Mesenchymal Stromal Cell‐derived Extracellular Vesicles in Preclinical Animal Models of Tumor Growth: Systematic Review and Meta‐analysis

2021 ◽  
Author(s):  
Adrian J.M. Bailey ◽  
Alvin Tieu ◽  
Manika Gupta ◽  
Mitchell Slobodian ◽  
Risa Shorr ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Tumor Growth ◽  
Extracellular Vesicles ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Meta Analysis ◽  
Preclinical Animal Models

scholarly journals Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147170 ◽  
Author(s):  
Lauralyn A. McIntyre ◽  
David Moher ◽  
Dean A. Fergusson ◽  
Katrina J. Sullivan ◽  
Shirley H. J. Mei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Cell Therapy ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Preclinical Animal Models

scholarly journals MSC-Derived Extracellular Vesicles in Preclinical Animal Models of Bone Injury: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 27 (3) ◽  
pp. S191
Author(s):  
Aidan Kirkham ◽  
Adrian Bailey ◽  
Alvin Tieu ◽  
Harinad Maganti ◽  
Joshua Montroy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Extracellular Vesicles ◽  
Meta Analysis ◽  
Bone Injury ◽  
Preclinical Animal Models

MSC-Derived Extracellular Vesicles in Preclinical Animal Models of Bone Injury: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Aidan M. Kirkham ◽  
Adrian J. M. Bailey ◽  
Alvin Tieu ◽  
Harinad B. Maganti ◽  
Joshua Montroy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Extracellular Vesicles ◽  
Meta Analysis ◽  
Bone Injury ◽  
Preclinical Animal Models

scholarly journals Effects of mesenchymal stromal cell-conditioned media on measures of lung structure and function: a systematic review and meta-analysis of preclinical studies

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alvaro Moreira ◽  
Rija Naqvi ◽  
Kristen Hall ◽  
Chimobi Emukah ◽  
John Martinez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Lung Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Lung ◽  
Meta Analysis ◽  
Structure And Function ◽  
Lung Structure ◽  
And Function

Abstract Background Lung disease is a leading cause of morbidity and mortality. A breach in the lung alveolar-epithelial barrier and impairment in lung function are hallmarks of acute and chronic pulmonary illness. This review is part two of our previous work. In part 1, we demonstrated that CdM is as effective as MSCs in modulating inflammation. Herein, we investigated the effects of mesenchymal stromal cell (MSC)-conditioned media (CdM) on (i) lung architecture/function in animal models mimicking human lung disease, and (ii) performed a head-to-head comparison of CdM to MSCs. Methods Adhering to the animal Systematic Review Centre for Laboratory animal Experimentation protocol, we conducted a search of English articles in five medical databases. Two independent investigators collected information regarding lung: alveolarization, vasculogenesis, permeability, histologic injury, compliance, and measures of right ventricular hypertrophy and right pulmonary pressure. Meta-analysis was performed to generate random effect size using standardized mean difference with 95% confidence interval. Results A total of 29 studies met inclusion. Lung diseases included bronchopulmonary dysplasia, asthma, pulmonary hypertension, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis. CdM improved all measures of lung structure and function. Moreover, no statistical difference was observed in any of the lung measures between MSCs and CdM. Conclusions In this meta-analysis of animal models recapitulating human lung disease, CdM improved lung structure and function and had an effect size comparable to MSCs.

Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis

2016 ◽  
Vol 3 (1) ◽  
pp. e45-e52 ◽  
Author(s):  
Shahrukh Hashmi ◽  
Mohammad Ahmed ◽  
M Hassan Murad ◽  
Mark R Litzow ◽  
Roberta H Adams ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cell Therapy ◽  
Graft Versus Host Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Meta Analysis ◽  
Host Disease ◽  
Graft Versus Host ◽  
Steroid Refractory ◽  
Acute Graft

scholarly journals Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Alvin Tieu ◽  
Mitchell Slobodian ◽  
Dean A. Fergusson ◽  
Joshua Montroy ◽  
Dylan Burger ◽  
...  
Keyword(s):  
Systematic Review ◽  
Extracellular Vesicles ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Extracellular Vesicle ◽  
Preclinical Studies ◽  
Tissue Source ◽  
Models Of Disease

Abstract Background Over the past decade, mesenchymal stromal cells have been increasingly investigated for their therapeutic potential in several different illnesses. However, cell therapy can be limited by potentially serious adverse events including cell embolus formation and tumorigenesis. Importantly, the protective effects of mesenchymal stromal cells are largely mediated by paracrine mechanisms including release of extracellular vesicles. This systematic review intends to synthesize the current knowledge of mesenchymal stromal cell-derived extracellular vesicles as a therapeutic option for preclinical models of disease, inflammation, or injury. Methods A systematic literature search of MEDLINE, Embase, and BIOSIS databases will be conducted. Interventional preclinical in vivo studies using extracellular vesicles derived from any tissue source of mesenchymal stromal cells will be included. Studies will be screened by abstract, and full-text by two independent reviewers. Eligible studies will undergo data extraction with subcategorization into domains based on disease. Methods utilized for extracellular vesicle characterization and isolation will be collected, as well as information on interventional traits, such as tissue source of mesenchymal stromal cells, dosage regimen, and vesicle modifications. Reported outcomes will be collected to determine which diseases studied may be impacted most from treatment with mesenchymal stromal cell-derived extracellular vesicles. Discussion This systematic review will summarize preclinical studies investigating the therapeutic efficacy of both small and large extracellular vesicles derived by mesenchymal stromal cells. Extracellular vesicles represent a possibility to harness the benefits of mesenchymal stromal cells with added benefits of reduced manufacturing costs and an improved safety profile. Hence, there has been an exponential increase in interest for developing this cell-free therapy with hundreds of preclinical studies published to date. However, a vast amount of heterogeneity between groups relates to methods of extracellular vesicle isolation, characterization, and study design. This review will capture this heterogeneity and identify the most commonly used and optimal approaches to evaluate mesenchymal stromal cell-derived extracellular vesicle treatment. A meta-analysis of outcomes within each disease domain will help elucidate which fields of research demonstrate promise for developing extracellular vesicles as a novel cell-free therapy. Summarizing this robust information on extracellular vesicles as an intervention can provide guidance for designing preclinical studies with hopes of future clinical translation.

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