QbD Driven Development and Validation of UV Spectrophotometric Method for Estimation of Paliperidone in Extended Release Tablet Dosage Form

2018 ◽  
Vol 8 (4) ◽  
pp. 510-518
Author(s):  
Sagar Suman Panda ◽  
Jagrutirani Rath ◽  
Venkata Varaha Ravi Kumar Bera
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Extended Release ◽  
Development And Validation ◽  
Tablet Dosage ◽  
Extended Release Tablet ◽  
Release Tablet

Once-daily propranolol extended-release tablet dosage form: formulation design and in vitro/in vivo investigation

2004 ◽  
Vol 58 (3) ◽  
pp. 607-614 ◽  
Author(s):  
Yaw-Bin Huang ◽  
Yi-Hung Tsai ◽  
Wan-Chiech Yang ◽  
Jui-Sheng Chang ◽  
Pao-Chu Wu ◽  
...  
Keyword(s):  
Dosage Form ◽  
Extended Release ◽  
Formulation Design ◽  
Once Daily ◽  
Tablet Dosage ◽  
Extended Release Tablet ◽  
Release Tablet

scholarly journals Formulation of Extended-Release Ranolazine Tablet and Investigation Its Stability in the Accelerated Stability Condition At 40⁰C And 75 % Humidity

2021 ◽  
pp. 1-3
Author(s):  
Farzad Khajavi ◽  
Keyword(s):  
Stability Condition ◽  
Dosage Form ◽  
Extended Release ◽  
Chemical Characteristics ◽  
Physical And Chemical Characteristics ◽  
Eudragit L100 ◽  
Accelerated Stability ◽  
Physical And Chemical ◽  
Extended Release Tablet ◽  
Release Tablet

Formulation of Ranolazine in the form of extended-release tablet in 500 mg dosage form was performed using Eudragit L100-55 as a retarding agent. Drugrelease profiles were investigated in comparison with the reference Ranexa extended-release 500 mg tablet. F2 and f1 were calculated as 64.16 and 8.53, respectively. According to Peppas equation, the release of drug is controlled by diffusion (n=0.5). The tablets were put into accelerated stability condition (40⁰C, 75% humidity) for 3 and 6 months. The dissolution release profiles and other physical and chemical characteristics of the tablets confirmed the robustness and stability of formulation in this condition.

scholarly journals Development DEVELOPMENT AND VALIDATION OF NOVEL ULTRAVIOLET SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE ESTIMATION OF DALFAMPRIDINE IN BULK AND IN PHARMACEUTICAL FORMULATION

2019 ◽  
pp. 275-279
Author(s):  
VAIBHAV S KHODKE ◽  
GAME MD
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Quantitative Estimation ◽  
Spectroscopic Method ◽  
Quality Criteria ◽  
Pharmaceutical Dosage Form ◽  
Development And Validation ◽  
Tablet Dosage ◽  
Good Agreement

Objective: The objective of the present study is to develop ultraviolet (UV)-spectroscopic method using pure drug and tablet dosage form that consistently produces a drug with a minimal variation that adheres to quality criteria of purity, identity, and potency. Methods: UV-spectrophotometric method has been developed using a solvent composed of methanol:water (30:70) as a diluent to determine the dalfampridine (DFP) content in bulk and pharmaceutical dosage form at predetermined λmax of 262 nm. Results: It was proved linear in the range of 02–12 μg/ml and exhibited a good correlation coefficient (r2 = 0.9915) and excellent mean recovery (0.004136347%). This method was successfully applied to the determination of DFP content of marketed tablet Dalstep 10 mg (Sun Pharmaceutical Pvt. Ltd.,) from India; the results were in good agreement with the label claims. Conclusion: The method proved to be simple, accurate, precise, specific, robust, and less time consuming and can be applied for the determination of DFP in bulk and marketed formulation.

scholarly journals Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method

2012 ◽  
Vol 2 (4) ◽  
pp. 306-309 ◽  
Author(s):  
Prajesh Prajapati ◽  
Vipul Vaghela ◽  
Deepak Rawtani ◽  
Harshad Patel ◽  
Jasmin Kubavat ◽  
...  
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Azeotropic Mixture ◽  
Development And Validation ◽  
Tablet Dosage
Sign in / Sign up

Export Citation Format

Share Document