This is the second of three chapters serving as the introduction to this handbook which addresses the relationship between human cognition and assistive technologies and its design for individuals with cognitive disabilities. In this chapter the authors present strategies to manage cognitive load in the design of instructional materials for those with learning disabilities. The authors introduce cognitive load theory, which proposes a set of instructional principles grounded in human information processing research that can be leveraged in the creation of efficient and effective learning environments. They attempt to separate conjecture and speculation from empirically-based study and consolidate more than twenty-five years of research to highlight the best ways in which to increase learning. Altogether, the authors affirm the approach discussed in the last chapter—that technology for learning should be created with an understanding of design principles empirically supported by how the human mind works, particularly when it comes to the design of assistive technologies for individuals with learning disabilities.