scholarly journals Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations

2020 ◽  
Vol 479 ◽  
pp. 112746 ◽  
Author(s):  
Colin Havenar-Daughton ◽  
Isabel G. Newton ◽  
Somaye Y. Zare ◽  
Samantha M. Reiss ◽  
Brittany Schwan ◽  
...  
Keyword(s):  
Lymph Node ◽  
B Cells ◽  
Germinal Center ◽  
T Follicular Helper Cells ◽  
Fine Needle ◽  
Helper Cells ◽  
Follicular Helper ◽  
Human Lymph Node ◽  
Normal Human ◽  
Germinal Center B Cells

scholarly journals Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Blood ◽  
2014 ◽  
Vol 123 (25) ◽  
pp. 3988-3998 ◽  
Author(s):  
Ryan Flynn ◽  
Jing Du ◽  
Rachelle G. Veenstra ◽  
Dawn K. Reichenbach ◽  
Angela Panoskaltsis-Mortari ◽  
...  
Keyword(s):  
B Cells ◽  
Murine Model ◽  
Germinal Center ◽  
Bronchiolitis Obliterans ◽  
T Follicular Helper Cells ◽  
Novel Therapeutics ◽  
Helper Cells ◽  
Follicular Helper ◽  
Key Points ◽  
Germinal Center B Cells

Key Points T follicular helper cells and germinal center B cells are increased and strongly correlate with the development of cGVHD in a murine model. Blocking mAbs for IL-21, ICOS, and CD40L are potential novel therapeutics for cGVHD.

scholarly journals Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations

2019 ◽  
Author(s):  
Colin Havenar-Daughton ◽  
Isabel G. Newton ◽  
Somaye Y Zare ◽  
Samantha M. Reiss ◽  
Min Ji Suh ◽  
...  
Keyword(s):  
Lymph Node ◽  
B Cells ◽  
Lymph Nodes ◽  
Germinal Center ◽  
Human Subjects ◽  
Germinal Centers ◽  
Healthy Human ◽  
Fine Needle ◽  
Follicular Helper ◽  
Human Lymph Node

ABSTRACTGerminal centers (GC) are critically important for the maturation of the antibody response and the generation of memory B cells, which are the basis for long-term protection from pathogens. Germinal centers only occur in lymphoid tissue, such as lymph nodes, and are not present in blood. Therefore, cells of the germinal center, including GC B cells and GC T follicular helper (TFH) cells, are not well-studied in humans under normal healthy conditions, due to the limited availability of healthy lymph node samples. We used a minimally invasive, routine clinical procedure, lymph node fine needle aspirations (LN FNAs), to obtain lymph node cells from healthy human subjects to establish benchmarks of GC cells under noninflammatory conditions. This study of 50 lymph nodes demonstrates that human LN FNAs are a safe and feasible technique for immunological research, and defines benchmarks for human GC biology. The findings indicate that assessment of the GC response via LN FNAs will have application to the study of human vaccination, allergy, and autoimmune disease.

scholarly journals Ibrutinib-Mediated Inhibition of cGVHD Pathogenic Pre-Germinal Center B-Cells and Follicular Helper Cells While Preserving Immune Memory and Th1 T-Cells

2018 ◽  
Vol 24 (3) ◽  
pp. S20-S21 ◽  
Author(s):  
Bita Sahaf ◽  
Dmitry Tebaykin ◽  
Melissa Hopper ◽  
Patricia Cheung ◽  
Fabiola Bittencourt ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Germinal Center ◽  
Immune Memory ◽  
Helper Cells ◽  
Follicular Helper ◽  
Germinal Center B Cells

scholarly journals Bhlhe40: Gatekeeper of the GC

2021 ◽  
Vol 219 (2) ◽  
Author(s):  
Stephen L. Nutt ◽  
Julie Tellier
Keyword(s):  
B Cells ◽  
Germinal Center ◽  
T Follicular Helper Cells ◽  
High Affinity ◽  
Helper Cells ◽  
Follicular Helper

The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211406) report that Bhlhe40 restrains GC output through distinct regulatory roles in both arms of the response.

SS1-7 IL-27 supports germinal center function through combined effects on T follicular helper cells and B cells

Cytokine ◽  
2010 ◽  
Vol 52 (1-2) ◽  
pp. 12
Author(s):  
Marcel Batten ◽  
Nandhini Ramamoorthi ◽  
Noelyn Kljavin ◽  
Nico Ghilardi
Keyword(s):  
B Cells ◽  
Germinal Center ◽  
Combined Effects ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper

scholarly journals The Role of CD4+ T Follicular Helper Cells in HIV Infection: From the Germinal Center to the Periphery

2017 ◽  
Vol 8 ◽  
Author(s):  
John Patrick Thornhill ◽  
Sarah Fidler ◽  
Paul Klenerman ◽  
John Frater ◽  
Chansavath Phetsouphanh
Keyword(s):  
Hiv Infection ◽  
Germinal Center ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper
Sign in / Sign up

Export Citation Format

Share Document