scholarly journals Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans

mAbs ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 1832861
Author(s):  
Armin Sepp ◽  
Mats Bergström ◽  
Marie Davies
Keyword(s):  
Binding Domain ◽  
Albumin Binding ◽  
Physiologically Based Pharmacokinetics ◽  
Domain Antibody ◽  
Physiologically Based ◽  
Species Cross

Utilizing LC-MS/MS to provide adaptable clinical bioanalytical support for an extended half-life bioactive peptide fused to an albumin-binding domain antibody

2015 ◽  
Vol 7 (1) ◽  
pp. 237-243 ◽  
Author(s):  
Chester L. Bowen ◽  
Jonathan Kehler ◽  
Thomas Mencken ◽  
Bonnie Orr ◽  
Matthew Szapacs
Keyword(s):  
Half Life ◽  
Bioactive Peptides ◽  
Binding Domain ◽  
The Body ◽  
Bioactive Peptide ◽  
Albumin Binding ◽  
Domain Antibody ◽  
Dosing Intervals

Bioactive peptides are often unstable in the body leading to short half lives and requiring frequent dosing intervals.

GSK2374697, a Novel Albumin-Binding Domain Antibody (AlbudAb), Extends Systemic Exposure of Exendin-4: First Study in Humans—PK/PD and Safety

2014 ◽  
Vol 96 (6) ◽  
pp. 704-712 ◽  
Author(s):  
R L O’Connor-Semmes ◽  
J Lin ◽  
R J Hodge ◽  
S Andrews ◽  
J Chism ◽  
...  
Keyword(s):  
Systemic Exposure ◽  
Binding Domain ◽  
Albumin Binding ◽  
Domain Antibody

Biodistribution of a 67Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag)

2014 ◽  
Vol 41 ◽  
pp. e44-e48 ◽  
Author(s):  
Maurício Morais ◽  
Cátia Cantante ◽  
Lurdes Gano ◽  
Isabel Santos ◽  
Sara Lourenço ◽  
...  
Keyword(s):  
Binding Domain ◽  
Single Domain ◽  
Albumin Binding ◽  
Single Domain Antibody ◽  
Domain Antibody

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice

1999 ◽  
Vol 88 (12) ◽  
pp. 1281-1287 ◽  
Author(s):  
Masami Kawahara ◽  
Atsushi Sakata ◽  
Toshiaki Miyashita ◽  
Ikumi Tamai ◽  
Akira Tsuji
Keyword(s):  
Knockout Mice ◽  
Physiologically Based Pharmacokinetics ◽  
Physiologically Based

Display of the Albumin-Binding Domain in the Envelope Improves Lentiviral Vector Bioavailability

2017 ◽  
Vol 28 (6) ◽  
pp. 340-351 ◽  
Author(s):  
Guillermo Garaulet ◽  
Juan José Lazcano ◽  
Hernán Alarcón ◽  
Sergio de Frutos ◽  
Jorge Luis Martínez-Torrecuadrada ◽  
...  
Keyword(s):  
Lentiviral Vector ◽  
Binding Domain ◽  
Albumin Binding

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

10.3791/62488 ◽  
2021 ◽  
Author(s):  
Reza Rezaei ◽  
Abera Surendran ◽  
Ragunath Singaravelu ◽  
Taylor R. Jamieson ◽  
Parisa Taklifi ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Binding Domain ◽  
Receptor Binding Domain ◽  
Domain Antibody
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