An update on the importance of plasma protein binding in drug discovery and development

2021 ◽  
pp. 1-13
Author(s):  
Li Di
Keyword(s):  
Drug Discovery ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Drug Discovery And Development

Plasma Protein Binding in Drug Discovery and Development

2010 ◽  
Vol 13 (2) ◽  
pp. 170-187 ◽  
Author(s):  
Monique Howard ◽  
John Hill ◽  
Gerald Galluppi ◽  
Matthew McLean
Keyword(s):  
Drug Discovery ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Drug Discovery And Development

The Role of Plasma Protein Binding in Drug Discovery

2007 ◽  
pp. 119-141 ◽  
Author(s):  
Roger E. Fessey ◽  
Rupert P. Austin ◽  
Patrick Barton ◽  
Andrew M. Davis ◽  
Mark C. Wenlock
Keyword(s):  
Drug Discovery ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein

Species differences in drug plasma protein binding

MedChemComm ◽  
2014 ◽  
Vol 5 (7) ◽  
pp. 963-967 ◽  
Author(s):  
Nicola Colclough ◽  
Linette Ruston ◽  
J. Matthew Wood ◽  
Philip A. MacFaul
Keyword(s):  
Drug Discovery ◽  
Protein Binding ◽  
Human Plasma ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Plasma Proteins ◽  
Species Differences ◽  
Human Plasma Protein ◽  
Binding Data ◽  
Drug Plasma

Comparison of the human plasma protein binding data for a variety of drug discovery compounds indicates that compounds tend to be slightly more bound to human plasma proteins, than compared to plasma proteins from rats, dogs or mice.

scholarly journals Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum

Bioanalysis ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 673-682 ◽  
Author(s):  
Brigitte Buscher ◽  
Sirpa Laakso ◽  
Hermann Mascher ◽  
Klaus Pusecker ◽  
Mira Doig ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Drug Development ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Binding Studies
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