A J-protein is an essential subunit of the presequence translocase–associated protein import motor of mitochondria
2003 ◽
Vol 163
(4)
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pp. 707-713
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Keyword(s):
Transport of preproteins into the mitochondrial matrix is mediated by the presequence translocase–associated motor (PAM). Three essential subunits of the motor are known: mitochondrial Hsp70 (mtHsp70); the peripheral membrane protein Tim44; and the nucleotide exchange factor Mge1. We have identified the fourth essential subunit of the PAM, an essential inner membrane protein of 18 kD with a J-domain that stimulates the ATPase activity of mtHsp70. The novel J-protein (encoded by PAM18/YLR008c/TIM14) is required for the interaction of mtHsp70 with Tim44 and protein translocation into the matrix. We conclude that the reaction cycle of the PAM of mitochondria involves an essential J-protein.
2009 ◽
Vol 184
(1)
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pp. 129-141
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2005 ◽
Vol 25
(17)
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pp. 7449-7458
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2008 ◽
Vol 28
(13)
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pp. 4424-4433
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1994 ◽
Vol 127
(6)
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pp. 1547-1556
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Keyword(s):
2018 ◽
Vol 16
(1)
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pp. 64-73
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1997 ◽
Vol 272
(6)
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pp. H2983-H2988
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1999 ◽
Vol 274
(16)
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pp. 11275-11282
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Keyword(s):
Keyword(s):
1994 ◽
Vol 5
(5)
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pp. 529-538
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