Radiation dose is of limited clinical usefulness in persons with acute radiation syndrome

2019 ◽  
Author(s):  
Matthias Port ◽  
Matthäus Majewski ◽  
Michael Abend
Keyword(s):  
Radiation Exposure ◽  
Absorbed Dose ◽  
Exposure Dose ◽  
Acute Radiation ◽  
Radiation Quality ◽  
Acute Radiation Syndrome ◽  
Total Body ◽  
Relationship Of ◽  
The Relationship ◽  
Radiation Exposure Dose

Abstract The relation of radiation exposure (dose) with acute radiation syndrome (ARS) depends on many factors. In this overview, we reconsider (1) radiation exposure characteristics (e.g. radiation quality, fractionation, dose rate, partial/total body irradiation) and (2) biological processes (e.g. radiosensitivity, cell cycle dependency, oxygenation) affecting acute health effects after exposure. Furthermore we include evidence from recently published work that examined the relationship of absorbed dose and risk of clinically relevant ARS in persons exposed after a radiation accident. We introduce the concept of radiation-related bioindicators for effect prediction. Bioindicators are considered here to be factors that integrate multiple radiation exposure characteristics and cell- and molecular-based processes to improve clinical prediction in persons with ARS.

Studi Paparan Radiasi pada Pekerja Radiasi Cathlab dengan Menggunakan My Dose Mini sebagai Upaya Keselamatan Radiasi di RSUP Adam Malik Medan

2021 ◽  
Vol 1 (1) ◽  
pp. 41-46
Author(s):  
Martua Damanik ◽  
◽  
Josepa ND Simanjuntak ◽  
Elvita Rahmi Daulay
Keyword(s):  
Radiation Exposure ◽  
Biological Effects ◽  
Exposure Dose ◽  
Radiological Protection ◽  
Safe Level ◽  
Radiation Sources ◽  
Radiation Worker ◽  
Radiation Workers ◽  
Effects Of Radiation ◽  
Radiation Exposure Dose

Cathlab radiation workers, when performing interventional procedures, are at high risk of the effects of radiation exposure. The risk of radiation exposure is deterministic and stochastic biological effects. Therefore, radiation exposure studies of radiation workers at the cath lab were conducted to determine the value of radiation exposure received. This radiation exposure study was conducted by measuring and recording radiation exposure doses received by radiation workers. Measurements are made when the radiation officer performs the intervention procedure. The research was carried out for one month in the cath lab room of the Adam Malik General Hospital, Medan. The modalities used are GE Medical System Interventional Fluoroscopy and Phillips Allura Xper FD20. The dosimeter used is “my dose mini”, which is placed inside a shield or apron worn by radiation workers. The size of the apron shield used is 0.50 mm Pb at the front and 0.25 mm Pb at the rear. Radiation officers whose radiation exposure dose was measured consisted of 10 doctors, 11 nurses, and one radiographer. Each inspection procedure of each radiation worker has a different distance, time, and shield from the radiation source. The measurement of radiation exposure dose is (1-59 μSv) for doctors, (1-58 μSv) for nurses, and 1 μSv for radiographers. To protect against radiation must pay attention to the factors of time, distance, and shielding. Ways that can do are to avoid being close to radiation sources for too long, keep a space at a safe level from radiation, and use shields such as Pb-coated aprons, use Pb gloves, Pb goggles, and thyroid protectors. The amount of radiation exposure dose received by each radiation worker at the time of measurement is still within the tolerance limit. The Nuclear Energy Regulatory Agency (BAPETEN) regulation, which the International Commission recommends on Radiological Protection (ICRP), is 20 mSv/year. The results of this study are expected to be used as input for improving the quality of service for monitoring radiation exposure doses in the Cathlab and as reference material for further research.

scholarly journals Mitigating Effects of 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) on Hematopoietic Acute Radiation Syndrome after Total-Body Ionizing Irradiation in Mice

2019 ◽  
Vol 192 (6) ◽  
pp. 602 ◽  
Author(s):  
Yong-Jae Kim ◽  
Jinseon Jeong ◽  
Su-Hyun Shin ◽  
Do Young Lee ◽  
Ki-Young Sohn ◽  
...  
Keyword(s):  
Acute Radiation ◽  
Ionizing Irradiation ◽  
Acute Radiation Syndrome ◽  
Total Body

scholarly journals Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome

2019 ◽  
Vol 60 (3) ◽  
pp. 308-317 ◽  
Author(s):  
Michael R Landauer ◽  
Adam J Harvey ◽  
Michael D Kaytor ◽  
Regina M Day
Keyword(s):  
Estrogen Receptor ◽  
Mechanism Of Action ◽  
Total Body Irradiation ◽  
Intramuscular Injection ◽  
Acute Radiation ◽  
Beta Agonist ◽  
Therapeutic Window ◽  
Acute Radiation Syndrome ◽  
Single Intramuscular Injection ◽  
Total Body

Abstract There are no FDA-approved drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic–acute radiation syndrome (H-ARS). A suspension of synthetic genistein nanoparticles was previously shown to be an effective radioprotectant against H-ARS when administered prior to exposure to a lethal dose of total body radiation. Here we aimed to determine the time to protection and the duration of protection when the genistein nanosuspension was administered by intramuscular injection, and we also investigated the drug’s mechanism of action. A single intramuscular injection of the genistein nanosuspension was an effective radioprotectant when given prophylactically 48 h to 12 h before irradiation, with maximum effectiveness occurring when administered 24 h before. No survival advantage was observed in animals administered only a single dose of drug after irradiation. The dose reduction factor of the genistein nanosuspension was determined by comparing the survival of treated and untreated animals following different doses of total body irradiation. As genistein is a selective estrogen receptor beta agonist, we also explored whether this was a central component of its radioprotective mechanism of action. Mice that received an intramuscular injection of an estrogen receptor antagonist (ICI 182,780) prior to administration of the genistein nanosuspension had significantly lower survival following total body irradiation compared with animals only receiving the nanosuspension (P < 0.01). These data define the time to and duration of radioprotection following a single intramuscular injection of the genistein nanosuspension and identify its likely mechanism of action.

Characterization of Radiation Exposure Dose Rate from Waste Dumpsites within Owerri, Nigeria: An Atmospheric Concern

2015 ◽  
Vol 11 (3) ◽  
pp. 1-9
Author(s):  
Ugochukwu Okoro ◽  
Ijeoma Dike ◽  
Chidiezie Chineke ◽  
Christiana Godwin ◽  
Chiamaka Chukwunyere
Keyword(s):  
Radiation Exposure ◽  
Dose Rate ◽  
Exposure Dose ◽  
Exposure Dose Rate ◽  
Radiation Exposure Dose
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