scholarly journals Bhlhe40: Gatekeeper of the GC

2021 ◽  
Vol 219 (2) ◽  
Author(s):  
Stephen L. Nutt ◽  
Julie Tellier
Keyword(s):  
B Cells ◽  
Germinal Center ◽  
T Follicular Helper Cells ◽  
High Affinity ◽  
Helper Cells ◽  
Follicular Helper

The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211406) report that Bhlhe40 restrains GC output through distinct regulatory roles in both arms of the response.

scholarly journals Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations

2020 ◽  
Vol 479 ◽  
pp. 112746 ◽  
Author(s):  
Colin Havenar-Daughton ◽  
Isabel G. Newton ◽  
Somaye Y. Zare ◽  
Samantha M. Reiss ◽  
Brittany Schwan ◽  
...  
Keyword(s):  
Lymph Node ◽  
B Cells ◽  
Germinal Center ◽  
T Follicular Helper Cells ◽  
Fine Needle ◽  
Helper Cells ◽  
Follicular Helper ◽  
Human Lymph Node ◽  
Normal Human ◽  
Germinal Center B Cells

scholarly journals Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Blood ◽  
2014 ◽  
Vol 123 (25) ◽  
pp. 3988-3998 ◽  
Author(s):  
Ryan Flynn ◽  
Jing Du ◽  
Rachelle G. Veenstra ◽  
Dawn K. Reichenbach ◽  
Angela Panoskaltsis-Mortari ◽  
...  
Keyword(s):  
B Cells ◽  
Murine Model ◽  
Germinal Center ◽  
Bronchiolitis Obliterans ◽  
T Follicular Helper Cells ◽  
Novel Therapeutics ◽  
Helper Cells ◽  
Follicular Helper ◽  
Key Points ◽  
Germinal Center B Cells

Key Points T follicular helper cells and germinal center B cells are increased and strongly correlate with the development of cGVHD in a murine model. Blocking mAbs for IL-21, ICOS, and CD40L are potential novel therapeutics for cGVHD.

SS1-7 IL-27 supports germinal center function through combined effects on T follicular helper cells and B cells

Cytokine ◽  
2010 ◽  
Vol 52 (1-2) ◽  
pp. 12
Author(s):  
Marcel Batten ◽  
Nandhini Ramamoorthi ◽  
Noelyn Kljavin ◽  
Nico Ghilardi
Keyword(s):  
B Cells ◽  
Germinal Center ◽  
Combined Effects ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper

scholarly journals The Role of CD4+ T Follicular Helper Cells in HIV Infection: From the Germinal Center to the Periphery

2017 ◽  
Vol 8 ◽  
Author(s):  
John Patrick Thornhill ◽  
Sarah Fidler ◽  
Paul Klenerman ◽  
John Frater ◽  
Chansavath Phetsouphanh
Keyword(s):  
Hiv Infection ◽  
Germinal Center ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper

scholarly journals Germinal Center Alloantibody Responses Are Mediated Exclusively by Indirect-Pathway CD4 T Follicular Helper Cells

2012 ◽  
Vol 188 (6) ◽  
pp. 2643-2652 ◽  
Author(s):  
Thomas M. Conlon ◽  
Kourosh Saeb-Parsy ◽  
Jennifer L. Cole ◽  
Reza Motallebzadeh ◽  
M. Saeed Qureshi ◽  
...  
Keyword(s):  
Germinal Center ◽  
T Follicular Helper Cells ◽  
Indirect Pathway ◽  
Helper Cells ◽  
Follicular Helper
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