis C

2020 ◽  
Vol 18 (8) ◽  
pp. 817-822
Author(s):  
Omkolsoum Alhaddad ◽  
Ahmed Wahb ◽  
Alyaa Sabry ◽  
Fatma Khalil ◽  
Dalia Elsabaawy ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Direct Acting Antiviral ◽  
Antiviral Therapies ◽  
Direct Acting

scholarly journals Patient-reported symptoms during and after direct-acting antiviral therapies for chronic hepatitis C: The PROP UP study

2019 ◽  
Vol 71 (3) ◽  
pp. 486-497 ◽  
Author(s):  
Donna M. Evon ◽  
Souvik Sarkar ◽  
Jipcy Amador ◽  
Anna S. Lok ◽  
Richard K. Sterling ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Direct Acting Antiviral ◽  
Antiviral Therapies ◽  
Patient Reported ◽  
Direct Acting

Early Virologic Responses and Hematologic Safety of Direct-Acting Antiviral Therapies in Veterans With Chronic Hepatitis C

2013 ◽  
Vol 11 (8) ◽  
pp. 1021-1027 ◽  
Author(s):  
Pamela S. Belperio ◽  
Elizabeth W. Hwang ◽  
I. Chun Thomas ◽  
Larry A. Mole ◽  
Ramsey C. Cheung ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Direct Acting Antiviral ◽  
Antiviral Therapies ◽  
Direct Acting

Predictors of adverse drug reactions associated with ribavirin in direct‐acting antiviral therapies for chronic hepatitis C

2019 ◽  
Vol 28 (12) ◽  
pp. 1601-1608
Author(s):  
Camille Nigri Cursino ◽  
Priscilla Garcia de Oliveira Monteiro ◽  
Gabriel da Silva Duarte ◽  
Tassita Bezz Quintanilha Vieira ◽  
Verônica de Carvalho Crisante ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Direct Acting Antiviral ◽  
Antiviral Therapies ◽  
Direct Acting

scholarly journals Patients’ preferences for treatment with the new direct acting antiviral therapies for chronic hepatitis C virus infection

2021 ◽  
Vol 23 (2) ◽  
pp. 67-75
Author(s):  
MA Simón ◽  
O Rojo ◽  
P Ryan
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Descriptive Analysis ◽  
Treatment Preference ◽  
Hepatitis C Infection ◽  
Direct Acting Antiviral ◽  
Antiviral Therapies ◽  
Treatment Naïve ◽  
Direct Acting

Objectives: The efficacy of new direct-acting antivirals (DAAs) in treating hepatitis C infection can depend on treatment adherence, which may be influenced by the patient’s current lack of awareness of the disease. This study set out to understand the treatment naïve chronic hepatitis C patients’ preferences for new DAAs (attributes) and to compile information about the diagnosis process. Material and method: Spanish quantitative market research study conducted between November 2018 and January 2019 to assess the posology preferences of treatment-naïve patients with chronic hepatitis C before starting treatment (seen by hepatologists and infectious diseases specialists). A telephone interview was carried out to collect demographic, diagnostic and treatment preference data, consisting of two dosing OPTIONS: 1) three tablets/day (single dose), at the same time, with food (8 weeks). 2) single tablet/day, at any time with/without food (12 weeks). A descriptive analysis of pooled results was performed. Results: 104 patients (mean age: 49 years) with hepatitis C diagnosed 7.3±9.7 years ago (average), mainly in primary care (PC) (42%). The most common reasons for not having started treatment were health problems/comorbidities (31%). Fifty-eight percent of patients were not informed about the available treatments. Seventy-two percent of patients preferred a simple tablet/day, at any time, with/without food (12 weeks), and considered compatibility with other treatments, side effects, ease of administration, treatment duration and the number of tablets to be very important. Discussion: Patient preferences are mainly driven by dosing flexibility and simplicity, including freedom to take the medication with/without food. The role of PC in the diagnosis should be taken into account. There are still patients who are untreated after diagnosis.

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