scholarly journals INFECTIOUS CATARRH OF MICE

1937 ◽  
Vol 65 (6) ◽  
pp. 851-860 ◽  
Author(s):  
John B. Nelson
Keyword(s):  
Direct Contact ◽  
Primary Cultures ◽  
Tissue Cultures ◽  
Pure Cultures ◽  
Primary Tissue ◽  
Close Parallel ◽  
Experimental Disease

Evidence is presented that the etiology of infectious murine catarrh is specifically referable to the coccobacilliform bodies. The disease was regularly produced in normal mice by the nasal instillation of primary tissue cultures. In the presence of the X bacillus, transfers of primary cultures were usually uninfective. Pure cultures, however, retained their pathogenicity through as many as 12 transfers. The onset and progress of the experimental disease were somewhat retarded in comparison with the natural disease, but in general there was a close parallel. Mice injected with cultures did, however, show a significant decrease in the incidence of rhinitis. Transmission by direct contact was demonstrated in the presence of a rhinitis but not in its absence.

scholarly journals RECIPROCAL TRANSMISSION TESTS WITH INFECTIOUS CATARRH OF CHICKENS, MICE, AND RATS

1942 ◽  
Vol 76 (3) ◽  
pp. 253-262 ◽  
Author(s):  
John B. Nelson
Keyword(s):  
Direct Contact ◽  
Tissue Cultures ◽  
Foot Pad ◽  
Slow Onset

Infectious catarrh of chickens (fowl coryza of slow onset) was not transmissible to mice or rats by nasal instillation of the specific coccobacilliform bodies. Exudates were also inactive in both rodents on foot pad injection. The infectious catarrhs of the mouse and the rat were reciprocally transmissible by the nasal injection of exudates or tissue cultures of the respective coccobacilliform bodies and by direct contact. Exudates and cultures also produced an arthritic reaction in both hosts on foot pad injection. The coccobacilliform bodies of mouse catarrh were innocuous in chickens on nasal instillation, whereas those of rat catarrh were established locally but were maintained for only two passages. In the opposite host each of the two rodent forms of infectious catarrh reproduced the typical features of the naturally acquired disease, a highly fatal pneumonia being characteristic of the mouse but not of the rat.

scholarly journals STUDIES ON THE MECHANISM OF ACTION OF RILEY VIRUS

1965 ◽  
Vol 122 (5) ◽  
pp. 993-1002 ◽  
Author(s):  
R. Evans ◽  
M. H. Salaman
Keyword(s):  
Virus Infection ◽  
Mouse Embryo ◽  
Primary Cultures ◽  
Serial Passage ◽  
Tissue Cultures ◽  
Embryo Cultures ◽  
Primary Mouse ◽  
Mouse Macrophages ◽  
Embryo Liver ◽  
Successful Replication

A study was made of the replication of Riley virus in various tissue cultures. It was observed that Riley virus replicated in primary mouse embryo cultures for 8 to 12 days. As they aged primary cultures became less susceptible to Riley virus infection, and subcultured cells were not susceptible. Suspensions of virus, in the absence of cells, were inactivated at 36.5°C. Serial passage by transfer of supernatant fluids to fresh embryo cultures was not successful. Replication of the virus was more active in mouse embryo liver cultures than in the cultures of the embryo minus the livers. In cultures of mouse macrophages, the supernatants remained infective throughout the life of the cultures (21 days). The virus was passed 23 times through fresh macrophage cultures over a period of 80 days, during which the original inoculum (106.0ID50/ml) was theoretically diluted to 10–14. The possibility that the cells of the RES are involved in Riley virus replication is discussed.

Sequential degeneration of mycoplasma-like bodies in plant tissue cultures infected with aster yellows

1978 ◽  
Vol 56 (2) ◽  
pp. 133-140 ◽  
Author(s):  
G. G. Jacoli
Keyword(s):  
Electron Microscopy ◽  
Plant Tissue ◽  
Final Stage ◽  
Primary Cultures ◽  
Tissue Cultures ◽  
Phloem Tissue ◽  
Aster Yellows ◽  
Second Stage ◽  
Plant Tissue Cultures ◽  
Three Stages

In carrot explants infected with aster yellows, mycoplasma-like bodies (MLBs) were seen only in the phloem of the primary cultures. During subsequent transfers of the cultures, MLBs underwent gradual degeneration and disappeared within 80 days. Electron microscopy showed three stages of degeneration. In the first stage, which started after about 30 days in culture, MLBs changed from a round to a filamentous shape and became electron opaque. During the second stage, the MLB membrane ruptured, and numerous unusual structures were observed. In the final stage, the MLB particles disrupted and the cells plasmolysed. Differentiation occurred earlier in infected than in healthy cultures, and the new phloem tissue contained no MLBs.

Myofibrillogenesis in primary tissue cultures of adult human skeletal muscle: expression of desmin, titin, and nebulin

1994 ◽  
Vol 72 (2) ◽  
pp. 150-155 ◽  
Author(s):  
T. Behr ◽  
P. Fischer ◽  
W. Müller-Felber ◽  
M. Schmidt-Achert ◽  
D. Pongratz
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Tissue Cultures ◽  
Adult Human ◽  
Primary Tissue
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