scholarly journals The route of priming influences the ability of respiratory virus–specific memory CD8+ T cells to be activated by residual antigen

2010 ◽  
Vol 207 (6) ◽  
pp. 1153-1160 ◽  
Author(s):  
Shiki Takamura ◽  
Alan D. Roberts ◽  
Dawn M. Jelley-Gibbs ◽  
Susan T. Wittmer ◽  
Jacob E. Kohlmeier ◽  
...  

After respiratory virus infections, memory CD8+ T cells are maintained in the lung airways by a process of continual recruitment. Previous studies have suggested that this process is controlled, at least in the initial weeks after virus clearance, by residual antigen in the lung-draining mediastinal lymph nodes (MLNs). We used mouse models of influenza and parainfluenza virus infection to show that intranasally (i.n.) primed memory CD8+ T cells possess a unique ability to be reactivated by residual antigen in the MLN compared with intraperitoneally (i.p.) primed CD8+ T cells, resulting in the preferential recruitment of i.n.-primed memory CD8+ T cells to the lung airways. Furthermore, we demonstrate that the inability of i.p.-primed memory CD8+ T cells to access residual antigen can be corrected by a subsequent i.n. virus infection. Thus, two independent factors, initial CD8+ T cell priming in the MLN and prolonged presentation of residual antigen in the MLN, are required to maintain large numbers of antigen-specific memory CD8+ T cells in the lung airways.

2003 ◽  
Vol 170 (3) ◽  
pp. 1423-1429 ◽  
Author(s):  
Kenneth H. Ely ◽  
Linda S. Cauley ◽  
Alan D. Roberts ◽  
Jean W. Brennan ◽  
Tres Cookenham ◽  
...  

2019 ◽  
Vol 216 (12) ◽  
pp. 2736-2747 ◽  
Author(s):  
Shiki Takamura ◽  
Shigeki Kato ◽  
Chihiro Motozono ◽  
Takeshi Shimaoka ◽  
Satoshi Ueha ◽  
...  

Populations of CD8+ lung-resident memory T (TRM) cells persist in the interstitium and epithelium (airways) following recovery from respiratory virus infections. While it is clear that CD8+ TRM cells in the airways are dynamically maintained via the continuous recruitment of new cells, there is a vigorous debate about whether tissue-circulating effector memory T (TEM) cells are the source of these newly recruited cells. Here we definitively demonstrate that CD8+ TRM cells in the lung airways are not derived from TEM cells in the circulation, but are seeded continuously by TRM cells from the lung interstitium. This process is driven by CXCR6 that is expressed uniquely on TRM cells but not TEM cells. We further demonstrate that the lung interstitium CD8+ TRM cell population is also maintained independently of TEM cells via a homeostatic proliferation mechanism. Taken together, these data show that lung memory CD8+ TRM cells in the lung interstitium and airways are compartmentally separated from TEM cells and clarify the mechanisms underlying their maintenance.


Immunity ◽  
2010 ◽  
Vol 33 (1) ◽  
pp. 96-105 ◽  
Author(s):  
Jacob E. Kohlmeier ◽  
Tres Cookenham ◽  
Alan D. Roberts ◽  
Shannon C. Miller ◽  
David L. Woodland

2001 ◽  
Vol 166 (3) ◽  
pp. 1813-1822 ◽  
Author(s):  
Robert J. Hogan ◽  
Edward J. Usherwood ◽  
Weimin Zhong ◽  
Alan D. Roberts ◽  
Richard W. Dutton ◽  
...  

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