scholarly journals Nitric Oxide Primes Pancreatic β Cells for Fas-mediated Destruction in Insulin-dependent Diabetes Mellitus

1997 ◽  
Vol 186 (8) ◽  
pp. 1193-1200 ◽  
Author(s):  
Giorgio Stassi ◽  
Ruggero De Maria ◽  
Giuliana Trucco ◽  
William Rudert ◽  
Roberto Testi ◽  
...  

Fas is an apoptosis-inducing surface receptor involved in controlling tissue homeostasis and function at multiple sites. Here we show that β cells from the pancreata of newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients express Fas and show extensive apoptosis among those cells located in proximity to Fas ligand–expressing T lymphocytes infiltrating the IDDM islets. Normal human pancreatic β cells that do not constitutively express Fas, become strongly Fas positive after interleuken (IL)-1β exposure, and are then susceptible to Fas-mediated apoptosis. NG-monomethyl-l-arginine, an inhibitor of nitric oxide (NO) synthase, prevents IL-1β–induced Fas expression, whereas the NO donors sodium nitroprusside and nitric oxide releasing compound (NOC)-18, induce functional Fas expression in normal pancreatic β cells. These findings suggest that NO-mediated upregulation of Fas contributes to pancreatic β cell damage in IDDM.

1996 ◽  
Vol 27 (3) ◽  
pp. 567-574 ◽  
Author(s):  
Stephen B. Williams ◽  
Jorge A. Cusco ◽  
Mary-Anne Roddy ◽  
Michael T. Johnstone ◽  
Mark A. Creager

Diabetologia ◽  
1993 ◽  
Vol 36 (1) ◽  
pp. 33-38 ◽  
Author(s):  
G. E. McVeigh ◽  
G. M. Brennan ◽  
G. D. Johnston ◽  
B. J. McDermott ◽  
L. T. McGrath ◽  
...  

1997 ◽  
Vol 134 (1-2) ◽  
pp. 305
Author(s):  
A. Avogaro ◽  
S. Del Prato ◽  
F. Piarulli ◽  
L. Calò ◽  
M. Miola ◽  
...  

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