scholarly journals What are the practical, ethical and pathobiological considerations in the use of minipigs as an animal model in drug discovery for acute radiation syndrome and delayed effects of acute radiation exposure?

2021 ◽  
Author(s):  
Doreswamy Kenchegowda ◽  
Thomas M. Seed ◽  
Vijay K. Singh
Keyword(s):  
Animal Model ◽  
Drug Discovery ◽  
Radiation Exposure ◽  
Acute Radiation ◽  
Acute Radiation Syndrome ◽  
Delayed Effects

Establishing Pediatric Mouse Models of the Hematopoietic Acute Radiation Syndrome and the Delayed Effects of Acute Radiation Exposure

2021 ◽  
Vol 195 (4) ◽  
Author(s):  
Andrea M. Patterson ◽  
Rajendran Sellamuthu ◽  
P. Artur Plett ◽  
Carol H. Sampson ◽  
Hui Lin Chua ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Mouse Models ◽  
Acute Radiation ◽  
Acute Radiation Syndrome ◽  
Delayed Effects

scholarly journals A Potential Role for Excess Tissue Iron in Development of Cardiovascular Delayed Effects of Acute Radiation Exposure

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Steven J. Miller ◽  
Supriya Chittajallu ◽  
Carol Sampson ◽  
Alexa Fisher ◽  
Joseph L. Unthank ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Potential Role ◽  
Acute Radiation ◽  
Delayed Effects ◽  
Tissue Iron

scholarly journals Drug discovery strategies for acute radiation syndrome

2019 ◽  
Vol 14 (7) ◽  
pp. 701-715 ◽  
Author(s):  
Vijay K. Singh ◽  
Thomas M. Seed ◽  
Ayodele O. Olabisi
Keyword(s):  
Drug Discovery ◽  
Acute Radiation ◽  
Acute Radiation Syndrome

scholarly journals Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS

2015 ◽  
Vol 109 (5) ◽  
pp. 511-521 ◽  
Author(s):  
Joseph L. Unthank ◽  
Steven J. Miller ◽  
Ariel K. Quickery ◽  
Ethan L. Ferguson ◽  
Meijing Wang ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Murine Model ◽  
Acute Radiation ◽  
Delayed Effects

Radiation dose is of limited clinical usefulness in persons with acute radiation syndrome

2019 ◽  
Author(s):  
Matthias Port ◽  
Matthäus Majewski ◽  
Michael Abend
Keyword(s):  
Radiation Exposure ◽  
Absorbed Dose ◽  
Exposure Dose ◽  
Acute Radiation ◽  
Radiation Quality ◽  
Acute Radiation Syndrome ◽  
Total Body ◽  
Relationship Of ◽  
The Relationship ◽  
Radiation Exposure Dose

Abstract The relation of radiation exposure (dose) with acute radiation syndrome (ARS) depends on many factors. In this overview, we reconsider (1) radiation exposure characteristics (e.g. radiation quality, fractionation, dose rate, partial/total body irradiation) and (2) biological processes (e.g. radiosensitivity, cell cycle dependency, oxygenation) affecting acute health effects after exposure. Furthermore we include evidence from recently published work that examined the relationship of absorbed dose and risk of clinically relevant ARS in persons exposed after a radiation accident. We introduce the concept of radiation-related bioindicators for effect prediction. Bioindicators are considered here to be factors that integrate multiple radiation exposure characteristics and cell- and molecular-based processes to improve clinical prediction in persons with ARS.

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