Vaccination with Minigenes Encoding VH-derived Major Histocompatibility Complex Class I–binding Epitopes Activates Cytotoxic T Cells that Ablate Autoantibody-producing B Cells and Inhibit Lupus
2002 ◽
Vol 196
(6)
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pp. 731-741
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Current treatments for autoantibody-mediated diseases, such as lupus, can cause nonspecific immune suppression. In this paper, we used a bioinformatic approach to identify major histocompatibility complex class I–binding epitopes in the heavy chain variable region of anti-DNA antibodies from lupus-prone (NZB/NZW F1) mice. Vaccination of such mice with plasmid DNA vectors encoding these epitopes induced CD8+ T cells that killed anti-DNA antibody-producing B cells, reduced serum anti-DNA antibody levels, retarded the development of nephritis, and improved survival. Vaccine-mediated induction of anti-VH cytotoxic T lymphocytes that ablate autoreactive B cells represents a novel approach to treat autoantibody-mediated diseases.
1993 ◽
Vol 23
(12)
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pp. 3115-3119
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1993 ◽
Vol 90
(7)
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pp. 2676-2680
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2003 ◽
Vol 58
(2)
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pp. 211-220
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1989 ◽
Vol 86
(3)
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pp. 1018-1022
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1993 ◽
Vol 177
(6)
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pp. 1713-1721
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1998 ◽
Vol 66
(5)
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pp. 646-650
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