Inhibitory Effects of Cedrol, β-Cedrene, and Thujopsene on Cytochrome P450 Enzyme Activities in Human Liver Microsomes

2014 ◽  
Vol 77 (22-24) ◽  
pp. 1522-1532 ◽  
Author(s):  
Hyeon-Uk Jeong ◽  
Soon-Sang Kwon ◽  
Tae Yeon Kong ◽  
Ju Hyun Kim ◽  
Hye Suk Lee
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
Inhibitory Effects ◽  
P450 Enzyme

Inhibitory effects of aschantin on cytochrome P450 enzyme activities in human liver microsomes

2017 ◽  
Vol 32 (1) ◽  
pp. S56
Author(s):  
Wongu Choi ◽  
Soon Sang Kwon ◽  
Tae Yeon Kong ◽  
Ju-Hyun Kim ◽  
Yong Yeon Cho ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
Inhibitory Effects ◽  
P450 Enzyme

scholarly journals Effects of Eupatilin and Jaceosidin on Cytochrome P450 Enzyme Activities in Human Liver Microsomes

Molecules ◽  
2010 ◽  
Vol 15 (9) ◽  
pp. 6466-6475 ◽  
Author(s):  
Hye Young Ji ◽  
Sung Yeon Kim ◽  
Dong Kyun Kim ◽  
Ji Hyun Jeong ◽  
Hye Suk Lee
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme

In vitrometabolism of obovatol and its effect on cytochrome P450 enzyme activities in human liver microsomes

2013 ◽  
Vol 34 (4) ◽  
pp. 195-202 ◽  
Author(s):  
Jeongmin Joo ◽  
Doohyun Lee ◽  
Zhexue Wu ◽  
Jung-Hoon Shin ◽  
Hye Suk Lee ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme

Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomes

2005 ◽  
Vol 155 (1-2) ◽  
pp. 62-70 ◽  
Author(s):  
A. Matthias ◽  
E.M.J. Gillam ◽  
K.G. Penman ◽  
N.J. Matovic ◽  
K.M. Bone ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme

Inhibitory Effects of Garcinia cambogia Extract on CYP2B6 Enzyme Activity

Planta Medica ◽  
2017 ◽  
Vol 83 (11) ◽  
pp. 895-900 ◽  
Author(s):  
Jun Yu ◽  
Min Choi ◽  
Jong Park ◽  
Shaheed Rehman ◽  
Katsunori Nakamura ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
Dependent Manner ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Concentration Dependent Manner ◽  
Garcinia Cambogia ◽  
P450 Enzyme

AbstractThis study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner. Furthermore, the inhibition was potentiated following preincubation with NADPH, indicating that G. cambogia extract is a time-dependent inhibitor of CYP2B6. Meanwhile, hydroxycitric acid, the major bioactive ingredient of G. cambogia extract, did not exhibit significant inhibition effects on cytochrome P450 enzyme activities. G. cambogia extract could modulate the pharmacokinetics of CYP2B6 substrate drugs and lead to interactions with those drugs. Therefore, caution may be required with respect to concomitant intake of dietary supplements containing G. cambogia extract with CYP2B6 substrates.

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