MAINTENANCE OF SKIN XENOGRAFTS OF WIDELY DIVERGENT PHYLOGENETIC ORIGIN ON CONGENITALLY ATHYMIC (NUDE) MICE

Congenitally athymic (nude) mice accepted for their lifetime intact skin grafts from distantly related mammals (cat, human) and birds (chicken). They also failed to immunologically reject skin grafts from reptiles (lizards) and amphibians (tree frog), although the skin in these grafts underwent varying degrees of disorganization. A definitive role for the thymic defect in this failure to reject xenografts was established by showing that thymus implantation into nude mice enabled them to reject such foreign skin.

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Pathology Produced by Sulfur Mustard in Human Skin Grafts on Athymic Nude Mice. II. Ultrastructural Changes

Journal of Toxicology Cutaneous and Ocular Toxicology ◽

10.3109/15569528409036290 ◽

1984 ◽

Vol 3 (4) ◽

pp. 393-408 ◽

Cited By ~ 67

Author(s):

Bruno Papirmeister ◽

Clark L. Gross ◽

John P. Petrali ◽

Henry L. Meier

Keyword(s):

Human Skin ◽

Nude Mice ◽

Sulfur Mustard ◽

Ultrastructural Changes ◽

Skin Grafts ◽

Athymic Nude Mice

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Pathology Produced by Sulfur Mustard in Human Skin Grafts on Athymic Nude Mice. I. Gross and Light Microscopic Changes

Journal of Toxicology Cutaneous and Ocular Toxicology ◽

10.3109/15569528409036289 ◽

1984 ◽

Vol 3 (4) ◽

pp. 371-391 ◽

Cited By ~ 39

Author(s):

Bruno Papimeisier ◽

Clark L. Gross ◽

John P. Petrali ◽

Clifford J. Hixson

Keyword(s):

Human Skin ◽

Nude Mice ◽

Sulfur Mustard ◽

Skin Grafts ◽

Athymic Nude Mice

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Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010005384x ◽

1982 ◽

Vol 40 ◽

pp. 236-237

Author(s):

E.C. Chew ◽

C.L. Li ◽

D.P. Huang ◽

H.C. Ho ◽

L.S. Mak ◽

...

Keyword(s):

Cell Line ◽

Nude Mice ◽

Biopsy Specimen ◽

Epithelial Cell Line ◽

Present Communication ◽

Recurrent Tumour ◽

Athymic Nude Mice ◽

Cell Line Establishment ◽

Fine Structures ◽

Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

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972: Antisense CK2 Gene Therapy Induces Regression in Human Bladder Cancer Growing in Athymic Nude Mice

The Journal of Urology ◽

10.1016/s0022-5347(18)38209-0 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 257-258

Author(s):

Joel Slaton ◽

Daniel Sloper ◽

Miriam Taylor ◽

Alan Davis ◽

Khalil Ahmed

Keyword(s):

Gene Therapy ◽

Bladder Cancer ◽

Nude Mice ◽

Human Bladder Cancer ◽

Human Bladder ◽

Athymic Nude Mice

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Integration of viral sequences into the c-myc gene in two mammary adenocarcinomas induced by polyomavirus in athymic nude mice.

Journal of Virology ◽

10.1128/jvi.69.10.5935-5945.1995 ◽

1995 ◽

Vol 69 (10) ◽

pp. 5935-5945 ◽

Cited By ~ 1

Author(s):

M Berebbi ◽

C Cajean-Feroldi ◽

F Apiou ◽

J Couturier ◽

M Garcette ◽

...

Keyword(s):

Nude Mice ◽

Athymic Nude Mice ◽

Myc Gene ◽

Viral Sequences ◽

Mammary Adenocarcinomas

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ELEVATED 1,25(OH)2D3 RECEPTORS IN SKIN OF ATHYMIC NUDE MICE

Vitamin D ◽

10.1515/9783110850345-031 ◽

1991 ◽

pp. 104-105

Keyword(s):

Nude Mice ◽

Athymic Nude Mice

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668 Fixation of Split-Thickness Skin Grafts with Liquid Adhesive and Fibrin Glue in Place of Staples

Journal of Burn Care & Research ◽

10.1093/jbcr/irab032.314 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

pp. S190-S191

Author(s):

Joshua Frost ◽

Nathan Hallier ◽

Tanir Moreno ◽

Jared Covell ◽

Ryan Keck ◽

...

Keyword(s):

Fibrin Glue ◽

Skin Grafting ◽

Skin Grafts ◽

Inclusion Criteria ◽

Intact Skin ◽

Body Area ◽

Wound Site ◽

Graft Take ◽

Thickness Skin ◽

Split Thickness Skin Grafting

Abstract Introduction A critical component of split-thickness skin grafting is the fixation of the skin graft to the wound site. Graft displacement can result in graft failure, especially during the initial 48–72 hours following application. The most common method of securing grafts is with the use of staples, sometimes with the addition of fibrin glue in order to aid both graft adhesion and homeostasis. The use of staples, however, is associated with significant levels of patient discomfort, especially during staple removal. A possible alternative to staples is the use of liquid adhesives, in combination with steri-strips, to anchor the edges of skin grafts to intact skin. Certain liquid adhesives, such as gum-based resins, are cheaper to use than staples and offer the potential to secure small split-thickness skin grafts without the associated pain of staples. In this pilot study, we examined the effectiveness of using a combination of gum-based resin (Gum Mastic-Storax-Msal-Alcohol), fibrin glue, and steri-strips to secure partial-thickness grafts in 8 patients without the use of staples or sutures. Methods Patients were included in the study who required split-thickness skin grafts to treat wounds involving less than or equal to 15% total surface body area and whose wounds were not located in areas prone to graft displacement, such as the axilla and groin. For each patient, skin grafts were secured using fibrin glue (sprayed over the entire wound), and a combination of liquid adhesive and steri-strips applied around the wound perimeter. The success of each graft was determined by the percentage of graft take. Results From January 1st, 2020 to April 30th, 2020, 8 patients were identified who fit the inclusion criteria. Five of the patients received grafts to their lower extremities, two patients received grafts to their upper extremities, and one of the patients received a graft to the torso. The average wound site that was grafted was 116.7 cm2. Average graft take among the 8 patients was 96.9%, with a range of 90%-100%. No complications at the graft site were noted, such as hematomas or any other event that resulted in graft displacement or failure. Conclusions The results of the study demonstrate that a combination of liquid adhesive, fibrin glue, and steri-strips, can be used as an effective alternative to staples in small split-thickness skin grafts. The use of liquid adhesive in place of staples was advantageous because it eliminated to need for staple removal, which resulted in less discomfort for the patient and less work for the nursing staff.

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