MyoD-positive epiblast cells regulate skeletal muscle differentiation in the embryo
2006 ◽
Vol 175
(2)
◽
pp. 283-292
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MyoD mRNA is expressed in a subpopulation of cells within the embryonic epiblast. Most of these cells are incorporated into somites and synthesize Noggin. Ablation of MyoD-positive cells in the epiblast subsequently results in the herniation of organs through the ventral body wall, a decrease in the expression of Noggin, MyoD, Myf5, and myosin in the somites and limbs, and an increase in Pax-3–positive myogenic precursors. The addition of Noggin lateral to the somites compensates for the loss of MyoD-positive epiblast cells. Skeletal muscle stem cells that arise in the epiblast are utilized in the somites to promote muscle differentiation by serving as a source of Noggin.
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2012 ◽
Vol 2
(1)
◽
pp. 11-21
Keyword(s):
2012 ◽
Vol 2
(1)
◽
pp. 11-21
Keyword(s):