scholarly journals The combination of artificial intelligence and systems biology for intelligent vaccine design

2020 ◽  
Vol 15 (11) ◽  
pp. 1267-1281
Author(s):  
Giulia Russo ◽  
Pedro Reche ◽  
Marzio Pennisi ◽  
Francesco Pappalardo
2018 ◽  
Vol 74 (11) ◽  
pp. 1343-1351
Author(s):  
Yoshiyuki Asai ◽  
Takeshi Abe ◽  
Takahide Hayano

2021 ◽  
pp. 121-142
Author(s):  
S. Dhivya ◽  
S. Hari Priya ◽  
R. Sathishkumar

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Daniel Berrar ◽  
Naoyuki Sato ◽  
Alfons Schuster

Since its conception in the mid 1950s, artificial intelligence with its great ambition to understand and emulate intelligence in natural and artificial environments alike is now a truly multidisciplinary field that reaches out and is inspired by a great diversity of other fields. Rapid advances in research and technology in various fields have created environments into which artificial intelligence could embed itself naturally and comfortably. Neuroscience with its desire to understand nervous systems of biological organisms and systems biology with its longing to comprehend, holistically, the multitude of complex interactions in biological systems are two such fields. They target ideals artificial intelligence has dreamt about for a long time including the computer simulation of an entire biological brain or the creation of new life forms from manipulations of cellular and genetic information in the laboratory. The scope for artificial intelligence in neuroscience and systems biology is extremely wide. This article investigates the standing of artificial intelligence in relation to neuroscience and systems biology and provides an outlook at new and exciting challenges for artificial intelligence in these fields. These challenges include, but are not necessarily limited to, the ability to learn from other projects and to be inventive, to understand the potential and exploit novel computing paradigms and environments, to specify and adhere to stringent standards and robust statistical frameworks, to be integrative, and to embrace openness principles.


2011 ◽  
Vol 5 (2) ◽  
pp. 295-304 ◽  
Author(s):  
Adrien Six ◽  
Bertrand Bellier ◽  
Véronique Thomas-Vaslin ◽  
David Klatzmann

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yifan Xue ◽  
Michael Q. Ding ◽  
Xinghua Lu

Abstract Cellular signaling systems play a vital role in maintaining homeostasis when a cell is exposed to different perturbations. Components of the systems are organized as hierarchical networks, and perturbing different components often leads to transcriptomic profiles that exhibit compositional statistical patterns. Mining such patterns to investigate how cellular signals are encoded is an important problem in systems biology, where artificial intelligence techniques can be of great assistance. Here, we investigated the capability of deep generative models (DGMs) to modeling signaling systems and learn representations of cellular states underlying transcriptomic responses to diverse perturbations. Specifically, we show that the variational autoencoder and the supervised vector-quantized variational autoencoder can accurately regenerate gene expression data in response to perturbagen treatments. The models can learn representations that reveal the relationships between different classes of perturbagens and enable mappings between drugs and their target genes. In summary, DGMs can adequately learn and depict how cellular signals are encoded. The resulting representations have broad applications, demonstrating the power of artificial intelligence in systems biology and precision medicine.


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