Polycystic ovary syndrome: relationship between insulin sensitivity, sex hormone levels and ovarian stromal blood flow

2001 ◽  
Vol 15 (2) ◽  
pp. 142-149 ◽  
Author(s):  
G. Loverro ◽  
M. Vicino ◽  
F. Lorusso ◽  
A. Vimercati ◽  
P. Greco ◽  
...  
Keyword(s):  
Blood Flow ◽  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Ovary Syndrome ◽  
Hormone Levels

Polycystic ovary syndrome: relationship between insulin sensitivity ,sex hormone levels and ovarian stromal blood flow

2001 ◽  
Vol 15 (2) ◽  
pp. 142-149 ◽  
Author(s):  
G. Loverro ◽  
M. Vicino ◽  
F. Lorusso ◽  
A. Vimercati ◽  
P. Greco ◽  
...  
Keyword(s):  
Blood Flow ◽  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Ovary Syndrome ◽  
Hormone Levels

SEX HORMONE LEVELS AND GONADOTROPHIN RELEASE IN THE POLYCYSTIC OVARY SYNDROME

1975 ◽  
Vol 4 (3) ◽  
pp. 287-295 ◽  
Author(s):  
N. M. DUIGNAN ◽  
R. W. SHAW ◽  
B. T. RUDD ◽  
G. HOLDER ◽  
J. W. WILLIAMS ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Ovary Syndrome ◽  
Hormone Levels

scholarly journals Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome

2004 ◽  
pp. 215-223 ◽  
Author(s):  
J Vrbikova ◽  
S Stanicka ◽  
K Dvorakova ◽  
M Hill ◽  
K Vondra ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Cyproterone Acetate ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Sex Hormone ◽  
Disposition Index ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovary Syndrome

OBJECTIVE: To compare the influence of transdermal and peroral oestrogen treatments in conjunction with cyproterone acetate (CPA) on metabolic and hormonal parameters in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: Twenty-four women with PCOS, aged 25.4+/-4.3 (mean+/-s.d.) years, body mass index 24.5+/-3.9 kg/m2 were randomly assigned to receive either transdermal oestradiol plus CPA (n=12) or a peroral oestradiol-CPA combination (n=12). Before and after 3 months of treatment, basal blood samples, euglycaemic hyperinsulinaemic clamp combined with indirect calorimetry and arginine tests were performed. ANOVA and Student's t-test or Wilcoxon's test were used for statistical analyses. RESULTS: After peroral oestradiol-CPA, insulin sensitivity (P<0.004) and the disposition index as the function of insulin sensitivity and secretion (P<0.0001) decreased significantly. Fasting insulin (P<0.05), cholesterol (P<0.05), high-density lipoprotein cholesterol (P<0.05) and sex-hormone binding globulin (P<0.0001) increased significantly. Dehydroepiandrosterone (P<0.05) and 17-OH progesterone (P<0.01) decreased significantly. After transdermal oestradiol+CPA, no significant changes were observed in sex-hormone binding globulin and androgen concentrations, insulin sensitivity or disposition index. CONCLUSIONS: In women with PCOS, peroral oestrogens (at doses common in combined oral contraceptives) led to a significant impairment in insulin secretion and action. In contrast, the transdermal application of oestrogens did not significantly influence insulin sensitivity.

Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome

1997 ◽  
Vol 11 (5) ◽  
pp. 315-320 ◽  
Author(s):  
D. Micić ◽  
Dj. Macut ◽  
V. Popović ◽  
M. Ŝumarac-Dumanović ◽  
A. Kendereŝki ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Patients ◽  
Ovary Syndrome
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