Essential Lymphocyte Function Associated 1 (LFA-1): Intercellular Adhesion Molecule Interactions for T Cell–mediated B Cell Apoptosis by Fas/APO-1/CD95
1997 ◽
Vol 186
(7)
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pp. 1171-1176
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B cells are susceptible to Fas ligand (FasL)+ CD4+ Th1 cell–mediated apoptosis. We demonstrate that blocking the interactions between lymphocyte function associated (LFA)-1 and intercellular adhesion molecule(ICAM)-1 and ICAM-2 completely suppresses Fas-dependent B cell lysis. Antibodies to CD2 and CD48 partially suppress B cell apoptosis, whereas anti-B7.1 and anti-B7.2 antibodies have no effect. Also, B cells from ICAM-1–deficient mice are resistant to FasL+ T cell–mediated death. Our results suggest that LFA-1/ICAM interactions are crucial for Th1 cell–mediated B cell apoptosis and may contribute to the maintenance of B cell homeostasis in vivo.
2002 ◽
Vol 43
(11)
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pp. 2071-2074
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1996 ◽
Vol 26
(1)
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pp. 192-200
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1990 ◽
Vol 48
(3)
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pp. 378-379
1994 ◽
Vol 179
(1)
◽
pp. 359-363
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2021 ◽
1992 ◽
Vol 5
(1)
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pp. 119-135
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