FLAVINDOGENIDES AS 2π COMPONENT IN 1,3-DIPOLAR CYCLOADDITION REACTION—AN EFFICIENT SYNTHESIS OF NEW CLASS OF DISPIROHETEROCYCLES

2002 ◽  
Vol 32 (23) ◽  
pp. 3587-3594 ◽  
Author(s):  
S. Manikandan ◽  
R. Raghunathan
Keyword(s):  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Efficient Synthesis ◽  
New Class

scholarly journals Efficient synthesis of some new antiproliferative N-fused indoles and isoquinolines via 1,3-dipolar cycloaddition reaction in an ionic liquid

2015 ◽  
Vol 39 (4) ◽  
pp. 2657-2668 ◽  
Author(s):  
Tushar R. Sutariya ◽  
Balvantsingh M. Labana ◽  
Narsidas J. Parmar ◽  
Rajni Kant ◽  
Vivek K. Gupta ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Cycloaddition Reaction ◽  
Reaction Medium ◽  
Environmentally Friendly ◽  
Dipolar Cycloaddition ◽  
Efficient Synthesis ◽  
Triethylammonium Acetate

Triethylammonium acetate (TEAA) as a new, recyclable and environmentally friendly reaction medium for the intramolecular[3+2] cycloaddition reaction.

Highly enantioselective catalytic 1,3-dipolar cycloadditions of α-alkyl diazoacetates: efficient synthesis of functionalized 2-pyrazolines

2015 ◽  
Vol 13 (9) ◽  
pp. 2745-2749 ◽  
Author(s):  
Sung Il Lee ◽  
Ka Eun Kim ◽  
Geum-Sook Hwang ◽  
Do Hyun Ryu
Keyword(s):  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Efficient Synthesis ◽  
Dipolar Cycloadditions

Chiral oxazaborolidinium ion catalyzed 1,3-dipolar cycloaddition reaction of α-substituted diazoacetates gives functionalized 2-pyrazolines in high to excellent enantiomeric ratios.

ChemInform Abstract: Efficient Synthesis of Some New Antiproliferative N-Fused Indoles and Isoquinolines via 1,3-Dipolar Cycloaddition Reaction in an Ionic Liquid.

ChemInform ◽  
2015 ◽  
Vol 46 (33) ◽  
pp. no-no
Author(s):  
Tushar R. Sutariya ◽  
Balvantsingh M. Labana ◽  
Narsidas J. Parmar ◽  
Rajni Kant ◽  
Vivek K. Gupta ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Efficient Synthesis

scholarly journals Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4671
Author(s):  
Assem Barakat ◽  
Saeed Alshahrani ◽  
Abdullah Mohammed Al-Majid ◽  
M. Ali ◽  
Mezna Saleh Altowyan ◽  
...  
Keyword(s):  
Cycloaddition Reaction ◽  
Acetylcholinesterase Inhibitors ◽  
Docking Studies ◽  
Dipolar Cycloaddition ◽  
Stacking Interactions ◽  
Anionic Sites ◽  
Active Analog ◽  
New Class ◽  
Ic50 Value ◽  
Ache Inhibitory Activity

A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated. All the synthesized compounds exhibited moderate inhibitory activities against AChE, while IIc was found to be the most active analog with an IC50 value of 20,840 µM·L−1. Its molecular structure was a 5-chloro-substituted oxindole bearing benzo[b]thiophene and octahydroindole moieties. Based on molecular docking studies, IIc was strongly bound to the catalytic and peripheral anionic sites of the protein through hydrophilic, hydrophobic, and π-stacking interactions with Asp74, Trp86, Tyr124, Ser125, Glu202, Ser203, Trp236, Trp286, Phe297, Tyr337, and Tyr341. These interactions also indicated that the multiplicity of the IIc aromatic core significantly favored its activity.

An experimental and theoretical study on the regioselective synthesis of a new class of spiropyrrolothiazoles with quinoxaline motifs via a 1,3-dipolar cycloaddition reaction. An evaluation of DFT methods

RSC Advances ◽  
2015 ◽  
Vol 5 (93) ◽  
pp. 76368-76376 ◽  
Author(s):  
Mahshid Hamzehloueian ◽  
Yaghoub Sarrafi ◽  
Zahra Aghaei
Keyword(s):  
Theoretical Study ◽  
Cycloaddition Reaction ◽  
Regioselective Synthesis ◽  
Dipolar Cycloaddition ◽  
Cycloaddition Reactions ◽  
Dft Methods ◽  
Π Interactions ◽  
New Class

Evaluation of B3LYP/6-31G(d,p), wB97xD/6-31G(d,p) and M06-2X/6-31G(d,p) methods revealed the importance of π/π interactions in regio- and stereoselectivity of cycloaddition reactions.

A facile and efficient synthesis of polycyclic spiropyrrolidine oxindoles bearing mesityl oxide unit via a three-component 1,3-dipolar cycloaddition reaction

Tetrahedron ◽  
2015 ◽  
Vol 71 (42) ◽  
pp. 8131-8139 ◽  
Author(s):  
Hui-Juan Wang ◽  
Bo-Wen Pan ◽  
Wen-Hui Zhang ◽  
Chao Yang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Cycloaddition Reaction ◽  
Mesityl Oxide ◽  
Dipolar Cycloaddition ◽  
Efficient Synthesis
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