Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

Kenneth W. Witwer; Bas W.M. Van Balkom; Stefania Bruno; Andre Choo; Massimo Dominici; Mario Gimona; Andrew F. Hill; Dominique De Kleijn; Mickey Koh; Ruenn Chai Lai; S. Alex Mitsialis; Luis A. Ortiz; Eva Rohde; Takashi Asada; Wei Seong Toh; Daniel J. Weiss; Lei Zheng; Bernd Giebel; Sai Kiang Lim

doi:10.1080/20013078.2019.1609206

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

Journal of Extracellular Vesicles ◽

10.1080/20013078.2019.1609206 ◽

2019 ◽

Vol 8 (1) ◽

pp. 1609206 ◽

Cited By ~ 78

Author(s):

Kenneth W. Witwer ◽

Bas W.M. Van Balkom ◽

Stefania Bruno ◽

Andre Choo ◽

Massimo Dominici ◽

...

Keyword(s):

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Therapeutic Applications

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Faculty Opinions recommendation of Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735736677.793570943 ◽

2020 ◽

Author(s):

Karen Bieback

Keyword(s):

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Therapeutic Applications

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Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles

Cytotherapy ◽

10.1016/j.jcyt.2021.01.001 ◽

2021 ◽

Author(s):

Mario Gimona ◽

Maria Felice Brizzi ◽

Andre Boon Hwa Choo ◽

Massimo Dominici ◽

Sean M. Davidson ◽

...

Keyword(s):

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Therapeutic Applications

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Faculty Opinions recommendation of Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726337894.793525804 ◽

2016 ◽

Author(s):

Jakub Tolar ◽

Bethany Hart

Keyword(s):

Radiation Damage ◽

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Hematopoietic Cells

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Mesenchymal Stromal Cell‐derived Extracellular Vesicles in Preclinical Animal Models of Tumor Growth: Systematic Review and Meta‐analysis

Stem Cell Reviews and Reports ◽

10.1007/s12015-021-10163-5 ◽

2021 ◽

Author(s):

Adrian J.M. Bailey ◽

Alvin Tieu ◽

Manika Gupta ◽

Mitchell Slobodian ◽

Risa Shorr ◽

...

Keyword(s):

Systematic Review ◽

Animal Models ◽

Tumor Growth ◽

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Meta Analysis ◽

Preclinical Animal Models

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A Good Manufacturing Practice–grade standard protocol for exclusively human mesenchymal stromal cell–derived extracellular vesicles

Cytotherapy ◽

10.1016/j.jcyt.2017.01.001 ◽

2017 ◽

Vol 19 (4) ◽

pp. 458-472 ◽

Cited By ~ 66

Author(s):

Karin Pachler ◽

Thomas Lener ◽

Doris Streif ◽

Zsuzsanna A. Dunai ◽

Alexandre Desgeorges ◽

...

Keyword(s):

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Good Manufacturing Practice ◽

Standard Protocol

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Mesenchymal stromal cell-derived small extracellular vesicles promote angio-osteogenesis and modulate macrophage polarization to enhance bone regeneration

Cytotherapy ◽

10.1016/s1465324921004473 ◽

2021 ◽

Vol 23 (5) ◽

pp. S111

Author(s):

S. Chuah ◽

C. Yong ◽

J. Chew ◽

Y. Cheow ◽

K. Teo ◽

...

Keyword(s):

Bone Regeneration ◽

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Macrophage Polarization

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Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of Mesenchymal Stromal Cell (MSC)-derived soluble proteins and Extracellular Vesicles (EVs)

Biomaterials ◽

10.1016/j.biomaterials.2020.120633 ◽

2020 ◽

pp. 120633

Author(s):

Cansu Gorgun ◽

Davide Ceresa ◽

Raphaelle Lesage ◽

Federico Villa ◽

Daniele Reverberi ◽

...

Keyword(s):

Extracellular Vesicles ◽

Inflammatory Cytokines ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Soluble Proteins ◽

Angiogenic Potential

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Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites

Journal of Cellular and Molecular Medicine ◽

10.1111/jcmm.17112 ◽

2021 ◽

Author(s):

Yvan Courageux ◽

Marta Monguió‐Tortajada ◽

Cristina Prat‐Vidal ◽

Antoni Bayes‐Genis ◽

Santiago Roura

Keyword(s):

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Clinical Translation ◽

Scientific Rationale

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Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2020.553444 ◽

2020 ◽

Vol 8 ◽

Cited By ~ 1

Author(s):

Miguel de Almeida Fuzeta ◽

Nuno Bernardes ◽

Filipa D. Oliveira ◽

Ana Catarina Costa ◽

Ana Fernandes-Platzgummer ◽

...

Keyword(s):

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Culture System ◽

Stromal Cell ◽

Bioreactor Culture ◽

Scalable Production

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Mesenchymal stromal cell‐derived extracellular vesicles for regenerative therapy and immune modulation: Progress and challenges toward clinical application

Stem Cells Translational Medicine ◽

10.1002/sctm.19-0114 ◽

2019 ◽

Vol 9 (1) ◽

pp. 39-46 ◽

Cited By ~ 10

Author(s):

David Allan ◽

Alvin Tieu ◽

Manoj Lalu ◽

Dylan Burger

Keyword(s):

Clinical Application ◽

Extracellular Vesicles ◽

Mesenchymal Stromal Cell ◽

Immune Modulation ◽

Stromal Cell ◽

Regenerative Therapy

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